Welcome guest, Sign in

Home


Andrew P. Makrigiannis

Education

Ph.D. in Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada, 1998   

Current position

Professor-Canada Research Chair, Tier II in Innate Pathogen Resistance, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada

Director of Graduate Studies, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada

Publications (since 2005)

  1. Tai, L. H., Zhang, J., Scott, K. J., Tanese de Souza, C., Alkayyal, A. A., Abhirami Ananth, A., Sahi, S., Adair, R. A., Bakur Mahmoud, A., Sad, S., Bell, J. C., Makrigiannis, A. P., Melcher, A. A. and Auer, R. (2013). Perioperative influenza vaccination reduces post-operative metastatic disease by reversing surgery-induced dysfunction in natural killer cells. Clin Cancer Res. In press.
  2. Rahim, M. M.*, Tai, L. H.*, Troke, A. D., Mahmoud, A. B., Abou-Samra, E., Roy, J. G., Mottashed, A., Ault, N., Corbeil, C., Goulet, M. L., Zein, H. S., Hamilton-Valensky, M., Krystal, G., Kerr, W. G., Toyama-Sorimachi, N. and Makrigiannis, A. P. (2013). Ly49Q positively regulates type I IFN production by plasmacytoid dendritic cells in an immunoreceptor tyrosine-based inhibitory motif-dependent manner. J Immunol 190(8): 3994-4004. *denotes equal contribution.
  3. Tai, L. H., de Souza, C. T., Belanger, S., Ly, L., Alkayyal, A. A., Zhang, J., Rintoul, J. L., Ananth, A. A., Lam, T., Breitbach, C. J., Falls, T. J., Kirn, D. H., Bell, J. C., Makrigiannis, A. P. and Auer, R. A. (2013). Preventing postoperative metastatic disease by inhibiting surgery-induced dysfunction in natural killer cells. Cancer Res 73(1): 97-107.
  4. Zhang, Q., Rahim, M. M., Allan, D. S., Tu, M. M., Belanger, S., Abou-Samra, E., Ma, J., Sekhon, H. S., Fairhead, T., Zein, H. S., Carlyle, J. R., Anderson, S. K. and Makrigiannis, A. P. (2012). Mouse Nkrp1-Clr gene cluster sequence and expression analyses reveal conservation of tissue-specific MHC-independent immunosurveillance. PLoS ONE 7(12): e50561.
  5. Belanger, S., Tu, M. M., Rahim, M. M., Mahmoud, A. B., Patel, R., Tai, L. H., Troke, A. D., Wilhelm, B. T., Landry, J. R., Zhu, Q., Tung, K. S., Raulet, D. H. and Makrigiannis, A. P. (2012). Impaired natural killer cell self-education and "missing-self" responses in Ly49-deficient mice. Blood 120(3): 592-602.
  6. Heyward, C. Y., Patel, R., Mace, E. M., Grier, J. T., Guan, H., Makrigiannis, A. P., Orange, J. S. and Ricciardi, R. P. (2012). Tumorigenic adenovirus 12 cells evade NK cell lysis by reducing the expression of NKG2D ligands. Immunol Lett 144(1-2): 16-23.
  7. Chen, P.*, Belanger, S.*, Aguilar, O. A., Zhang, Q., St-Laurent, A., Rahim, M. M., Makrigiannis, A. P.* and Carlyle, J. R.* (2011). Analysis of the mouse 129-strain Nkrp1-Clr gene cluster reveals conservation of genomic organization and functional receptor-ligand interactions despite significant allelic polymorphism. Immunogenetics 63(10): 627-640. . *denotes equal contribution.
  8. Patel, R., Belanger, S., Tai, L. H., Troke, A. D. and Makrigiannis, A. P. (2010). Effect of Ly49 haplotype variance on NK cell function and education. J Immunol 185(8): 4783-4792.
  9. Xie, X., Stadnisky, M. D., Coats, E. R., Ahmed Rahim, M. M., Lundgren, A., Xu, W., Makrigiannis, A. P. and Brown, M. G. (2010). MHC class I D(k) expression in hematopoietic and nonhematopoietic cells confers natural killer cell resistance to murine cytomegalovirus. Proc Natl Acad Sci U S A 107(19): 8754-8759.
  10. Hayashi, M., Nakashima, T., Kodama, T., Makrigiannis, A. P., Toyama-Sorimachi, N. and Takayanagi, H. (2010). Ly49Q, an ITIM-bearing NK receptor, positively regulates osteoclast differentiation. Biochem Biophys Res Commun 393(3): 432-438.
  11. Sasawatari, S., Yoshizaki, M., Taya, C., Tazawa, A., Furuyama-Tanaka, K., Yonekawa, H., Dohi, T., Makrigiannis, A. P., Sasazuki, T., Inaba, K. and Toyama-Sorimachi, N. (2010). The Ly49Q receptor plays a crucial role in neutrophil polarization and migration by regulating raft trafficking. Immunity 32(2): 200-213.
  12. Yoshizaki, M., Tazawa, A., Kasumi, E., Sasawatari, S., Itoh, K., Dohi, T., Sasazuki, T., Inaba, K., Makrigiannis, A. P. and Toyama-Sorimachi, N. (2009). Spatiotemporal regulation of intracellular trafficking of Toll-like receptor 9 by an inhibitory receptor, Ly49Q. Blood 114(8): 1518-1527.
  13. Makrigiannis, A. P. and Parham, P. (2008). The evolution of NK cell diversity. Semin Immunol 20(6): 309-310.
  14. Carlyle, J. R., Mesci, A., Fine, J. H., Chen, P., Belanger, S., Tai, L. H. and Makrigiannis, A. P. (2008). Evolution of the Ly49 and Nkrp1 recognition systems. Semin Immunol 20(6): 321-330.
  15. Tai, L. H., Goulet, M. L., Belanger, S., Toyama-Sorimachi, N., Fodil-Cornu, N., Vidal, S. M., Troke, A. D., McVicar, D. W. and Makrigiannis, A. P. (2008). Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC. J Exp Med 205(13): 3187-3199.
  16. Fodil-Cornu, N., Lee, S. H., Belanger, S., Makrigiannis, A. P., Biron, C. A., Buller, R. M. and Vidal, S. M. (2008). Ly49h-deficient C57BL/6 mice: a new mouse cytomegalovirus-susceptible model remains resistant to unrelated pathogens controlled by the NK gene complex. J Immunol 181(9): 6394-6405.
  17. Belanger, S., Tai, L. H., Anderson, S. K. and Makrigiannis, A. P. (2008). Ly49 cluster sequence analysis in a mouse model of diabetes: an expanded repertoire of activating receptors in the NOD genome. Genes Immun 9(6): 509-521.
  18. Colina, R., Costa-Mattioli, M., Dowling, R. J., Jaramillo, M., Tai, L. H., Breitbach, C. J., Martineau, Y., Larsson, O., Rong, L., Svitkin, Y. V., Makrigiannis, A. P., Bell, J. C. and Sonenberg, N. (2008). Translational control of the innate immune response through IRF-7. Nature 452(7185): 323-328.
  19. Tai, L. H., Goulet, M. L., Belanger, S., Troke, A. D., St-Laurent, A. G., Mesci, A., Toyama-Sorimachi, N., Carlyle, J. R. and Makrigiannis, A. P. (2007). Recognition of H-2K(b) by Ly49Q suggests a role for class Ia MHC regulation of plasmacytoid dendritic cell function. Mol Immunol 44(10): 2638-2646.
  20. Mesci, A., Ljutic, B., Makrigiannis, A. P. and Carlyle, J. R. (2006). NKR-P1 biology: from prototype to missing self. Immunol Res 35(1-2): 13-26.
  21. Carlyle, J. R., Mesci, A., Ljutic, B., Belanger, S., Tai, L. H., Rousselle, E., Troke, A. D., Proteau, M. F. and Makrigiannis, A. P. (2006). Molecular and genetic basis for strain-dependent NK1.1 alloreactivity of mouse NK cells. J Immunol 176(12): 7511-7524.
  22. Anderson, S. K., Dewar, K., Goulet, M. L., Leveque, G. and Makrigiannis, A. P. (2005). Complete elucidation of a minimal class I MHC natural killer cell receptor haplotype. Genes Immun 6(6): 481-492.
  23. Desrosiers, M. P., Kielczewska, A., Loredo-Osti, J. C., Adam, S. G., Makrigiannis, A. P., Lemieux, S., Pham, T., Lodoen, M. B., Morgan, K., Lanier, L. L. and Vidal, S. M. (2005). Epistasis between mouse Klra and major histocompatibility complex class I loci is associated with a new mechanism of natural killer cell-mediated innate resistance to cytomegalovirus infection. Nat Genet 37(6): 593-599.
  24. Makrigiannis, A. P., Patel, D., Goulet, M. L., Dewar, K. and Anderson, S. K. (2005). Direct sequence comparison of two divergent class I MHC natural killer cell receptor haplotypes. Genes Immun 6(2): 71-83.
Protocols by Andrew P. Makrigiannis
  1. Ex vivo Natural Killer Cell Cytotoxicity Assay
  2. Natural Killer Cell Transfer Assay