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Lee-Hwa Tai


Ph.D. in Molecular Immunology, Institut de recherche clinique Montreal, Mcgill University, Montreal, Quebec, Canada, 2010

Current position

Assistant professor, Department of Pediatrics, Division of Immunology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Canada


  1. Tai, L. H. and Auer, R. (2014). Attacking postoperative metastases usingperioperative oncolytic viruses and viral vaccines. Front Oncol 4: 217. (Review)
  2. Zhang, J.*, Tai, L. H.*, Ilkow, C. S., Alkayyal, A. A., Ananth, A. A., de Souza, C. T., Wang, J., Sahi, S., Ly, L., Lefebvre, C., Falls, T. J., Stephenson, K. B., Mahmoud, A. B., Makrigiannis, A. P., Lichty, B. D., Bell, J. C., Stojdl, D. F. and Auer, R. C. (2014). Maraba MG1 virus enhances natural killer cell function via conventional dendritic cells to reduce postoperative metastatic disease. Mol Ther 22(7): 1320-1332. *(Denotes equal contribution) (IF=6.825).
  3. Tai, L. H., Tanese de Souza, C., Sahi, S., Zhang, J., Alkayyal, A. A., Ananth, A. A. and Auer, R. A. (2014). A mouse tumor model of surgical stress to explore the mechanisms of postoperative immunosuppression and evaluate novel perioperative immunotherapies. J Vis Exp (85).
  4. Tai, L.-H., Zhang, J. and Auer, R. C. (2013). Preventing surgery-induced NK cell dysfunction and cancer metastases with influenza vaccination. Oncoimmunology 2(11). (Review)
  5. Tai, L. H., Zhang, J., Scott, K. J., de Souza, C. T., Alkayyal, A. A., Ananth, A. A., Sahi, S., Adair, R. A., Mahmoud, A. B., Sad, S., Bell, J. C., Makrigiannis, A. P., Melcher, A. A. and Auer, R. C. (2013). Perioperative influenza vaccination reduces postoperative metastatic disease by reversing surgery-induced dysfunction in natural killer cells. Clin Cancer Res 19(18): 5104-5115. (IF=8.193)
  6. Rahim, M. M.*, Tai, L. H.*, Troke, A. D., Mahmoud, A. B., Abou-Samra, E., Roy, J. G., Mottashed, A., Ault, N., Corbeil, C., Goulet, M. L., Zein, H. S., Hamilton-Valensky, M., Krystal, G., Kerr, W. G., Toyama-Sorimachi, N. and Makrigiannis, A. P. (2013). Ly49Q positively regulates type I IFN production by plasmacytoid dendritic cells in an immunoreceptor tyrosine-based inhibitory motif-dependent manner. J Immunol 190(8): 3994-4004. (*Denotes equal contribution)
  7. Tai, L. H., de Souza, C. T., Belanger, S., Ly, L., Alkayyal, A. A., Zhang, J., Rintoul, J. L., Ananth, A. A., Lam, T., Breitbach, C. J., Falls, T. J., Kirn, D. H., Bell, J. C., Makrigiannis, A. P. and Auer, R. A. (2013). Preventing postoperative metastatic disease by inhibiting surgery-induced dysfunction in natural killer cells. Cancer Res 73(1): 97-107.
  8. Seth, R., Tai, L. H., Falls, T., de Souza, C. T., Bell, J. C., Carrier, M., Atkins, H., Boushey, R. and Auer, R. A. (2013). Surgical stress promotes the development of cancer metastases by a coagulation-dependent mechanism involving natural killer cells in a murine model. Ann Surg 258(1): 158-168.
  9. Belanger, S., Tu, M. M., Rahim, M. M., Mahmoud, A. B., Patel, R., Tai, L. H., Troke, A. D., Wilhelm, B. T., Landry, J. R., Zhu, Q., Tung, K. S., Raulet, D. H. and Makrigiannis, A. P. (2012). Impaired natural killer cell self-education and "missing-self" responses in Ly49-deficient mice. Blood 120(3): 592-602.
  10. Rintoul, J. L., Lemay, C. G., Tai, L. H., Stanford, M. M., Falls, T. J., de Souza, C. T., Bridle, B. W., Daneshmand, M., Ohashi, P. S., Wan, Y., Lichty, B. D., Mercer, A. A., Auer, R. C., Atkins, H. L. and Bell, J. C. (2012). ORFV: a novel oncolytic and immune stimulating parapoxvirus therapeutic. Mol Ther 20(6): 1148-1157.
  11. Patel, R., Belanger, S., Tai, L. H., Troke, A. D. and Makrigiannis, A. P. (2010). Effect of Ly49 haplotype variance on NK cell function and education. J Immunol 185(8): 4783-4792.
  12. Tai, L. H., Goulet, M. L., Belanger, S., Toyama-Sorimachi, N., Fodil-Cornu, N., Vidal, S. M., Troke, A. D., McVicar, D. W. and Makrigiannis, A. P. (2008). Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC. J Exp Med 205(13): 3187-3199.
  13. Carlyle, J. R., Mesci, A., Fine, J. H., Chen, P., Belanger, S., Tai, L. H. and Makrigiannis, A. P. (2008). Evolution of the Ly49 and Nkrp1 recognition systems. Semin Immunol 20(6): 321-330.
  14. Belanger, S., Tai, L. H., Anderson, S. K. and Makrigiannis, A. P. (2008). Ly49 cluster sequence analysis in a mouse model of diabetes: an expanded repertoire of activating receptors in the NOD genome. Genes Immun 9(6): 509-521.
  15. Colina, R., Costa-Mattioli, M., Dowling, R. J., Jaramillo, M., Tai, L. H., Breitbach, C. J., Martineau, Y., Larsson, O., Rong, L., Svitkin, Y. V., Makrigiannis, A. P., Bell, J. C. and Sonenberg, N. (2008). Translational control of the innate immune response through IRF-7. Nature 452(7185): 323-328.
  16. Tai, L. H., Goulet, M. L., Belanger, S., Troke, A. D., St-Laurent, A. G., Mesci, A., Toyama-Sorimachi, N., Carlyle, J. R. and Makrigiannis, A. P. (2007). Recognition of H-2K(b) by Ly49Q suggests a role for class Ia MHC regulation of plasmacytoid dendritic cell function. Mol Immunol 44(10): 2638-2646.
  17. Carlyle, J. R., Mesci, A., Ljutic, B., Belanger, S., Tai, L. H., Rousselle, E., Troke, A. D., Proteau, M. F. and Makrigiannis, A. P. (2006). Molecular and genetic basis for strain-dependent NK1.1 alloreactivity of mouse NK cells. J Immunol 176(12): 7511-7524.
Protocols by Lee-Hwa Tai
  1. Ex vivo Natural Killer Cell Cytotoxicity Assay
  2. Natural Killer Cell Transfer Assay