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Fabiana Scornik

Education

Ph.D. in Biophysics, University of Buenos Aires, 1993

Current position

She is an assistant Professor at the University of Girona, Spain, focused on cardiac channelopathies and the role of ion channels on the autonomic regulation of the heart

Selected Publications

  1. Riuro, H., Beltran-Alvarez, P., Tarradas, A., Selga, E., Campuzano, O., Verges, M., Pagans, S., Iglesias, A., Brugada, J., Brugada, P., Vazquez, F. M., Perez, G. J., Scornik, F. S. and Brugada, R. (2013). A missense mutation in the sodium channel beta2 subunit reveals SCN2B as a new candidate gene for Brugada syndrome. Hum Mutat 34(7): 961-966.
  2. Scornik, F. S., Bucciero, R. S., Wu, Y., Selga, E., Bosch Calero, C., Brugada, R. and Perez, G. J. (2013). DiBAC(4)(3) hits a "sweet spot" for the activation of arterial large-conductance Ca(2)(+)-activated potassium channels independently of the beta(1)-subunit. Am J Physiol Heart Circ Physiol 304(11): H1471-1482.
  3. Perez, G. J., Desai, M., Anderson, S. and Scornik, F. S. (2013). Large-conductance calcium-activated potassium current modulates excitability in isolated canine intracardiac neurons. Am J Physiol Cell Physiol 304(3): C280-286.
  4. Selga, E., Perez-Serra, A., Moreno-Asso, A., Anderson, S., Thomas, K., Desai, M., Brugada, R., Perez, G. J. and Scornik, F. S. (2013). Molecular heterogeneity of large-conductance calcium-activated potassium channels in canine intracardiac ganglia. Channels (Austin) 7(4).
  5. Tarradas, A., Selga, E., Beltran-Alvarez, P., Perez-Serra, A., Riuro, H., Pico, F., Iglesias, A., Campuzano, O., Castro-Urda, V., Fernandez-Lozano, I., Perez, G. J., Scornik, F. S. and Brugada, R. (2013). A novel missense mutation, I890T, in the pore region of cardiac sodium channel causes Brugada syndrome. PLoS One 8(1): e53220.
  6. Scornik, F. S., Desai, M., Brugada, R., Guerchicoff, A., Pollevick, G. D., Antzelevitch, C. and Perez, G. J. (2006). Functional expression of "cardiac-type" Nav1.5 sodium channel in canine intracardiac ganglia. Heart Rhythm 3(7): 842-850.
  7. Parsons, R. L., Barstow, K. L. and Scornik, F. S. (2002). Spontaneous miniature hyperpolarizations affect threshold for action potential generation in mudpuppy cardiac neurons. J Neurophysiol 88(3): 1119-1127.
  8. Di Diego, J. M., Cordeiro, J. M., Goodrow, R. J., Fish, J. M., Zygmunt, A. C., Perez, G. J., Scornik, F. S. and Antzelevitch, C. (2002). Ionic and cellular basis for the predominance of the Brugada syndrome phenotype in males. Circulation 106(15): 2004-2011.
  9. Scornik, F. S., Merriam, L. A. and Parsons, R. L. (2001). Number of K(Ca) channels underlying spontaneous miniature outward currents (SMOCs) in mudpuppy cardiac neurons. J Neurophysiol 85(1): 54-60.
  10. Merriam, L. A., Scornik, F. S. and Parsons, R. L. (1999). Ca(2+)-induced Ca(2+) release activates spontaneous miniature outward currents (SMOCs) in parasympathetic cardiac neurons. J Neurophysiol 82(2): 540-550.
  11. Scornik, F. S., Codina, J., Birnbaumer, L. and Toro, L. (1993). Modulation of coronary smooth muscle KCa channels by Gs alpha independent of phosphorylation by protein kinase A. Am J Physiol 265(4 Pt 2): H1460-1465.
Protocols by Fabiana Scornik
  1. Cell Surface Protein Biotinylation and Analysis
  2. Sodium Current Measurements in HEK293 Cells