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Jean Gagnon


Ph.D. in Biochemistry, University of Toronto, Toronto, Canada, 1976

Current position

CNRS - Research Director (retired), Laboratoire Pathogenie et Vaccination Lentivirales (PAVAL Lab), Université Grenoble Alpes, Grenoble,  France

Publications (since 2006)

  1. Lopez, J., Bittame, A., Massera, C., Vasseur, V., Effantin, G., Valat, A., Buaillon, C., Allart, S., Fox, B. A., Rommereim, L. M., Bzik, D. J., Schoehn, G., Weissenhorn, W., Dubremetz, J. F., Gagnon, J., Mercier, C., Cesbron-Delauw, M. F. and Blanchard, N. (2015). Intravacuolar Membranes Regulate CD8 T Cell Recognition of Membrane-Bound Toxoplasma gondii Protective Antigen. Cell Rep 13(10): 2273-2286.
  2. Chebloune, Y., Moussa, M., Arrode-Bruses, G. and Gagnon, J. (2015). Cowpox Helped Against Smallpox; Will the Goat Lentivirus (Caprine Arthritis Encephalitis Virus) Help Against HIV-1? AIDS Res Hum Retroviruses 31(6): 577-578.
  3. Moussa, M., Arrode-Bruses, G., Manoylov, I., Malogolovkin, A., Mompelat, D., Ishimwe, H., Smaoune, A., Ouzrout, B., Gagnon, J. and Chebloune, Y. (2015). A novel non-integrative single-cycle chimeric HIV lentivector DNA vaccine. Vaccine 33(19): 2273-2282.
  4. Bittame, A., Effantin, G., Petre, G., Ruffiot, P., Travier, L., Schoehn, G., Weissenhorn, W., Cesbron-Delauw, M. F., Gagnon, J. and Mercier, C. (2015). Toxoplasma gondii: biochemical and biophysical characterization of recombinant soluble dense granule proteins GRA2 and GRA6. Biochem Biophys Res Commun 459(1): 107-112.
  5. Lemaire-Vieille, C., Bailly, Y., Erlich, P., Loeuillet, C., Brocard, J., Haeberle, A. M., Bombarde, G., Rak, C., Demais, V., Dumestre-Perard, C., Gagnon, J. and Cesbron, J. Y. (2013). Ataxia with cerebellar lesions in mice expressing chimeric PrP-Dpl protein. J Neurosci 33(4): 1391-1399.
  6. Loeuillet, C., Lemaire-Vieille, C., Naquet, P., Cesbron-Delauw, M. F., Gagnon, J. and Cesbron, J. Y. (2010). Prion replication in the hematopoietic compartment is not required for neuroinvasion in scrapie mouse model. PLoS One 5(10).
  7. Loeuillet, C., Boelle, P. Y., Lemaire-Vieille, C., Baldazza, M., Naquet, P., Chambon, P., Cesbron-Delauw, M. F., Valleron, A. J., Gagnon, J. and Cesbron, J. Y. (2010). Sex effect in mouse and human prion disease. J Infect Dis 202(4): 648-654.
  8. Erlich, P., Dumestre-Perard, C., Ling, W. L., Lemaire-Vieille, C., Schoehn, G., Arlaud, G. J., Thielens, N. M., Gagnon, J. and Cesbron, J. Y. (2010). Complement protein C1q forms a complex with cytotoxic prion protein oligomers. J Biol Chem 285(25): 19267-19276.
  9. Dumestre-Perard, C., Lamy, B., Aldebert, D., Lemaire-Vieille, C., Grillot, R., Brion, J. P., Gagnon, J. and Cesbron, J. Y. (2008). Aspergillus conidia activate the complement by the mannan-binding lectin C2 bypass mechanism. J Immunol 181(10): 7100-7105.
  10. Erlich, P., Cesbron, J. Y., Lemaire-Vieille, C., Curt, A., Andrieu, J. P., Schoehn, G., Jamin, M. and Gagnon, J. (2008). PrP N-terminal domain triggers PrP(Sc)-like aggregation of Dpl. Biochem Biophys Res Commun 365(3): 478-483.
  11. Dumestre-Perard, C., Osmundson, J., Lemaire-Vieille, C., Thielens, N., Grives, A., Favier, B., Csopaki, F., Jamin, M., Gagnon, J. and Cesbron, J. Y. (2007). Activation of classical pathway of complement cascade by soluble oligomers of prion. Cell Microbiol 9(12): 2870-2879.
  12. Sanchez, J. F., Lescar, J., Chazalet, V., Audfray, A., Gagnon, J., Alvarez, R., Breton, C., Imberty, A. and Mitchell, E. P. (2006). Biochemical and structural analysis of Helix pomatia agglutinin. A hexameric lectin with a novel fold. J Biol Chem 281(29): 20171-20180.
  13. Bernay, B., Baudy-Floc'h, M., Gagnon, J. and Henry, J. (2006). Ovarian jelly-peptides (OJPs), a new family of regulatory peptides identified in the cephalopod Sepia officinalis. Peptides 27(6): 1259-1268.
Protocols by Jean Gagnon
  1. Protein Flotation Assay to Isolate Lipids Rafts from Soft Tissue or Cells
  2. Lipid Extraction from HeLa Cells, Quantification of Lipids, Formation of Large Unilamellar Vesicles (LUVs) by Extrusion and in vitro Protein-lipid Binding Assays, Analysis of the Incubation Product by Transmission Electron Microscopy (TEM) and by Flotation across a Discontinuous Sucrose Gradient