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Iryna Leshchyns’ka


Ph.D. in Biochemistry, Shevchenko National University, Kiev, Ukraine, 2001

Current position

Research Fellow, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia


Scholarly book chapters

  1. Schachner M, Leshchyns’ka I, Sytnyk V. 2009. The neural cell adhesion molecule NCAM and its postsynaptic functions. In Encyclopedia of Neuroscience. Elsevier/Great Britain, Oxford.

Refereed journal articles

  1. Li, S., Leshchyns'ka, I., Chernyshova, Y., Schachner, M. and Sytnyk, V. (2013). The neural cell adhesion molecule (NCAM) associates with and signals through p21-activated kinase 1 (Pak1). J Neurosci 33(2): 790-803.
  2. Tian, N., Leshchyns'ka, I., Welch, J. H., Diakowski, W., Yang, H., Schachner, M. and Sytnyk, V. (2012). Lipid raft-dependent endocytosis of close homolog of adhesion molecule L1 (CHL1) promotes neuritogenesis. J Biol Chem 287(53): 44447-44463.
  3. Poplawski, G. H., Tranziska, A. K., Leshchyns'ka, I., Meier, I. D., Streichert, T., Sytnyk, V. and Schachner, M. (2012). L1CAM increases MAP2 expression via the MAPK pathway to promote neurite outgrowth. Mol Cell Neurosci 50(2): 169-178.
  4. Leshchyns'ka, I., Tanaka, M. M., Schachner, M. and Sytnyk, V. (2011). Immobilized pool of NCAM180 in the postsynaptic membrane is homeostatically replenished by the flux of NCAM180 from extrasynaptic regions. J Biol Chem 286(26): 23397-23406.
  5. Puchkov, D., Leshchyns'ka, I., Nikonenko, A. G., Schachner, M. and Sytnyk, V. (2011). NCAM/spectrin complex disassembly results in PSD perforation and postsynaptic endocytic zone formation. Cereb Cortex 21(10): 2217-2232.
  6. Chernyshova, Y., Leshchyns'ka, I., Hsu, S. C., Schachner, M. and Sytnyk, V. (2011). The neural cell adhesion molecule promotes FGFR-dependent phosphorylation and membrane targeting of the exocyst complex to induce exocytosis in growth cones. J Neurosci 31(10): 3522-3535.
  7. Westphal, D., Sytnyk, V., Schachner, M. and Leshchyns'ka, I. (2010). Clustering of the neural cell adhesion molecule (NCAM) at the neuronal cell surface induces caspase-8- and -3-dependent changes of the spectrin meshwork required for NCAM-mediated neurite outgrowth. J Biol Chem 285(53): 42046-42057.
  8. Andreyeva, A., Leshchyns'ka, I., Knepper, M., Betzel, C., Redecke, L., Sytnyk, V. and Schachner, M. (2010). CHL1 is a selective organizer of the presynaptic machinery chaperoning the SNARE complex. PLoS One 5(8): e12018.
  9. Devanathan, V., Jakovcevski, I., Santuccione, A., Li, S., Lee, H. J., Peles, E., Leshchyns'ka, I., Sytnyk, V. and Schachner, M. (2010). Cellular form of prion protein inhibits Reelin-mediated shedding of Caspr from the neuronal cell surface to potentiate Caspr-mediated inhibition of neurite outgrowth. J Neurosci 30(27): 9292-9305.
  10. Bodrikov, V., Sytnyk, V., Leshchyns'ka, I., den Hertog, J. and Schachner, M. (2008). NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth. J Cell Biol 182(6): 1185-1200.
  11. Jakovcevski, I., Wu, J., Karl, N., Leshchyns'ka, I., Sytnyk, V., Chen, J., Irintchev, A. and Schachner, M. (2007). Glial scar expression of CHL1, the close homolog of the adhesion molecule L1, limits recovery after spinal cord injury. J Neurosci 27(27): 7222-7233.
  12. Leshchyns'ka, I., Sytnyk, V., Richter, M., Andreyeva, A., Puchkov, D. and Schachner, M. (2006). The adhesion molecule CHL1 regulates uncoating of clathrin-coated synaptic vesicles. Neuron 52(6): 1011-1025.
  13. Sytnyk, V., Leshchyns'ka, I., Nikonenko, A. G. and Schachner, M. (2006). NCAM promotes assembly and activity-dependent remodeling of the postsynaptic signaling complex. J Cell Biol 174(7): 1071-1085.
  14. Santuccione, A., Sytnyk, V., Leshchyns'ka, I. and Schachner, M. (2005). Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth. J Cell Biol 169(2): 341-354.
  15. Bodrikov, V., Leshchyns'ka, I., Sytnyk, V., Overvoorde, J., den Hertog, J. and Schachner, M. (2005). RPTPalpha is essential for NCAM-mediated p59fyn activation and neurite elongation. J Cell Biol 168(1): 127-139.
  16. Sytnyk, V., Leshchyns'ka, I., Dityatev, A. and Schachner, M. (2004). Trans-Golgi network delivery of synaptic proteins in synaptogenesis. J Cell Sci 117(Pt 3): 381-388.
  17. Leshchyns'ka, I., Sytnyk, V., Morrow, J. S. and Schachner, M. (2003). Neural cell adhesion molecule (NCAM) association with PKCbeta2 via betaI spectrin is implicated in NCAM-mediated neurite outgrowth. J Cell Biol 161(3): 625-639.
  18. Sytnyk, V., Leshchyns'ka, I., Delling, M., Dityateva, G., Dityatev, A. and Schachner, M. (2002). Neural cell adhesion molecule promotes accumulation of TGN organelles at sites of neuron-to-neuron contacts. J Cell Biol 159(4): 649-661.
  19. Ulrich, C., Prior, H., Duka, T., Leshchins'ka, I., Valenti, P., Gunturkun, O. and Lipp, H. P. (1999). Left-hemispheric superiority for visuospatial orientation in homing pigeons. Behav Brain Res 104(1-2): 169-178.
Protocols by Iryna Leshchyns’ka
  1. Isolation of Growth Cones from Mouse Brain