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Manuel E. Lopez


Ph.D. in Developmental Biology, Stanford University, 2011

Current position

Industry Postdoc, NGM Biopharmaceuticals, South San Francisco, CA (2013-current)
Background: Neurodegenerative and metabolic disease; neural bases of behavior; lysosome/endosome trafficking and lipid cell biology


  1. Lopez, M. E. and Scott, M. P. (2013). Genetic dissection of a cell-autonomous neurodegenerative disorder: lessons learned from mouse models of Niemann-Pick disease type C. Dis Model Mech 6(5): 1089-1100.
  2. Lopez, M. E., Klein, A. D. and Scott, M. P. (2012). Complement is dispensable for neurodegeneration in Niemann-Pick disease type C. J Neuroinflammation 9: 216.
  3. Lopez, M. E., Klein, A. D., Hong, J., Dimbil, U. J. and Scott, M. P. (2012). Neuronal and epithelial cell rescue resolves chronic systemic inflammation in the lipid storage disorder Niemann-Pick C. Hum Mol Genet 21(13): 2946-2960.
    Cover of Human Molecular Genetics 2012, 21(13)
  4. Lopez, M. E., Klein, A. D., Dimbil, U. J. and Scott, M. P. (2011). Anatomically defined neuron-based rescue of neurodegenerative Niemann-Pick type C disorder. J Neurosci 31(12): 4367-4378.
    Featured article in This Week In the Journal ( TWIJ), Neurobiology of Disease, The Journal of Neuroscience, 31(12):i-i
  5. Voronina, E., Lopez, M., Juliano, C. E., Gustafson, E., Song, J. L., Extavour, C., George, S., Oliveri, P., McClay, D. and Wessel, G. (2008). Vasa protein expression is restricted to the small micromeres of the sea urchin, but is inducible in other lineages early in development. Dev Biol 314(2): 276-286.
Protocols by Manuel E. Lopez
  1. A Quick, No Frills Approach to Mouse Genotyping
  2. Combined in situ Hybridization/Immunohistochemistry (ISH/IH) on Free-floating Vibratome Tissue Sections