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Peng Jin


Ph.D. in Mol. and Dev. Biology, University of Cincinnati, 1999

Current position

Associate Professor of Human Genetics, Department of Human Genetics, Emory University


  1. Song, C. X., Szulwach, K. E., Fu, Y., Dai, Q., Yi, C., Li, X., Li, Y., Chen, C. H., Zhang, W., Jian, X., Wang, J., Zhang, L., Looney, T. J., Zhang, B., Godley, L. A., Hicks, L. M., Lahn, B. T., Jin, P.* and He, C.* (2011). Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol 29(1): 68-72. (*Co-Corresponding authors)
  2. Guo, W., Allan, A. M., Zong, R., Zhang, L., Johnson, E. B., Schaller, E. G., Murthy, A. C., Goggin, S. L., Eisch, A. J., Oostra, B. A., Nelson, D. L., Jin, P. and Zhao, X. (2011). Ablation of Fmrp in adult neural stem cells disrupts hippocampus-dependent learning. Nat Med 17(5): 559-565.
  3. Qurashi, A., Li, W., Zhou, J. Y., Peng, J. and Jin, P. (2011). Nuclear accumulation of stress response mRNAs contributes to the neurodegeneration caused by Fragile X premutation rCGG repeats. PLoS Genet 7(6): e1002102.
  4. Guo, W., Zhang, L., Christopher, D. M., Teng, Z. Q., Fausett, S. R., Liu, C., George, O. L., Klingensmith, J., Jin, P. and Zhao, X. (2011). RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression. Neuron 70(5): 924-938.
  5. Szulwach, K. E., Li, X., Li, Y., Song, C. X., Han, J. W., Kim, S., Namburi, S., Hermetz, K., Kim, J. J., Rudd, M. K., Yoon, Y. S., Ren, B., He, C. and Jin, P. (2011). Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells. PLoS Genet 7(6): e1002154.
  6. Szulwach, K. E., Li, X., Li, Y., Song, C. X., Wu, H., Dai, Q., Irier, H., Upadhyay, A. K., Gearing, M., Levey, A. I., Vasanthakumar, A., Godley, L. A., Chang, Q., Cheng, X., He, C. and Jin, P. (2011). 5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nat Neurosci 14(12): 1607-1616.
  7. Szulwach, K. E., Li, X., Smrt, R. D., Li, Y., Luo, Y., Lin, L., Santistevan, N. J., Li, W., Zhao, X. and Jin, P. (2010). Cross talk between microRNA and epigenetic regulation in adult neurogenesis. J Cell Biol 189(1): 127-141.
  8. Luo, Y., Shan, G., Guo, W., Smrt, R. D., Johnson, E. B., Li, X., Pfeiffer, R. L., Szulwach, K. E., Duan, R., Barkho, B. Z., Li, W., Liu, C., Jin, P.* and Zhao, X.* (2010). Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. PLoS Genet 6(4): e1000898. (*Co-Corresponding authors)
  9. Liu, C., Teng, Z. Q., Santistevan, N. J., Szulwach, K. E., Guo, W., Jin, P. and Zhao, X. (2010). Epigenetic regulation of miR-184 by MBD1 governs neural stem cell proliferation and differentiation. Cell Stem Cell 6(5): 433-444.
  10. Smrt, R. D., Szulwach, K. E., Pfeiffer, R. L., Li, X., Guo, W., Pathania, M., Teng, Z. Q., Luo, Y., Peng, J., Bordey, A., Jin, P.* and Zhao, X.* (2010). MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1. Stem Cells 28(6): 1060-1070. (*Co-Corresponding authors)
  11. Li, X. and Jin, P. (2010). Roles of small regulatory RNAs in determining neuronal identity. Nat Rev Neurosci 11(5): 329-338.
  12. Li, Y., He, C. and Jin, P. (2010). Emergence of chemical biology approaches to the RNAi/miRNA pathway. Chem Biol 17(6): 584-589.
  13. Yang, Y., Xu, S., Xia, L., Wang, J., Wen, S., Jin, P.* and Chen, D.* (2009). The bantam microRNA is associated with drosophila fragile X mental retardation protein and regulates the fate of germline stem cells. PLoS Genet 5(4): e1000444. (*Co-Corresponding authors)
  14. Chang, S., Bray, S. M., Li, Z., Zarnescu, D. C., He, C., Jin, P. and Warren, S. T. (2008). Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila. Nat Chem Biol 4(4): 256-263.
  15. Allan, A. M., Liang, X., Luo, Y., Pak, C., Li, X., Szulwach, K. E., Chen, D., Jin, P. and Zhao, X. (2008). The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficits. Human molecular genetics 17(13): 2047-2057.
  16. Shan, G., Li, Y., Zhang, J., Li, W., Szulwach, K. E., Duan, R., Faghihi, M. A., Khalil, A. M., Lu, L., Paroo, Z., Chan, A. W., Shi, Z., Liu, Q., Wahlestedt, C., He, C. and Jin, P. (2008). A small molecule enhances RNA interference and promotes microRNA processing. Nat Biotechnol 26(8): 933-940.
  17. Jin, P. *, Duan, R., Qurashi, A., Qin, Y., Tian, D., Rosser, T. C., Liu, H., Feng, Y. and Warren, S. T. (2007). Pur alpha binds to rCGG repeats and modulates repeat-mediated neurodegeneration in a Drosophila model of fragile X tremor/ataxia syndrome. Neuron 55(4): 556-564. (*Co-Corresponding authors)
  18. Zarnescu, D. C., Jin, P., Betschinger, J., Nakamoto, M., Wang, Y., Dockendorff, T. C., Feng, Y., Jongens, T. A., Sisson, J. C., Knoblich, J. A., Warren, S. T. and Moses, K. (2005). Fragile X protein functions with lgl and the par complex in flies and mice. Dev Cell 8(1): 43-52.
  19. Nakamoto, M., Jin, P., O'Donnell, W. T. and Warren, S. T. (2005). Physiological identification of human transcripts translationally regulated by a specific microRNA. Hum Mol Genet 14(24): 3813-3821.
  20. Jin, P., Zarnescu, D. C., Ceman, S., Nakamoto, M., Mowrey, J., Jongens, T. A., Nelson, D. L., Moses, K. and Warren, S. T. (2004). Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway. Nat Neurosci 7(2): 113-117.
  21. Jin, P., Alisch, R. S. and Warren, S. T. (2004). RNA and microRNAs in fragile X mental retardation. Nat Cell Biol 6(11): 1048-1053.
  22. Jin, P., Zarnescu, D. C., Zhang, F., Pearson, C. E., Lucchesi, J. C., Moses, K. and Warren, S. T. (2003). RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila. Neuron 39(5): 739-747.
  23. Brown, V.*, Jin, P.*, Ceman, S., Darnell, J. C., O'Donnell, W. T., Tenenbaum, S. A., Jin, X., Feng, Y., Wilkinson, K. D., Keene, J. D., Darnell, R. B. and Warren, S. T. (2001). Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. Cell 107(4): 477-487. (*equal contribution)
  24. Darnell, J. C., Jensen, K. B., Jin, P., Brown, V., Warren, S. T. and Darnell, R. B. (2001). Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function. Cell 107(4): 489-499.
Protocols by Peng Jin
  1. 5-Hydroxymethylcytosine (5-hmC) Specific Enrichment