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Jianyang  Wang

Jianyang Wang


Ph.D., Université Blaise Pascal, Clermont-Ferrand, France, 2007

Current position

Postdoctoral Fellow, Departments of Biological Chemistry / Cell Biology, Johns Hopkins School of Medicine (with Dr. Paul T. Englund and Dr. Robert E. Jensen)

Publications (since 2005)

  1. Wang, J., Englund, P. T. and Jensen, R. E. (2012). TbPIF8, a Trypanosoma brucei protein related to the yeast Pif1 helicase, is essential for cell viability and mitochondrial genome maintenance. Mol Microbiol 83(3): 471-485.    
  2. Roy Chowdhury, A., Bakshi, R., Wang, J., Yildirir, G., Liu, B., Pappas-Brown, V., Tolun, G., Griffith, J. D., Shapiro, T. A., Jensen, R. E. and Englund, P. T. (2010). The killing of African trypanosomes by ethidium bromide. PLoS Pathog 6(12): e1001226.    
  3. Liu, B., Yildirir, G., Wang, J., Tolun, G., Griffith, J. D. and Englund, P. T. (2010). TbPIF1, a Trypanosoma brucei mitochondrial DNA helicase, is essential for kinetoplast minicircle replication. J Biol Chem 285(10): 7056-7066.    
  4. Liu, B., Wang, J., Yildirir, G. and Englund, P. T. (2009). TbPIF5 is a Trypanosoma brucei mitochondrial DNA helicase involved in processing of minicircle Okazaki fragments. PLoS Pathog 5(9): e1000589.    
  5. Liu, B., Wang, J., Yaffe, N., Lindsay, M. E., Zhao, Z., Zick, A., Shlomai, J. and Englund, P. T. (2009). Trypanosomes have six mitochondrial DNA helicases with one controlling kinetoplast maxicircle replication. Mol Cell 35(4): 490-501.   
    Editorial Research Highlight at Nature Reviews Molecular Cell Biology (2009) Oct., Vol. 10: p654. DNA replication: Unwinding maxicircle DNA (Rachel David)
    Commentary Previews at Mol. Cell. 2009 Aug 28;35(4):398-400.         
    Unraveling the secrets of regulating mitochondrial DNA replication. (Klingbeil MM, Shapiro TA)
  6. Zhang, Y., Zhang, X., Xia, H., Xue, Y., Wang, J., Tian, B., Wei, Z. and Lu, C. (2008). Quantitative analysis of cytoplasmic actin gene promoter and nuclear polyhedrosis virus immediate-early promoter activities in various tissues of silkworm Bombyx mori using recombinant Autographa californica nuclear polyhedrosis virus as vector. Acta Biochim Biophys Sin (Shanghai) 40(6): 533-538.
  7. Zhang, Y., Tian, B., Xia, H., Guo, T., Wang, J., Wang, S., Wei, Z. and Lu, C. (2008). Spread of recombinant Autographa californica nucleopolyhedrovirus in various tissues of silkworm Bombyx mori determined by real-time PCR. Anal Biochem 373(1): 147-153.
  8. Wang, J. Y., Chambon, C., Lu, C. D., Huang, K. W., Vivares, C. P. and Texier, C. (2007). A proteomic-based approach for the characterization of some major structural proteins involved in host-parasite relationships from the silkworm parasite Nosema bombycis (Microsporidia). Proteomics 7(9): 1461-1472.  (Cover Figures)
  9. Wang J, Prensier G, Wang L, Vivarès CP, and Texier C. (2007) Identification of major structural proteins of the Microsporidia Nosema bombycis, a parasite of the silkworm Bombyx mori, and interactions with its host. Abstract in J. Eukaryot. Microbiol., 54(2), 26S: 68A.
  10. Guo, T. Q., Wang, J. Y.*, Wang, S. P., Guo, X. Y., Huang, K. W., Huang, J. T. and Lu, C. D. (2005). Loss of posterior silk gland transcription specificity of fibroin light chain promoter due to absence of 41 bp sequence containing possible inhibitor binding sites. Acta Biochim Biophys Sin (Shanghai) 37(12): 819-825. * Co-first authors    
  11. Guo, T. Q., Wang, J. Y., Guo, X. Y., Wang, S. P. and Lu, C. D. (2005). Transient in vivo gene delivery to the silkworm Bombyx mori by EGT-null recombinant AcNPV using EGFP as a reporter. Arch Virol 150(1): 93-105.    
  12. Guo, X. Y., Guo, T. Q., Wang, S. P., Wang, J. Y. and Lu, C. D. (2005). Silk gland specific secretory expression of egfp gene in silkworm Bombyx mori with rAcMNPV system. Arch Virol 150(6): 1151-1160. 
Protocols by Jianyang Wang
  1. EdU labeling of Trypanosome Cells and Their Kinetoplast DNA (kDNA)