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Maureen Wirschell

Education

Ph.D. in Cell Biology, University of Massachusetts Medical School, Worcester, MA, 2004

Current position

Assistant Professor, Dept. of Biochemistry, University of Mississippi Medical Center, Jackson, MS

Publications

Note: publications with “Blomberg, M" and "Blomberg-Wirschell, M” use the author's maiden name and former hyphenated last name respectively.

  1. Wirschell, M., Olbrich, H., Werner, C., Tritschler, D., Bower, R., Sale, W. S., Loges, N. T., Pennekamp, P., Lindberg, S., Stenram, U., Carlen, B., Horak, E., Kohler, G., Nurnberg, P., Nurnberg, G., Porter, M. E. and Omran, H. (2013). The nexin-dynein regulatory complex subunit DRC1 is essential for motile cilia function in algae and humans. Nat Genet 45(3): 262-268.
  2. Yamamoto, R., Song, K., Yanagisawa, H. A., Fox, L., Yagi, T., Wirschell, M., Hirono, M., Kamiya, R., Nicastro, D. and Sale, W. S. (2013). The MIA complex is a conserved and novel dynein regulator essential for normal ciliary motility. J Cell Biol 201(2): 263-278.
  3. Wirschell, M., Yamamoto, R., Alford, L., Gokhale, A., Gaillard, A. and Sale, W. S. (2011). Regulation of ciliary motility: conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme. Arch Biochem Biophys 510(2): 93-100.
  4. Alford, L., Wirschell, M., Yamamoto, R. and Sale, W. S. (2011). Control of axonemal inner dynein arms. Dyneins: Structure, Biology and Disease: 313.
  5. Elam, C. A., Wirschell, M., Yamamoto, R., Fox, L. A., York, K., Kamiya, R., Dutcher, S. K. and Sale, W. S. (2011). An axonemal PP2A B-subunit is required for PP2A localization and flagellar motility. Cytoskeleton (Hoboken) 68(7): 363-372.
  6. Wirschell, M., and Dutcher, SK. (2011). Algal Flagella. Encyclopedia of Life Sciences. www.els.net.
  7. Hom, E. F., Witman, G. B., Harris, E. H., Dutcher, S. K., Kamiya, R., Mitchell, D. R., Pazour, G. J., Porter, M. E., Sale, W. S., Wirschell, M., Yagi, T. and King, S. M. (2011). A unified taxonomy for ciliary dyneins. Cytoskeleton (Hoboken) 68(10): 555-565.
  8. Gokhale A., Wirschell M., Sale WS and Mitchell DM. 2010. Regulation of ciliary and flagellar dyneins. In The Dynein Handbook, edited by Linda Amos. Book Chapter in press.
  9. Wirschell M, Nicastro D., Porter ME., and Sale WS. (2009). Structural basis for regulation of flagellar motility: organization of the dynein regulatory complex, inter-dynein linkers and a network of axonemal kinases and phosphatases. The Chlamydomonas Sourcebook. G.B. Witman, editor.
  10. Ikeda, K., Yamamoto, R., Wirschell, M., Yagi, T., Bower, R., Porter, M. E., Sale, W. S. and Kamiya, R. (2009). A novel ankyrin-repeat protein interacts with the regulatory proteins of inner arm dynein f (I1) of Chlamydomonas reinhardtii. Cell Motil Cytoskeleton 66(8): 448-456.
  11. Wirschell, M., Yang, C., Yang, P., Fox, L., Yanagisawa, H. A., Kamiya, R., Witman, G. B., Porter, M. E. and Sale, W. S. (2009). IC97 is a novel intermediate chain of I1 dynein that interacts with tubulin and regulates interdoublet sliding. Mol Biol Cell 20(13): 3044-3054.
  12. Bower, R., VanderWaal, K., O'Toole, E., Fox, L., Perrone, C., Mueller, J., Wirschell, M., Kamiya, R., Sale, W. S. and Porter, M. E. (2009). IC138 defines a subdomain at the base of the I1 dynein that regulates microtubule sliding and flagellar motility. Mol Biol Cell 20(13): 3055-3063.
  13. Elam, C. A., Sale, W. S. and Wirschell, M. (2009). The regulation of dynein-driven microtubule sliding in Chlamydomonas flagella by axonemal kinases and phosphatases. Methods Cell Biol 92: 133-151.
  14. Yang, P., Yang, C., Wirschell, M. and Davis, S. (2009). Novel LC8 mutations have disparate effects on the assembly and stability of flagellar complexes. J Biol Chem 284(45): 31412-31421.
  15. Gokhale, A., Wirschell, M. and Sale, W. S. (2009). Regulation of dynein-driven microtubule sliding by the axonemal protein kinase CK1 in Chlamydomonas flagella. J Cell Biol 186(6): 817-824.
  16. Wirschell, M., Zhao, F., Yang, C., Yang, P., Diener, D., Gaillard, A., Rosenbaum, J. L. and Sale, W. S. (2008). Building a radial spoke: flagellar radial spoke protein 3 (RSP3) is a dimer. Cell Motil Cytoskeleton 65(3): 238-248.
  17. Wirschell, M., Hendrickson, T. and Sale, W. S. (2007). Keeping an eye on I1: I1 dynein as a model for flagellar dynein assembly and regulation. Cell Motil Cytoskeleton 64(8): 569-579.
  18. Wirschell, M., Pazour, G., Yoda, A., Hirono, M., Kamiya, R. and Witman, G. B. (2004). Oda5p, a novel axonemal protein required for assembly of the outer dynein arm and an associated adenylate kinase. Mol Biol Cell 15(6): 2729-2741.
  19. Gromley, A., Jurczyk, A., Sillibourne, J., Halilovic, E., Mogensen, M., Groisman, I., Blomberg, M. and Doxsey, S. (2003). A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase. J Cell Biol 161(3): 535-545.
  20. Blomberg, M., Rao, S., Reilly, J., Tiarks, C., Peters, S., Kittler, E. and Quesenberry, P. (1998). Repetitive bone marrow transplantation in nonmyeloablated recipients. Exp Hematol 26(4): 320-324.
  21. Blomberg-Wirschell, M. and Doxsey, S. J. (1998). Rapid isolation of centrosomes. Methods Enzymol 298: 228-238.
  22. Quesenberry, P. J., Ramshaw, H., Crittenden, R. B., Stewart, F. M., Rao, S., Peters, S., Becker, P., Lowry, P., Blomberg, M., Reilly, J. and et al. (1994). Engraftment of normal murine marrow into nonmyeloablated host mice. Blood Cells 20(2-3): 348-350
  23. Koevary, S. B. and Blomberg, M. (1992). Prevention of diabetes in BB/Wor rats by intrathymic islet injection. J Clin Invest 89(2): 512-516.
Protocols by Maureen Wirschell
  1. Generation of Polyclonal Specific Antibodies