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Ivan Zanoni

Education

Ph.D. in Immunology, University of Roma Tor Vergata, Rome, Italy

Current position

Staff Scientist, Boston Children’s Hospital, Boston, MA
Assistant Professor, University of Milano-Bicocca, Milan, Italy
My laboratory studies innate immune cell biology as a means of understanding the earliest events that initiate immunity to infection or drive the development of immune-mediated diseases. My research has focused primarily on the study of Pattern Recognition Receptor (PRR) signaling pathways. PRRs initiate all immune responses and activate a network of transcription factors that orchestrate the inflammatory response. The organizing principles that govern PRR signaling are largely unknown and their elucidation will likely answer several fundamental questions about the pathophysiological development of the inflammatory process.

Publications (selected)

  1. Di Gioia, M. and Zanoni, I. (2014). Toll-like receptor co-receptors as master regulators of the immune response. Mol Immunol. (Epub ahead of print)
  2. Zanoni, I. and Granucci, F. (2013). Role of CD14 in host protection against infections and in metabolism regulation. Front Cell Infect Microbiol 3: 32.
  3. Zanoni, I., Spreafico, R., Bodio, C., Di Gioia, M., Cigni, C., Broggi, A., Gorletta, T., Caccia, M., Chirico, G. and Sironi, L. (2013). IL-15 cis Presentation Is Required for Optimal NK Cell Activation in Lipopolysaccharide-Mediated Inflammatory Conditions. Cell Rep 4(6): 1235-1249.
  4. Zanoni, I., Ostuni, R., Barresi, S., Di Gioia, M., Broggi, A., Costa, B., Marzi, R. and Granucci, F. (2012). CD14 and NFAT mediate lipopolysaccharide-induced skin edema formation in mice. J Clin Invest 122(5): 1747-1757.
  5. Zanoni, I., Bodio, C., Broggi, A., Ostuni, R., Caccia, M., Collini, M., Venkatesh, A., Spreafico, R., Capuano, G. and Granucci, F. (2012). Similarities and differences of innate immune responses elicited by smooth and rough LPS. Immunol Lett 142(1-2): 41-47.
  6. Zanoni, I. and Granucci, F. (2012). Regulation and dysregulation of innate immunity by NFAT signaling downstream of pattern recognition receptors (PRRs). Eur J Immunol 42(8): 1924-1931.
  7.  Vitali, C., Mingozzi, F., Broggi, A., Barresi, S., Zolezzi, F., Bayry, J., Raimondi, G., Zanoni, I. and Granucci, F. (2012). Migratory, and not lymphoid-resident, dendritic cells maintain peripheral self-tolerance and prevent autoimmunity via induction of iTreg cells. Blood 120(6): 1237-1245.
  8. Zanoni, I., Ostuni, R., Marek, L. R., Barresi, S., Barbalat, R., Barton, G. M., Granucci, F. and Kagan, J. C. (2011). CD14 controls the LPS-induced endocytosis of Toll-like receptor 4. Cell 147(4): 868-880. 
  9. Zanoni, I., Ostuni, R., Capuano, G., Collini, M., Caccia, M., Ronchi, A. E., Rocchetti, M., Mingozzi, F., Foti, M., Chirico, G., Costa, B., Zaza, A., Ricciardi-Castagnoli, P. and Granucci, F. (2009). CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation. Nature 460(7252): 264-268.
  10. Zanoni, I., Foti, M., Ricciardi-Castagnoli, P. and Granucci, F. (2005). TLR-dependent activation stimuli associated with Th1 responses confer NK cell stimulatory capacity to mouse dendritic cells. J Immunol 175(1): 286-292.
Protocols by Ivan Zanoni
  1. Generation of Mouse Bone Marrow-Derived Dendritic Cells (BM-DCs)
  2. Generation of Mouse Bone Marrow-Derived Macrophages (BM-MFs)