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Michel Cayouette

Education

Ph.D. in Neurobiology, Université Laval, Québec, Canada, 1999

Current position

Associate Research Professor, Department of Medicine, Université de Montréal Montréal, QC, Canada (2011-to date)
Adjunct Professor, 1) Department of Anatomy and Cell Biology; and 2) Division of Experimental Medicine, McGill University, Montreal, QC, Canada (2005-to date)
Director, Cellular Neurobiology Research Unit, Institut de recherches cliniques de Montréal (IRCM) (2004-to date)

Publications

  1. Tarchini, B., Jolicoeur, C. and Cayouette, M. (2013). A Molecular Blueprint at the Apical Surface Establishes Planar Asymmetry in Cochlear Hair Cells. Developmental cell 27(1): 88-102.
  2. Cayouette, M.*, Mattar, P. and Harris, W. A.* (2013). Progenitor competence: genes switching places. Cell 152(1-2): 13-14.
    *Corresponding authors
  3. Alsiö, J., Tarchini, B., Cayouette, M. and Livesey, R. (2012). IIkaros promotes early-born neuronal fates in the cerebral cortex. Proc. Natl. Acad. Sci. (USA), 110(8): E716-25.
  4. Tarchini, B., Jolicoeur, C. and Cayouette, M. (2012). In vivo evidence for unbiased ikaros retinal lineages using an ikaros‐cre mouse line driving clonal recombination. Developmental Dynamics 241(12): 1973-1985.
  5. Kechad, A., Jolicoeur, C., Tufford, A., Mattar, P., Chow, R. W., Harris, W. A. and Cayouette, M. (2012). Numb is Required for the Production of Terminal Asymmetric Cell Divisions in the Developing Mouse Retina. The Journal of Neuroscience 32(48): 17197-17210.
  6. He, J., Zhang, G., Almeida, A. D., Cayouette, M., Simons, B. D. and Harris, W. A. (2012). How variable clones build an invariant retina. Neuron 75(5): 786-798.
    [Highlighted in a Preview: Neuron, 75(5): 739-741]
  7. Gomes, F. L., Zhang, G., Carbonell, F., Correa, J. A., Harris, W. A., Simons, B. D. and Cayouette, M. (2011). Reconstruction of rat retinal progenitor cell lineages in vitro reveals a surprising degree of stochasticity in cell fate decisions. Development 138(2): 227-235.
    [Highlighted in the “This Month” section of the journal. F1000 ranked “Must Read”]
  8. Cohen, F. L.*, Gomes, A. F.*, Roysam, B. and Cayouette, M. (2010). Computational prediction of retinal progenitor cell fates. Nature Methods 7(3):213-218. * Equal contributions
    [F1000 ranked “Must Read”]
  9. Ramamurthy, V. and Cayouette, M. (2009). Development and disease of the photoreceptor cilium. Clin Genet 76(2): 137-145.
  10. Elliott, J., Jolicoeur, C., Ramamurthy, V. and Cayouette, M. (2008). Ikaros confers early temporal competence to mouse retinal progenitor cells. Neuron 60(1): 26-39.
  11. Cayouette, M. (2007). Expanding neuronal layers by the local division of committed precursors. Neuron 56(4): 575-577.
  12. Elliott, J. and Cayouette, M. (2007). [The polarity protein Par-3 regulates myelination]. Med Sci (Paris) 23(3): 259-260.
  13. Chan, J. R., Jolicoeur, C., Yamauchi, J., Elliott, J., Fawcett, J. P., Ng, B. K. and Cayouette, M. (2006). The polarity protein Par-3 directly interacts with p75NTR to regulate myelination. Science 314(5800): 832-836.
    [News and Views in: Nat Neurosci. 2007;10(1):17-18. F1000 ranked “Must Read”]
  14. Elliott, J., Cayouette, M.* and Gravel, C. (2006). The CNTF/LIF signaling pathway regulates developmental programmed cell death and differentiation of rod precursor cells in the mouse retina in vivo. Dev Biol 300(2): 583-598.
    *Corresponding author
  15. Cayouette, M.*, Poggi, L. and Harris, W. A.* (2006). Lineage in the vertebrate retina. Trends Neurosci 29(10): 563-570.
    *Corresponding authors
  16. Zigman, M.*, Cayouette, M.*, Charalambous, C., Schleiffer, A., Hoeller, O., Dunican, D., McCudden, C. R., Firnberg, N., Barres, B. A., Siderovski, D. P. and Knoblich, J. A. (2005). Mammalian inscuteable regulates spindle orientation and cell fate in the developing retina. Neuron 48(4): 539-545.
    *Equal contribution
  17. Cayouette, M., Barres, B. A. and Raff, M. (2003). Importance of intrinsic mechanisms in cell fate decisions in the developing rat retina. Neuron 40(5): 897-904.
  18. Cayouette, M. and Raff, M. (2003). The orientation of cell division influences cell-fate choice in the developing mammalian retina. Development 130(11): 2329-2339.
  19. Das, T., Payer, B., Cayouette, M. and Harris, W. A. (2003). In vivo time-lapse imaging of cell divisions during neurogenesis in the developing zebrafish retina. Neuron 37(4): 597-609.
    [F1000 ranked “Exceptional”]
  20. Cayouette, M. and Raff, M. (2002). Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals. Nat Neurosci 5(12): 1265-1269.
  21. Cayouette, M., Whitmore, A. V., Jeffery, G. and Raff, M. (2001). Asymmetric segregation of Numb in retinal development and the influence of the pigmented epithelium. J Neurosci 21(15): 5643-5651.
  22. Cayouette, M., Smith, S. B., Becerra, S. P. and Gravel, C. (1999). Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Neurobiol Dis 6(6): 523-532.
  23. Cayouette, M., Behn, D., Sendtner, M., Lachapelle, P. and Gravel, C. (1998). Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse. J Neurosci 18(22): 9282-9293.
  24. Cayouette, M. and Gravel, C. (1997). Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse. Human gene therapy 8(4): 423-430.
  25. Cayouette, M. and Gravel, C. (1996). Adenovirus-mediated gene transfer to retinal ganglion cells. Invest Ophthalmol Vis Sci 37(10): 2022-2028

Book chapters

  1. Becerra, S. P., Alberdi, E., Martinez, A., Montuenga, L., Cayouette, M. and Gravel, C. (1999). Pigment Epithelium-Derived Factor (PEDF) in the Retina: Protective Effect Against Photoreceptor Cell Degeneration. In Retinal Degenerative Diseases and Experimental Therapy, Hollyfield et al. editors, Plenum Publishers, New York, pp 519-526.
  2. Gomes, F. L. A. F. and Cayouette, M. (2009). Cell type specification in the retina. In Encyclopedia of Neuroscience. Editor-in-Chief: Larry R. Squire, Elsevier Ltd., Pages: 203-209. ISBN: 978-0-08-045046-9.
  3. Gomes, F. L. A. F. and Cayouette, M. (2009). Retinal development: Cell type specification. In Developmental Neurobiology. Edited by Greg Lemke, Oxford: Academic Press.
  4. Gomes, F.L.A. F. and Cayouette, M. (2010). Retinal cell and tissue culture. In Protocols for Neural Cell Culture: Fourth Edition. Springer Protocols Handbooks. Pages: 175-191. DOI: 10.1007/978-1-60761-292-6_10
Protocols by Michel Cayouette
  1. Retinal Explant Culture
  2. Dissociated Retinal Cell Culture