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Garret A. FitzGerald

Education

MD, University College-Dublin, National University of Ireland, Dublin, Ireland, 1980

Current position

Professor of Medicine, Professor of Pharmacology, University of Pennsylvania, Philadelphia
Chairman, Department of Pharmacology, University of Pennsylvania
Director, Institute for Translational Medicine and Therapeutics, University of Pennsylvania Medical Center
Associate Dean for Translational Research, University of Pennsylvania
Robert L. McNeil, Jr. Professor in Translational Medicine and Therapeutics, University of Pennsylvania

Publications (since 2005)

  1. Bhala N., FitzGerald G. A., Baigent C. (2013). Vascular and upper gastrointestinal effects of non- steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet  (in press).
  2. Ramachandran, V. S., Ranchalis, J., Redline, S., Ridker, P. M., Rose, L. M., Scharnag, H., Schork, N. J., Shimbo, D., Shuldiner, A. R., Srinivasan, S. R., Stolk, R. P., Taylor, H. A., Thorand, B., Trip, M. D., van Duijn, C. M., Verschuren, W. M., Wijmenga, C., Winkelmann, B. R., Wyatt, S., Young, J. H., Boehm, B. O., Caulfield, M. J., Chasman, D. I., Davidson, K. W., Doevendans, P. A., Fitzgerald, G. A., Gums, J. G., Hakonarson, H., Hillege, H. L., Illig, T., Jarvik, G. P., Johnson, J. A., Kastelein, J. J., Koenig, W., Marz, W., Mitchell, B. D., Murray, S. S., Oldehinkel, A. J., Rader, D. J., Reilly, M. P., Reiner, A. P., Schadt, E. E., Silverstein, R. L., Snieder, H., Stanton, A. V., Uitterlinden, A. G., van der Harst, P., van der Schouw, Y. T., Samani, N. J., Johnson, A. D., Munroe, P. B., de Bakker, P. I., Zhu, X., Levy, D., Keating, B. J. and Asselbergs, F. W. (2013). Loci influencing blood pressure identified using a cardiovascular gene-centric array. Hum Mol Genet 22(8): 1663-1678.
  3. Ricciotti, E., Yu, Y., Grosser, T. and Fitzgerald, G. A. (2013). COX-2, the dominant source of prostacyclin. Proc Natl Acad Sci U S A 110(3): E183.
  4. Yu, Z., Ricciotti, E., Miwa, T., Liu, S., Ihida-Stansbury, K., Landersberg, G., Jones, P. L., Scalia, R., Song, W. C., Assoian, R. K. and FitzGerald, G. A. (2013). Myeloid cell 5-lipoxygenase activating protein modulates the response to vascular injury. Circ Res 112(3): 432-440.
  5. Chen, L., Yang, G., Xu, X., Grant, G., Lawson, J. A., Bohlooly, Y. M. and FitzGerald, G. A. (2013). Cell selective cardiovascular biology of microsomal prostaglandin E synthase-1. Circulation 127(2): 233-243.
  6. Nelson, A. M., Loy, D. E., Lawson, J. A., Katseff, A. S., Fitzgerald, G. A. and Garza, L. A. (2013). Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44. J Invest Dermatol 133(4): 881-889.
  7. Guo, Y., Lanktree, M. B., Taylor, K. C., Hakonarson, H., Lange, L. A. and Keating, B. J. (2013). Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. Hum Mol Genet 22(1): 184-201.
  8. Grosser, T., Fries, S., Lawson, J. A., Kapoor, S. C., Grant, G. R. and FitzGerald, G. A. (2013). Drug resistance and pseudoresistance: an unintended consequence of enteric coating aspirin. Circulation 127(3): 377-385.
  9. Lowell, A. N., Qiao, H., Liu, T., Ishikawa, T., Zhang, H., Oriana, S., Wang, M., Ricciotti, E., FitzGerald, G. A., Zhou, R. and Yamakoshi, Y. (2012). Functionalized low-density lipoprotein nanoparticles for in vivo enhancement of atherosclerosis on magnetic resonance images. Bioconjug Chem 23(11): 2313-2319
  10. Olson, M. T., Kickler, T. S., Lawson, J. A., McLean, R. C., Jani, J., FitzGerald, G. A. and Rade, J. J. (2012). Effect of assay specificity on the association of urine 11-dehydro thromboxane B2 determination with cardiovascular risk. J Thromb Haemost 10(12): 2462-2469.
  11. Paschos, G. K., Ibrahim, S., Song, W. L., Kunieda, T., Grant, G., Reyes, T. M., Bradfield, C. A., Vaughan, C. H., Eiden, M., Masoodi, M., Griffin, J. L., Wang, F., Lawson, J. A. and Fitzgerald, G. A. (2012). Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nat Med 18(12): 1768-1777.
  12. Grad, E., Pachino, R. M., FitzGerald, G. A. and Danenberg, H. D. (2012). Role of thromboxane receptor in C-reactive protein-induced thrombosis. Arterioscler Thromb Vasc Biol 32(10): 2468-2474.
  13. Saxena, R., Elbers, C. C., Guo, Y., Peter, I., Gaunt, T. R., Mega, J. L., Lanktree, M. B., Tare, A., Castillo, B. A., Li, Y. R., Johnson, T., Bruinenberg, M., Gilbert-Diamond, D., Rajagopalan, R., Voight, B. F., Balasubramanyam, A., Barnard, J., Bauer, F., Baumert, J., Bhangale, T., Bohm, B. O., Braund, P. S., Burton, P. R., Chandrupatla, H. R., Clarke, R., Cooper-DeHoff, R. M., Crook, E. D., Davey-Smith, G., Day, I. N., de Boer, A., de Groot, M. C., Drenos, F., Ferguson, J., Fox, C. S., Furlong, C. E., Gibson, Q., Gieger, C., Gilhuijs-Pederson, L. A., Glessner, J. T., Goel, A., Gong, Y., Grant, S. F., Grobbee, D. E., Hastie, C., Humphries, S. E., Kim, C. E., Kivimaki, M., Kleber, M., Meisinger, C., Kumari, M., Langaee, T. Y., Lawlor, D. A., Li, M., Lobmeyer, M. T., Maitland-van der Zee, A. H., Meijs, M. F., Molony, C. M., Morrow, D. A., Murugesan, G., Musani, S. K., Nelson, C. P., Newhouse, S. J., O'Connell, J. R., Padmanabhan, S., Palmen, J., Patel, S. R., Pepine, C. J., Pettinger, M., Price, T. S., Rafelt, S., Ranchalis, J., Rasheed, A., Rosenthal, E., Ruczinski, I., Shah, S., Shen, H., Silbernagel, G., Smith, E. N., Spijkerman, A. W., Stanton, A., Steffes, M. W., Thorand, B., Trip, M., van der Harst, P., van der, A. D., van Iperen, E. P., van Setten, J., van Vliet-Ostaptchouk, J. V., Verweij, N., Wolffenbuttel, B. H., Young, T., Zafarmand, M. H., Zmuda, J. M., Boehnke, M., Altshuler, D., McCarthy, M., Kao, W. H., Pankow, J. S., Cappola, T. P., Sever, P., Poulter, N., Caulfield, M., Dominiczak, A., Shields, D. C., Bhatt, D. L., Zhang, L., Curtis, S. P., Danesh, J., Casas, J. P., van der Schouw, Y. T., Onland-Moret, N. C., Doevendans, P. A., Dorn, G. W., 2nd, Farrall, M., FitzGerald, G. A., Hamsten, A., Hegele, R., Hingorani, A. D., Hofker, M. H., Huggins, G. S., Illig, T., Jarvik, G. P., Johnson, J. A., Klungel, O. H., Knowler, W. C., Koenig, W., Marz, W., Meigs, J. B., Melander, O., Munroe, P. B., Mitchell, B. D., Bielinski, S. J., Rader, D. J., Reilly, M. P., Rich, S. S., Rotter, J. I., Saleheen, D., Samani, N. J., Schadt, E. E., Shuldiner, A. R., Silverstein, R., Kottke-Marchant, K., Talmud, P. J., Watkins, H., Asselbergs, F. W., de Bakker, P. I., McCaffery, J., Wijmenga, C., Sabatine, M. S., Wilson, J. G., Reiner, A., Bowden, D. W., Hakonarson, H., Siscovick, D. S. and Keating, B. J. (2012). Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet 90(3): 410-425.
  14. Yu, Y., Ricciotti, E., Scalia, R., Tang, S. Y., Grant, G., Yu, Z., Landesberg, G., Crichton, I., Wu, W., Pure, E., Funk, C. D. and FitzGerald, G. A. (2012). Vascular COX-2 modulates blood pressure and thrombosis in mice. Sci Transl Med 4(132): 132ra154.
  15. Yu, Z., Crichton, I., Tang, S. Y., Hui, Y., Ricciotti, E., Levin, M. D., Lawson, J. A., Pure, E. and FitzGerald, G. A. (2012). Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice. Proc Natl Acad Sci U S A 109(17): 6727-6732.
  16. Zhou, W., Dowell, D. R., Huckabee, M. M., Newcomb, D. C., Boswell, M. G., Goleniewska, K., Lotz, M. T., Toki, S., Yin, H., Yao, S., Natarajan, C., Wu, P., Sriram, S., Breyer, R. M., Fitzgerald, G. A. and Peebles, R. S., Jr. (2012). Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitis. PLoS One 7(5): e33518.
  17. Dovizio, M., Tacconelli, S., Ricciotti, E., Bruno, A., Maier, T. J., Anzellotti, P., Di Francesco, L., Sala, P., Signoroni, S., Bertario, L., Dixon, D. A., Lawson, J. A., Steinhilber, D., FitzGerald, G. A. and Patrignani, P. (2012). Effects of celecoxib on prostanoid biosynthesis and circulating angiogenesis proteins in familial adenomatous polyposis. J Pharmacol Exp Ther 341(1): 242-250.
  18. Skarke, C., Alamuddin, N., Lawson, J. A., Cen, L., Propert, K. J. and Fitzgerald, G. A. (2012). Comparative impact on prostanoid biosynthesis of celecoxib and the novel nonsteroidal anti-inflammatory drug CG100649. Clin Pharmacol Ther 91(6): 986-993.
  19. Song, W.-L., Stubbe, J., Ricciotti, E., Alamuddin, N., Ibrahim, S., Crichton, I., Prempeh, M., Lawson, J. A., Wilensky, R. L. and Rasmussen, L. M. (2012). Niacin and biosynthesis of PGD2 by platelet COX-1 in mice and humans. The Journal of clinical investigation 122(4): 1459.
  20. Garza, L. A., Liu, Y., Yang, Z., Alagesan, B., Lawson, J. A., Norberg, S. M., Loy, D. E., Zhao, T., Blatt, H. B., Stanton, D. C., Carrasco, L., Ahluwalia, G., Fischer, S. M., FitzGerald, G. A. and Cotsarelis, G. (2012). Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. Sci Transl Med 4(126): 126ra134.
  21. Jaffar, Z., Ferrini, M. E., Shaw, P. K., FitzGerald, G. A. and Roberts, K. (2011). Prostaglandin I(2)promotes the development of IL-17-producing gammadelta T cells that associate with the epithelium during allergic lung inflammation. J Immunol 187(10): 5380-5391.
  22. Serrano, G. E., Lelutiu, N., Rojas, A., Cochi, S., Shaw, R., Makinson, C. D., Wang, D., FitzGerald, G. A. and Dingledine, R. (2011). Ablation of cyclooxygenase-2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus. J Neurosci 31(42): 14850-14860.
  23. Markosyan, N., Chen, E. P., Ndong, V. N., Yao, Y., Sterner, C. J., Chodosh, L. A., Lawson, J. A., Fitzgerald, G. A. and Smyth, E. M. (2011). Deletion of cyclooxygenase 2 in mouse mammary epithelial cells delays breast cancer onset through augmentation of type 1 immune responses in tumors. Carcinogenesis 32(10): 1441-1449.
  24. Winnik, S., Lohmann, C., Richter, E. K., Schafer, N., Song, W. L., Leiber, F., Mocharla, P., Hofmann, J., Klingenberg, R., Boren, J., Becher, B., Fitzgerald, G. A., Luscher, T. F., Matter, C. M. and Beer, J. H. (2011). Dietary alpha-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation. Eur Heart J 32(20): 2573-2584.
  25. Lanktree, M. B., Guo, Y., Murtaza, M., Glessner, J. T., Bailey, S. D., Onland-Moret, N. C., Lettre, G., Ongen, H., Rajagopalan, R., Johnson, T., Shen, H., Nelson, C. P., Klopp, N., Baumert, J., Padmanabhan, S., Pankratz, N., Pankow, J. S., Shah, S., Taylor, K., Barnard, J., Peters, B. J., Maloney, C. M., Lobmeyer, M. T., Stanton, A., Zafarmand, M. H., Romaine, S. P., Mehta, A., van Iperen, E. P., Gong, Y., Price, T. S., Smith, E. N., Kim, C. E., Li, Y. R., Asselbergs, F. W., Atwood, L. D., Bailey, K. M., Bhatt, D., Bauer, F., Behr, E. R., Bhangale, T., Boer, J. M., Boehm, B. O., Bradfield, J. P., Brown, M., Braund, P. S., Burton, P. R., Carty, C., Chandrupatla, H. R., Chen, W., Connell, J., Dalgeorgou, C., Boer, A., Drenos, F., Elbers, C. C., Fang, J. C., Fox, C. S., Frackelton, E. C., Fuchs, B., Furlong, C. E., Gibson, Q., Gieger, C., Goel, A., Grobbee, D. E., Hastie, C., Howard, P. J., Huang, G. H., Johnson, W. C., Li, Q., Kleber, M. E., Klein, B. E., Klein, R., Kooperberg, C., Ky, B., Lacroix, A., Lanken, P., Lathrop, M., Li, M., Marshall, V., Melander, O., Mentch, F. D., Meyer, N. J., Monda, K. L., Montpetit, A., Murugesan, G., Nakayama, K., Nondahl, D., Onipinla, A., Rafelt, S., Newhouse, S. J., Otieno, F. G., Patel, S. R., Putt, M. E., Rodriguez, S., Safa, R. N., Sawyer, D. B., Schreiner, P. J., Simpson, C., Sivapalaratnam, S., Srinivasan, S. R., Suver, C., Swergold, G., Sweitzer, N. K., Thomas, K. A., Thorand, B., Timpson, N. J., Tischfield, S., Tobin, M., Tomaszewski, M., Verschuren, W. M., Wallace, C., Winkelmann, B., Zhang, H., Zheng, D., Zhang, L., Zmuda, J. M., Clarke, R., Balmforth, A. J., Danesh, J., Day, I. N., Schork, N. J., de Bakker, P. I., Delles, C., Duggan, D., Hingorani, A. D., Hirschhorn, J. N., Hofker, M. H., Humphries, S. E., Kivimaki, M., Lawlor, D. A., Kottke-Marchant, K., Mega, J. L., Mitchell, B. D., Morrow, D. A., Palmen, J., Redline, S., Shields, D. C., Shuldiner, A. R., Sleiman, P. M., Smith, G. D., Farrall, M., Jamshidi, Y., Christiani, D. C., Casas, J. P., Hall, A. S., Doevendans, P. A., Christie, J. D., Berenson, G. S., Murray, S. S., Illig, T., Dorn, G. W., 2nd, Cappola, T. P., Boerwinkle, E., Sever, P., Rader, D. J., Reilly, M. P., Caulfield, M., Talmud, P. J., Topol, E., Engert, J. C., Wang, K., Dominiczak, A., Hamsten, A., Curtis, S. P., Silverstein, R. L., Lange, L. A., Sabatine, M. S., Trip, M., Saleheen, D., Peden, J. F., Cruickshanks, K. J., Marz, W., O'Connell, J. R., Klungel, O. H., Wijmenga, C., Maitland-van der Zee, A. H., Schadt, E. E., Johnson, J. A., Jarvik, G. P., Papanicolaou, G. J., Grant, S. F., Munroe, P. B., North, K. E., Samani, N. J., Koenig, W., Gaunt, T. R., Anand, S. S., van der Schouw, Y. T., Soranzo, N., Fitzgerald, G. A., Reiner, A., Hegele, R. A., Hakonarson, H. and Keating, B. J. (2011). Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet 88(1): 6-18.
  26. Wang, M., Ihida-Stansbury, K., Kothapalli, D., Tamby, M. C., Yu, Z., Chen, L., Grant, G., Cheng, Y., Lawson, J. A., Assoian, R. K., Jones, P. L. and Fitzgerald, G. A. (2011). Microsomal prostaglandin e2 synthase-1 modulates the response to vascular injury. Circulation 123(6): 631-639.
  27. Daham, K., Song, W. L., Lawson, J. A., Kupczyk, M., Gulich, A., Dahlen, S. E., FitzGerald, G. A. and Dahlen, B. (2011). Effects of celecoxib on major prostaglandins in asthma. Clin Exp Allergy 41(1): 36-45.
  28. Wang, M., Cooper, P. R., Jiang, M., Zhao, H., Hui, Y., Yao, Y., Tate, J. C., Damera, G., Lawson, J. A., Jester, W. F., Jr., Haczku, A., Panettieri, R. A., Jr. and FitzGerald, G. A. (2010). Deletion of microsomal prostaglandin E synthase-1 does not alter ozone-induced airway hyper-responsiveness. J Pharmacol Exp Ther 334(1): 63-68.
  29. Hui, Y., Ricciotti, E., Crichton, I., Yu, Z., Wang, D., Stubbe, J., Wang, M., Pure, E. and FitzGerald, G. A. (2010). Targeted deletions of cyclooxygenase-2 and atherogenesis in mice. Circulation 121(24): 2654-2660.
  30. Yu, Y., Stubbe, J., Ibrahim, S., Song, W. L., Smyth, E. M., Funk, C. D. and FitzGerald, G. A. (2010). Cyclooxygenase-2-dependent prostacyclin formation and blood pressure homeostasis: targeted exchange of cyclooxygenase isoforms in mice. Circ Res 106(2): 337-345.
  31. Grad, E., Golomb, M., Koroukhov, N., Lawson, J. A., Lotan, C., Fitzgerald, G. A. and Danenberg, H. D. (2009). Aspirin reduces the prothrombotic activity of C-reactive protein. J Thromb Haemost 7(8): 1393-1400.
  32. Song, W. L., Paschos, G., Fries, S., Reilly, M. P., Yu, Y., Rokach, J., Chang, C. T., Patel, P., Lawson, J. A. and Fitzgerald, G. A. (2009). Novel eicosapentaenoic acid-derived F3-isoprostanes as biomarkers of lipid peroxidation. J Biol Chem 284(35): 23636-23643.
  33. Wang, D., Patel, V. V., Ricciotti, E., Zhou, R., Levin, M. D., Gao, E., Yu, Z., Ferrari, V. A., Lu, M. M., Xu, J., Zhang, H., Hui, Y., Cheng, Y., Petrenko, N., Yu, Y. and FitzGerald, G. A. (2009). Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function. Proc Natl Acad Sci U S A 106(18): 7548-7552.
  34. Yu, Y., Lucitt, M. B., Stubbe, J., Cheng, Y., Friis, U. G., Hansen, P. B., Jensen, B. L., Smyth, E. M. and FitzGerald, G. A. (2009). Prostaglandin F2alpha elevates blood pressure and promotes atherosclerosis. Proc Natl Acad Sci U S A 106(19): 7985-7990.
  35. Baggs, J. E., Price, T. S., DiTacchio, L., Panda, S., Fitzgerald, G. A. and Hogenesch, J. B. (2009). Network features of the mammalian circadian clock. PLoS Biol 7(3): e52.
  36. Vardeh, D., Wang, D., Costigan, M., Lazarus, M., Saper, C. B., Woolf, C. J., Fitzgerald, G. A. and Samad, T. A. (2009). COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice. J Clin Invest 119(2): 287-294.
  37. Parastatidis, I., Thomson, L., Burke, A., Chernysh, I., Nagaswami, C., Visser, J., Stamer, S., Liebler, D. C., Koliakos, G., Heijnen, H. F., Fitzgerald, G. A., Weisel, J. W. and Ischiropoulos, H. (2008). Fibrinogen beta-chain tyrosine nitration is a prothrombotic risk factor. J Biol Chem 283(49): 33846-33853.
  38. Chang, C. T., Patel, P., Kang, N., Lawson, J. A., Song, W. L., Powell, W. S., FitzGerald, G. A. and Rokach, J. (2008). Eicosapentaenoic-acid-derived isoprostanes: synthesis and discovery of two major isoprostanes. Bioorg Med Chem Lett 18(20): 5523-5527.
  39. Price, T. S., Baggs, J. E., Curtis, A. M., Fitzgerald, G. A. and Hogenesch, J. B. (2008). WAVECLOCK: wavelet analysis of circadian oscillation. Bioinformatics 24(23): 2794-2795.
  40. Keating, B. J., Tischfield, S., Murray, S. S., Bhangale, T., Price, T. S., Glessner, J. T., Galver, L., Barrett, J. C., Grant, S. F., Farlow, D. N., Chandrupatla, H. R., Hansen, M., Ajmal, S., Papanicolaou, G. J., Guo, Y., Li, M., Derohannessian, S., de Bakker, P. I., Bailey, S. D., Montpetit, A., Edmondson, A. C., Taylor, K., Gai, X., Wang, S. S., Fornage, M., Shaikh, T., Groop, L., Boehnke, M., Hall, A. S., Hattersley, A. T., Frackelton, E., Patterson, N., Chiang, C. W., Kim, C. E., Fabsitz, R. R., Ouwehand, W., Price, A. L., Munroe, P., Caulfield, M., Drake, T., Boerwinkle, E., Reich, D., Whitehead, A. S., Cappola, T. P., Samani, N. J., Lusis, A. J., Schadt, E., Wilson, J. G., Koenig, W., McCarthy, M. I., Kathiresan, S., Gabriel, S. B., Hakonarson, H., Anand, S. S., Reilly, M., Engert, J. C., Nickerson, D. A., Rader, D. J., Hirschhorn, J. N. and Fitzgerald, G. A. (2008). Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One 3(10): e3583.
  41. Westgate, E. J., Cheng, Y., Reilly, D. F., Price, T. S., Walisser, J. A., Bradfield, C. A. and FitzGerald, G. A. (2008). Genetic components of the circadian clock regulate thrombogenesis in vivo. Circulation 117(16): 2087-2095.
  42. Ky, B., Burke, A., Tsimikas, S., Wolfe, M. L., Tadesse, M. G., Szapary, P. O., Witztum, J. L., FitzGerald, G. A. and Rader, D. J. (2008). The influence of pravastatin and atorvastatin on markers of oxidative stress in hypercholesterolemic humans. J Am Coll Cardiol 51(17): 1653-1662.
  43. Chen, M., Boilard, E., Nigrovic, P. A., Clark, P., Xu, D., Fitzgerald, G. A., Audoly, L. P. and Lee, D. M. (2008). Predominance of cyclooxygenase 1 over cyclooxygenase 2 in the generation of proinflammatory prostaglandins in autoantibody-driven K/BxN serum-transfer arthritis. Arthritis Rheum 58(5): 1354-1365.
  44. Lucitt, M. B., Price, T. S., Pizarro, A., Wu, W., Yocum, A. K., Seiler, C., Pack, M. A., Blair, I. A., Fitzgerald, G. A. and Grosser, T. (2008). Analysis of the zebrafish proteome during embryonic development. Mol Cell Proteomics 7(5): 981-994.
  45. Kunieda, T., Minamino, T., Miura, K., Katsuno, T., Tateno, K., Miyauchi, H., Kaneko, S., Bradfield, C. A., FitzGerald, G. A. and Komuro, I. (2008). Reduced nitric oxide causes age-associated impairment of circadian rhythmicity. Circ Res 102(5): 607-614.
  46. Reilly, D. F., Curtis, A. M., Cheng, Y., Westgate, E. J., Rudic, R. D., Paschos, G., Morris, J., Ouyang, M., Thomas, S. A. and FitzGerald, G. A. (2008). Peripheral circadian clock rhythmicity is retained in the absence of adrenergic signaling. Arterioscler Thromb Vasc Biol 28(1): 121-126.
  47. Wang, M., Lee, E., Song, W., Ricciotti, E., Rader, D. J., Lawson, J. A., Pure, E. and FitzGerald, G. A. (2008). Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation. Circulation 117(10): 1302-1309.
  48. Song, W. L., Wang, M., Ricciotti, E., Fries, S., Yu, Y., Grosser, T., Reilly, M., Lawson, J. A. and FitzGerald, G. A. (2008). Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans. J Biol Chem 283(2): 1179-1188.
  49. Song, W. L., Lawson, J. A., Reilly, D., Rokach, J., Chang, C. T., Giasson, B. and FitzGerald, G. A. (2008). Neurofurans, novel indices of oxidant stress derived from docosahexaenoic acid. J Biol Chem 283(1): 6-16.
  50. Jaffar, Z., Ferrini, M. E., Buford, M. C., Fitzgerald, G. A. and Roberts, K. (2007). Prostaglandin I2-IP signaling blocks allergic pulmonary inflammation by preventing recruitment of CD4+ Th2 cells into the airways in a mouse model of asthma. J Immunol 179(9): 6193-6203.
  51. Huang, J. C., Wun, W. S., Goldsby, J. S., Egan, K., FitzGerald, G. A. and Wu, K. K. (2007). Prostacyclin receptor signaling and early embryo development in the mouse. Hum Reprod 22(11): 2851-2856.
  52. Wada, M., DeLong, C. J., Hong, Y. H., Rieke, C. J., Song, I., Sidhu, R. S., Yuan, C., Warnock, M., Schmaier, A. H., Yokoyama, C., Smyth, E. M., Wilson, S. J., FitzGerald, G. A., Garavito, R. M., Sui de, X., Regan, J. W. and Smith, W. L. (2007). Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products. J Biol Chem 282(31): 22254-22266.
  53. Chou, W. L., Chuang, L. M., Chou, C. C., Wang, A. H., Lawson, J. A., FitzGerald, G. A. and Chang, Z. F. (2007). Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation. J Biol Chem 282(25): 18162-18172.
  54. North, T. E., Goessling, W., Walkley, C. R., Lengerke, C., Kopani, K. R., Lord, A. M., Weber, G. J., Bowman, T. V., Jang, I. H., Grosser, T., Fitzgerald, G. A., Daley, G. Q., Orkin, S. H. and Zon, L. I. (2007). Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature 447(7147): 1007-1011.
  55. Zhou, W., Blackwell, T. S., Goleniewska, K., O'Neal, J. F., Fitzgerald, G. A., Lucitt, M., Breyer, R. M. and Peebles, R. S., Jr. (2007). Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells. J Leukoc Biol 81(3): 809-817.
  56. Zhou, W., Hashimoto, K., Goleniewska, K., O'Neal, J. F., Ji, S., Blackwell, T. S., Fitzgerald, G. A., Egan, K. M., Geraci, M. W. and Peebles, R. S., Jr. (2007). Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells. J Immunol 178(2): 702-710.
  57. Garcia Rodriguez, L. A., Egan, K. and FitzGerald, G. A. (2007). Traditional nonsteroidal anti-inflammatory drugs and postmenopausal hormone therapy: a drug-drug interaction? PLoS Med 4(5): e157.
  58. Yu, Y., Fan, J., Hui, Y., Rouzer, C. A., Marnett, L. J., Klein-Szanto, A. J., FitzGerald, G. A. and Funk, C. D. (2007). Targeted cyclooxygenase gene (ptgs) exchange reveals discriminant isoform functionality. J Biol Chem 282(2): 1498-1506.
  59. Price, T. S., Lucitt, M. B., Wu, W., Austin, D. J., Pizarro, A., Yocum, A. K., Blair, I. A., FitzGerald, G. A. and Grosser, T. (2007). EBP, a program for protein identification using multiple tandem mass spectrometry datasets. Mol Cell Proteomics 6(3): 527-536.
  60. Curtis, A. M., Cheng, Y., Kapoor, S., Reilly, D., Price, T. S. and Fitzgerald, G. A. (2007). Circadian variation of blood pressure and the vascular response to asynchronous stress. Proc Natl Acad Sci U S A 104(9): 3450-3455.
  61. Cannon, C. P., Curtis, S. P., FitzGerald, G. A., Krum, H., Kaur, A., Bolognese, J. A., Reicin, A. S., Bombardier, C., Weinblatt, M. E., van der Heijde, D., Erdmann, E. and Laine, L. (2006). Cardiovascular outcomes with etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison. Lancet 368(9549): 1771-1781.
  62. Lawson, J. A., Kim, S., Powell, W. S., FitzGerald, G. A. and Rokach, J. (2006). Oxidized derivatives of omega-3 fatty acids: identification of IPF3 alpha-VI in human urine. J Lipid Res 47(11): 2515-2524.
  63. Wang, M., Zukas, A. M., Hui, Y., Ricciotti, E., Pure, E. and FitzGerald, G. A. (2006). Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis. Proc Natl Acad Sci U S A 103(39): 14507-14512.
  64. Yu, Y., Fan, J., Chen, X. S., Wang, D., Klein-Szanto, A. J., Campbell, R. L., FitzGerald, G. A. and Funk, C. D. (2006). Genetic model of selective COX2 inhibition reveals novel heterodimer signaling. Nat Med 12(6): 699-704.
  65. Jacobo, S. H., Chang, C. T., Lee, G. J., Lawson, J. A., Powell, W. S., Pratico, D., FitzGerald, G. A. and Rokach, J. (2006). Total synthesis of 8,12-iso-iPF3alpha-VI, an EPA-derived isoprostane: stereoselective introduction of the fifth asymmetric center. J Org Chem 71(4): 1370-1379.
  66. Lovgren, A. K., Jania, L. A., Hartney, J. M., Parsons, K. K., Audoly, L. P., Fitzgerald, G. A., Tilley, S. L. and Koller, B. H. (2006). COX-2-derived prostacyclin protects against bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 291(2): L144-156.
  67. Cheng, Y., Wang, M., Yu, Y., Lawson, J., Funk, C. D. and Fitzgerald, G. A. (2006). Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function. J Clin Invest 116(5): 1391-1399.
  68. Woon, P. Y., Curtis, A. M., Kaisaki, P. J., Argoud, K., Wallace, K. J., Bihoreau, M. T., FitzGerald, G. A. and Gauguier, D. (2006). Genomic organization of the rat Clock gene and sequence analysis in inbred rat strains. Genomics 87(2): 208-217.
  69. Ali, F. Y., Egan, K., FitzGerald, G. A., Desvergne, B., Wahli, W., Bishop-Bailey, D., Warner, T. D. and Mitchell, J. A. (2006). Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts. Am J Respir Cell Mol Biol 34(2): 242-246.
  70. Fries, S., Grosser, T., Price, T. S., Lawson, J. A., Kapoor, S., DeMarco, S., Pletcher, M. T., Wiltshire, T. and FitzGerald, G. A. (2006). Marked interindividual variability in the response to selective inhibitors of cyclooxygenase-2. Gastroenterology 130(1): 55-64.
  71. Francois, H., Athirakul, K., Howell, D., Dash, R., Mao, L., Kim, H. S., Rockman, H. A., Fitzgerald, G. A., Koller, B. H. and Coffman, T. M. (2005). Prostacyclin protects against elevated blood pressure and cardiac fibrosis. Cell Metab 2(3): 201-207.
  72. Rudic, R. D., McNamara, P., Reilly, D., Grosser, T., Curtis, A. M., Price, T. S., Panda, S., Hogenesch, J. B. and FitzGerald, G. A. (2005). Bioinformatic analysis of circadian gene oscillation in mouse aorta. Circulation 112(17): 2716-2724.
  73. Chang, C.-T., Jacobo, S. H., Powell, W. S., Lawson, J. A., FitzGerald, G. A., Pratico, D. and Rokach, J. (2005). A new synthetic approach for 4 (< i> S)-hydroxycyclopent-2-enone: a precursor to prostanoid synthesis. Tetrahedron letters 46(37): 6325-6328.
  74. Westgate, E. J. and Fitzgerald, G. A. (2005). Pulmonary embolism in a woman taking oral contraceptives and valdecoxib. PLoS Med 2(7): e197.
  75. Rudic, R. D., Brinster, D., Cheng, Y., Fries, S., Song, W. L., Austin, S., Coffman, T. M. and FitzGerald, G. A. (2005). COX-2-derived prostacyclin modulates vascular remodeling. Circ Res 96(12): 1240-1247.
  76. Yu, Y., Cheng, Y., Fan, J., Chen, X. S., Klein-Szanto, A., Fitzgerald, G. A. and Funk, C. D. (2005). Differential impact of prostaglandin H synthase 1 knockdown on platelets and parturition. J Clin Invest 115(4): 986-995.
  77. Kim, S., Powell, W. S., Lawson, J. A., Jacobo, S. H., Pratico, D., FitzGerald, G. A., Maxey, K. and Rokach, J. (2005). iPF2alpha-III-17,18,19,20-d4: total synthesis and metabolism. Bioorg Med Chem Lett 15(6): 1613-1617.
  78. Furberg, C. D., Psaty, B. M. and FitzGerald, G. A. (2005). Parecoxib, valdecoxib, and cardiovascular risk. Circulation 111(3): 249.
  79. Pini, B., Grosser, T., Lawson, J. A., Price, T. S., Pack, M. A. and FitzGerald, G. A. (2005). Prostaglandin E synthases in zebrafish. Arterioscler Thromb Vasc Biol 25(2): 315-320.
  80. Egan, K. M., Wang, M., Fries, S., Lucitt, M. B., Zukas, A. M., Pure, E., Lawson, J. A. and FitzGerald, G. A. (2005). Cyclooxygenases, thromboxane, and atherosclerosis: plaque destabilization by cyclooxygenase-2 inhibition combined with thromboxane receptor antagonism. Circulation 111(3): 334-342.
Protocols by Garret A. FitzGerald
  1. Insulin Tolerance Test and Hyperinsulinemic-euglycemic Clamp