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Michael J. Federle

Education

Ph.D. in Microbiology and Molecular Genetics, Emory University, Atlanta, GA, 2002

Current position

Assistant Professor, Center for Pharmaceutical Biotechnology, Dept. of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago

Publications

  1. LaSarre, B. and Federle, M. J. (2013). Exploiting quorum sensing to confuse bacterial pathogens. Microbiol Mol Biol Rev 77(1): 73-111.
  2. Aggarwal, C and Federle, M. J. Peptide pheromones and their protein receptors: Cellular signaling in Gram-positive bacteria. Encyclopedia of Molecular Life Sciences. Submitted.
  3. Lasarre, B., Aggarwal, C. and Federle, M. J. (2013). Antagonistic Rgg regulators mediate quorum sensing via competitive DNA binding in Streptococcus pyogenes. MBio 3(6).
  4. Federle, M. J. and Morrison, D. A. (2012). One if by land, two if by sea: signalling to the ranks with CSP and XIP. Mol Microbiol 86(2): 241-245.
  5. Mashburn-Warren, L., Morrison, D. A. and Federle, M. J. (2012). The cryptic competence pathway in Streptococcus pyogenes is controlled by a peptide pheromone. J Bacteriol 194(17): 4589-4600.
  6. Federle, M. J. and Morrison, D. A. (2012). One if by land, two if by sea: signalling to the ranks with CSP and XIP. Mol Microbiol 86(2): 241-245.
  7. Mashburn-Warren, L., Morrison, D. A. and Federle, M. J. (2012). The cryptic competence pathway in Streptococcus pyogenes is controlled by a peptide pheromone. J Bacteriol 194(17): 4589-4600.
  8. Desai, K., Mashburn-Warren, L., Federle, M. J. and Morrison, D. A. (2012). Development of competence for genetic transformation of Streptococcus mutans in a chemically defined medium. J Bacteriol 194(15): 3774-3780.
  9. Federle, M. (2012). Pathogenic streptococci speak, but what are they saying? Virulence 3(1): 92-94.
  10. Chang, J. C., LaSarre, B., Jimenez, J. C., Aggarwal, C. and Federle, M. J. (2011). Two group A streptococcal peptide pheromones act through opposing Rgg regulators to control biofilm development. PLoS Pathog 7(8): e1002190.
  11. LaSarre, B. and Federle, M. J. (2011). Regulation and consequence of serine catabolism in Streptococcus pyogenes. J Bacteriol 193(8): 2002-2012.
  12. Mashburn-Warren, L., Morrison, D. A. and Federle, M. J. (2010). A novel double-tryptophan peptide pheromone controls competence in Streptococcus spp. via an Rgg regulator. Mol Microbiol 78(3): 589-606.
  13. Federle, M. J. (2009). Autoinducer-2-based chemical communication in bacteria: complexities of interspecies signaling. Contrib Microbiol 16: 18-32.
  14. Neiditch, M. B., Federle, M. J., Pompeani, A. J., Kelly, R. C., Swem, D. L., Jeffrey, P. D., Bassler, B. L. and Hughson, F. M. (2006). Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing. Cell 126(6): 1095-1108.
  15. Neiditch, M. B., Federle, M. J., Miller, S. T., Bassler, B. L. and Hughson, F. M. (2005). Regulation of LuxPQ receptor activity by the quorum-sensing signal autoinducer-2. Mol Cell 18(5): 507-518.
  16. Semmelhack, M. F., Campagna, S. R., Federle, M. J. and Bassler, B. L. (2005). An expeditious synthesis of DPD and boron binding studies. Org Lett 7(4): 569-572.
  17. Semmelhack, M. F., Campagna, S. R., Hwa, C., Federle, M. J. and Bassler, B. L. (2004). Boron binding with the quorum sensing signal AI-2 and analogues. Org Lett 6(15): 2635-2637.
  18. Federle, M. J. and Bassler, B. L. (2003). Interspecies communication in bacteria. J Clin Invest 112(9): 1291-1299.
  19. Federle, M. J. and Scott, J. R. (2002). Identification of binding sites for the group A streptococcal global regulator CovR. Mol Microbiol 43(5): 1161-1172.
  20. Graham, M. R., Smoot, L. M., Migliaccio, C. A., Virtaneva, K., Sturdevant, D. E., Porcella, S. F., Federle, M. J., Adams, G. J., Scott, J. R. and Musser, J. M. (2002). Virulence control in group A Streptococcus by a two-component gene regulatory system: global expression profiling and in vivo infection modeling. Proc Natl Acad Sci U S A 99(21): 13855-13860.
  21. Lei, B., DeLeo, F. R., Hoe, N. P., Graham, M. R., Mackie, S. M., Cole, R. L., Liu, M., Hill, H. R., Low, D. E., Federle, M. J., Scott, J. R. and Musser, J. M. (2001). Evasion of human innate and acquired immunity by a bacterial homolog of CD11b that inhibits opsonophagocytosis. Nat Med 7(12): 1298-1305.
  22. Federle, M. J., McIver, K. S. and Scott, J. R. (1999). A response regulator that represses transcription of several virulence operons in the group A streptococcus. J Bacteriol 181(12): 3649-3657.
  23. Eichenbaum, Z., Federle, M. J., Marra, D., de Vos, W. M., Kuipers, O. P., Kleerebezem, M. and Scott, J. R. (1998). Use of the lactococcal nisA promoter to regulate gene expression in gram-positive bacteria: comparison of induction level and promoter strength. Appl Environ Microbiol 64(8): 2763-2769.
Protocols by Michael J. Federle
  1. EMSA Analysis of DNA Binding By Rgg Proteins