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Vaibhav B. Shah

Education

Ph.D. in Molecular Pharmacology/Signal Transduction, School of Pharmacy, Ohio State University, USA , 2009

Current position

Post-doctoral Research Fellow, Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, USA

Publications

Referred journal articles

  1. Hauler, F., McEwan, W.A., Watkinson, R.E., Jacques, D.A., Guo, A., Shah, V.B., Aiken, C., James, L. (2013). The ATPase p97/VCP catalyzes HIV-1 uncoating. Nature In Press
  2. Lamorte, L., Titolo, S., Lemke, C. T., Goudreau, N., Mercier, J.-F., Wardrop, E., Shah, V. B., von Schwedler, U. K., Langelier, C. and Banik, S. S. (2013). Discovery of novel small-molecule HIV-1 replication inhibitors that stabilize capsid complexes. Antimicrob Agents Chemother 57(10): 4622-4631.
  3. Mathew, S., Nguyen, M., Wu, X., Pal, A., Shah, V. B., Prasad, V. R., Aiken, C. and Kalpana, G. V. (2013). INI1/hSNF5-interaction defective HIV-1 IN mutants exhibit impaired particle morphology, reverse transcription and integration in vivo. Retrovirology 10: 66.
  4. Shah, V. B., Shi, J., Hout, D. R., Oztop, I., Krishnan, L., Ahn, J., Shotwell, M. S., Engelman, A. and Aiken, C. (2013). The host proteins transportin SR2/TNPO3 and cyclophilin A exert opposing effects on HIV-1 uncoating. J Virol 87(1): 422-432.
  5. Shah, V. B. and Aiken, C. (2011). In vitro uncoating of HIV-1 cores. J Vis Exp(57).
  6. Zhao, G., Ke, D., Vu, T., Ahn, J., Shah, V. B., Yang, R., Aiken, C., Charlton, L. M., Gronenborn, A. M. and Zhang, P. (2011). Rhesus TRIM5α disrupts the HIV-1 capsid at the inter-hexamer interfaces. PLoS Pathog 7(3): e1002009.
  7. Shi, J., Zhou, J., Shah, V. B., Aiken, C. and Whitby, K. (2011). Small-molecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilization. J Virol 85(1): 542-549.
  8. Shah, V. B. and Aiken, C. (2010). HIV Nuclear Entry: Clearing the Fog. Viruses 2(5): 1190-1194.
  9. Liu, T., Schneider, R. A., Shah, V., Huang, Y., Likhotvorik, R. I., Keshvara, L. and Hoyt, D. G. (2009). Protein Never in Mitosis Gene A Interacting-1 regulates calpain activity and the degradation of cyclooxygenase-2 in endothelial cells. J Inflamm (Lond) 6: 20.
  10. Shah, V. B., Williams, D. L. and Keshvara, L. (2009). β-Glucan attenuates TLR2- and TLR4-mediated cytokine production by microglia. Neurosci Lett 458(3): 111-115.
  11. Shah, V. B., Ozment-Skelton, T. R., Williams, D. L. and Keshvara, L. (2009). Vav1 and PI3K are required for phagocytosis of β-glucan and subsequent superoxide generation by microglia. Mol Immunol 46(8-9): 1845-1853.
  12. Shah, V. B., Huang, Y., Keshwara, R., Ozment-Skelton, T., Williams, D. L. and Keshvara, L. (2008). β-glucan activates microglia without inducing cytokine production in Dectin-1-dependent manner. J Immunol 180(5): 2777-2785.
  13. Huang, Y., Shah, V., Liu, T. and Keshvara, L. (2005). Signaling through Disabled 1 requires phosphoinositide binding. Biochem Biophys Res Commun 331(4): 1460-1468.

Book chapters

  1. Shah, V.B. and Aiken, C. Uncoating and Nuclear Import. In: Encyclopedia of AIDS. Hope T, Richman D, Stevenson M. (eds). Springer publication In press
Protocols by Vaibhav B. Shah
  1. Cell Fractionation and Quantitative Analysis of HIV-1 Reverse Transcription in Target Cells