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Herbert Schwarz

Education

Ph.D. in Genetics, Department of Neurogenetics, University of Wuerzburg, Germany, 1989

Current Position

Associate Professor, Department of Physiology, National University of Singapore, Singapore

Publications (since 2005)

  1. Moh, M. C., Lorenzini, P. A., Gullo, C. and Schwarz, H. (2013). Tumor necrosis factor receptor 1 associates with CD137 ligand and mediates its reverse signaling. FASEB J. [Epub ahead of print]
  2. Tang, Q., Jiang, D., Alonso, S., Pant, A., Martinez Gomez, J. M., Kemeny, D. M., Chen, L. and Schwarz, H. (2013). CD137 ligand signaling enhances myelopoiesis during infections. Eur J Immunol. [Epub ahead of print]
  3. Ho, W. T., Pang, W. L., Chong, S. M., Castella, A., Al-Salam, S., Tan, T. E., Moh, M. C., Koh, L. K., Gan, S. U., Cheng, C. K. and Schwarz, H. (2013). Expression of CD137 on Hodgkin and Reed-Sternberg cells inhibits T-cell activation by eliminating CD137 ligand expression. Cancer Res 73(2): 652-661.
  4. Martinez Gomez, J. M., Croxford, J. L., Yeo, K. P., Angeli, V., Schwarz, H. and Gasser, S. (2012). Development of experimental autoimmune encephalomyelitis critically depends on CD137 ligand signaling. J Neurosci 32(50): 18246-18252.
  5. Yeo, Y. A., Martinez Gomez, J. M., Croxford, J. L., Gasser, S., Ling, E. A. and Schwarz, H. (2012). CD137 ligand activated microglia induces oligodendrocyte apoptosis via reactive oxygen species. J Neuroinflammation 9: 173.
  6. Ong, S. M., Tan, Y. C., Beretta, O., Jiang, D., Yeap, W. H., Tai, J. J., Wong, W. C., Yang, H., Schwarz, H., Lim, K. H., Koh, P. K., Ling, K. L. and Wong, S. C. (2012). Macrophages in human colorectal cancer are pro-inflammatory and prime T cells towards an anti-tumour type-1 inflammatory response. Eur J Immunol 42(1): 89-100.
  7. Jiang, D., Tang, Q. and Schwarz, H. (2011). Involvement of the cytokine receptor CD137 in murine hematopoiesis. Adv Exp Med Biol 691: 375-382.
  8. Shao, Z. and Schwarz, H. (2011). CD137 ligand, a member of the tumor necrosis factor family, regulates immune responses via reverse signal transduction. J Leukoc Biol 89(1): 21-29.
  9. S Shao, Z., Schaffler, A., Hamer, O., Dickopf, J., Goetz, A., Landfried, K., Voelk, M., Kopp, A., Herfarth, H., Karrasch, T., Brunnler, T., Koh, L. K., Buechler, C. and Schwarz, H. (2012). Admission levels of soluble CD137 are increased in patients with acute pancreatitis and are associated with subsequent complications. Exp Mol Pathol 92(1): 1-6.
  10. Kwajah, M. M. S., Mustafa, N., Holme, A. L., Pervaiz, S. and Schwarz, H. (2011). Biphasic activity of CD137 ligand-stimulated monocytes on T cell apoptosis and proliferation. J Leukoc Biol 89(5): 707-720.
  11. Tang, Q., Jiang, D., Shao, Z., Martinez Gomez, J. M. and Schwarz, H. (2011). Species difference of CD137 ligand signaling in human and murine monocytes. PLoS One 6(1): e16129.
  12. Jiang, D. and Schwarz, H. (2010). Regulation of granulocyte and macrophage populations of murine bone marrow cells by G-CSF and CD137 protein. PLoS One 5(12): e15565.
  13. Kwajah, M. M. S. and Schwarz, H. (2010). CD137 ligand signaling induces human monocyte to dendritic cell differentiation. Eur J Immunol 40(7): 1938-1949.
  14. Gullo, C., Koh, L. K., Pang, W. L., Ho, K. T., Tan, S. H. and Schwarz, H. (2010). Inhibition of proliferation and induction of apoptosis in multiple myeloma cell lines by CD137 ligand signaling. PLoS One 5(5): e10845.
  15. Quek, B. Z., Lim, Y. C., Lin, J. H., Tan, T. E., Chan, J., Biswas, A. and Schwarz, H. (2010). CD137 enhances monocyte-ICAM-1 interactions in an E-selectin-dependent manner under flow conditions. Mol Immunol 47(9): 1839-1847.
  16. Thum, E., Shao, Z. and Schwarz, H. (2009). CD137, implications in immunity and potential for therapy. Front Biosci 14: 4173-4188.
  17. Wang, Z., Chen, C., Finger, S. N., Kwajah, S., Jung, M., Schwarz, H., Swanson, N., Lareu, F. F. and Raghunath, M. (2009). Suberoylanilide hydroxamic acid: a potential epigenetic therapeutic agent for lung fibrosis? Eur Respir J 34(1): 145-155.
  18. Jiang, D., Chen, Y. and Schwarz, H. (2008). CD137 induces proliferation of murine hematopoietic progenitor cells and differentiation to macrophages. J Immunol 181(6): 3923-3932.
  19. Jiang, D., Yue, P. S., Drenkard, D. and Schwarz, H. (2008). Induction of proliferation and monocytic differentiation of human CD34+ cells by CD137 ligand signaling. Stem Cells 26(9): 2372-2381.
  20. hao, Z., Sun, F., Koh, D. R. and Schwarz, H. (2008). Characterisation of soluble murine CD137 and its association with systemic lupus. Mol Immunol 45(15): 3990-3999.
  21. Lippert, U., Zachmann, K., Ferrari, D. M., Schwarz, H., Brunner, E., Latif, A., Neumann, C. and Soruri, A. (2008). CD137 ligand reverse signaling has multiple functions in human dendritic cells during an adaptive immune response. Eur J Immunol 38(4): 1024-1032.
  22. Sollner, L., Shaqireen, D. O. K. M. M., Wu, J. T. and Schwarz, H. (2007). Signal transduction mechanisms of CD137 ligand in human monocytes. Cell Signal 19(9): 1899-1908.
  23. Drenkard, D., Becke, F. M., Langstein, J., Spruss, T., Kunz-Schughart, L. A., Tan, T. E., Lim, Y. C. and Schwarz, H. (2007). CD137 is expressed on blood vessel walls at sites of inflammation and enhances monocyte migratory activity. FASEB J 21(2): 456-463.
  24. Schwarz H. Significance of reverse signal transduction for the biology of the CD137 receptor/ligand system. In: Chen LP (Ed.). CD137/4-1BB Pathway in Immune Responses and Diseases. Kluwer Academic/Plenum Publishers 2006.
  25. Yu, Q., Yue, F. Y., Gu, X. X., Schwartz, H., Kovacs, C. M. and Ostrowski, M. A. (2006). OX40 ligation of CD4+ T cells enhances virus-specific CD8+ T cell memory responses independently of IL-2 and CD4+ T regulatory cell inhibition. J Immunol 176(4): 2486-2495.
  26. Ierna, M. X., Scales, H. E., Schwarz, H., Bunce, C., McIlgorm, A., Garside, P. and Lawrence, C. E. (2006). OX40 interactions in gastrointestinal nematode infection. Immunology 117(1): 108-116.
  27. Reali C, Scintu F, Pillai R, Curto M, Palmieri G, Marcialis MA, Schwarz H and Sogos V. Expression of Cytokines and Co-stimulatory Molecules by Activated Human Microglia. In Robert M Coleman (Ed.). Focus on Neurochemistry. Nova Science Publishers, Inc. 2005 pp 117- 40. 
  28. Schwarz, H. (2005). Biological activities of reverse signal transduction through CD137 ligand. Journal of leukocyte biology 77(3): 281-286.
  29. Furtner, M., Straub, R. H., Kruger, S. and Schwarz, H. (2005). Levels of soluble CD137 are enhanced in sera of leukemia and lymphoma patients and are strongly associated with chronic lymphocytic leukemia. Leukemia 19(5): 883-885.
Protocols by Herbert Schwarz
  1. Isolation of Infiltrating Leukocytes from the Spinal Cord of Mice