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Yvan Canitrot


Ph.D. in Biology, Laboratory of Physical-Chemistry, Perpignan University, France, 1994

Current position

Senior Researcher (CNRS), Laboratory of Molecular and Cell Biology of Proliferation Control, UMR 5088, P. Sabatier University, Toulouse, France

Publications (since 2005)

  1. Lai, Z., Moravcova, S., Canitrot, Y., Andrzejewski, L. P., Walshe, D. M. and Rea, S. (2013). Msl2 is a novel component of the vertebrate DNA damage response. PLoS One 8(7): e68549.
  2. Courilleau, C., Chailleux, C., Jauneau, A., Grimal, F., Briois, S., Boutet-Robinet, E., Boudsocq, F., Trouche, D. and Canitrot, Y. (2012). The chromatin remodeler p400 ATPase facilitates Rad51-mediated repair of DNA double-strand breaks. J Cell Biol 199(7): 1067-1081.
  3. Caron, P., Aymard, F., Iacovoni, J. S., Briois, S., Canitrot, Y., Bugler, B., Massip, L., Losada, A. and Legube, G. (2012). Cohesin protects genes against gammaH2AX Induced by DNA double-strand breaks. PLoS Genet 8(1): e1002460.
  4. Capp, J. P., Boudsocq, F., Bergoglio, V., Trouche, D., Cazaux, C., Blanco, L., Hoffmann, J. S. and Canitrot, Y. (2010). The R438W polymorphism of human DNA polymerase lambda triggers cellular sensitivity to camptothecin by compromising the homologous recombination repair pathway. Carcinogenesis 31(10): 1742-1747.
  5. Mattera, L., Courilleau, C., Legube, G., Ueda, T., Fukunaga, R., Chevillard-Briet, M., Canitrot, Y., Escaffit, F. and Trouche, D. (2010). The E1A-associated p400 protein modulates cell fate decisions by the regulation of ROS homeostasis. PLoS Genet 6(6): e1000983.
  6. Chailleux, C., Tyteca, S., Papin, C., Boudsocq, F., Puget, N., Courilleau, C., Grigoriev, M., Canitrot, Y. and Trouche, D. (2010). Physical interaction between the histone acetyl transferase Tip60 and the DNA double-strand breaks sensor MRN complex. Biochem J 426(3): 365-371.
  7. Terrados, G., Capp, J. P., Canitrot, Y., Garcia-Diaz, M., Bebenek, K., Kirchhoff, T., Villanueva, A., Boudsocq, F., Bergoglio, V., Cazaux, C., Kunkel, T. A., Hoffmann, J. S. and Blanco, L. (2009). Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ. PLoS One 4(10): e7290.
  8. Faumont, N., Le Clorennec, C., Teira, P., Goormachtigh, G., Coll, J., Canitrot, Y., Cazaux, C., Hoffmann, J. S., Brousset, P., Delsol, G., Feuillard, J. and Meggetto, F. (2009). Regulation of DNA polymerase beta by the LMP1 oncoprotein of EBV through the nuclear factor-kappaB pathway. Cancer Res 69(12): 5177-5185.
  9. Lopes, D. O., Falconi, F. C., Goes, A. M., Canitrot, Y., Hoffmann, J. S., Cazaux, C., Franco, G. R., Macedo, A. M., Pena, S. D. and Machado, C. R. (2009). Isolation and characterization of HC1: a novel human DNA repair gene. Genet Mol Res 8(1): 247-260.
  10. Capp, J. P., Boudsocq, F., Besnard, A. G., Lopez, B. S., Cazaux, C., Hoffmann, J. S. and Canitrot, Y. (2007). Involvement of DNA polymerase mu in the repair of a specific subset of DNA double-strand breaks in mammalian cells. Nucleic Acids Res 35(11): 3551-3560.
  11. Capp, J. P., Boudsocq, F., Bertrand, P., Laroche-Clary, A., Pourquier, P., Lopez, B. S., Cazaux, C., Hoffmann, J. S. and Canitrot, Y. (2006). The DNA polymerase lambda is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells. Nucleic Acids Res 34(10): 2998-3007.
  12. Canitrot, Y., Laurent, G., Astarie-Dequeker, C., Bordier, C., Cazaux, C. and Hoffmann, J. S. (2006). Enhanced expression and activity of DNA polymerase beta in chronic myelogenous leukemia. Anticancer Res 26(1B): 523-525.
  13. Boudsocq, F., Benaim, P., Canitrot, Y., Knibiehler, M., Ausseil, F., Capp, J. P., Bieth, A., Long, C., David, B., Shevelev, I., Frierich-Heinecken, E., Hubscher, U., Amalric, F., Massiot, G., Hoffmann, J. S. and Cazaux, C. (2005). Modulation of cellular response to cisplatin by a novel inhibitor of DNA polymerase beta. Mol Pharmacol 67(5): 1485-1492.
Protocols by Yvan Canitrot
  1. Homologous Recombination Assay
  2. Neutral Comet Assay