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Jonathan Schneck


M.D., Ph.D. in Pediatrics, Immunology at the Albert Einstein College of Medicine, Bronx, NY1983.

Current position

Professor of Pathology, Medicine and Oncology at Johns Hopkins University School of Medicine, Baltimore, MD USA.
Member of the Institute of Cellular Engineering, JHU

Publications (since 2005)

  1. Perica, K., Bieler, J. G., Edidin, M. and Schneck, J. (2012). Modulation of MHC binding by lateral association of TCR and coreceptor. Biophys J 103(9): 1890-1898.
  2. Webb, T. J., Li, X., Giuntoli, R. L., 2nd, Lopez, P. H., Heuser, C., Schnaar, R. L., Tsuji, M., Kurts, C., Oelke, M. and Schneck, J. P. (2012). Molecular identification of GD3 as a suppressor of the innate immune response in ovarian cancer. Cancer Res 72(15): 3744-3752.
  3. Boyle, S., Kolin, D. L., Bieler, J. G., Schneck, J. P., Wiseman, P. W. and Edidin, M. (2011). Quantum dot fluorescence characterizes the nanoscale organization of T cell receptors for antigen. Biophys J 101(11): L57-59.
  4. Lee, J. B., Oelke, M., Ramachandra, L., Canaday, D. H. and Schneck, J. P. (2011). Decline of influenza-specific CD8+ T cell repertoire in healthy geriatric donors. Immun Ageing 8: 6.
  5. Xiao, Z., Mohamood, A. S., Uddin, S., Gutfreund, R., Nakata, C., Marshall, A., Kimura, H., Caturegli, P., Womer, K. L., Huang, Y., Jie, C., Chakravarti, S., Schneck, J. P., Yagita, H. and Hamad, A. R. (2011). Inhibition of Fas ligand in NOD mice unmasks a protective role for IL-10 against insulitis development. Am J Pathol 179(2): 725-732.
  6. Chiu, Y. L., Schneck, J. P. and Oelke, M. (2011). HLA-Ig based artificial antigen presenting cells for efficient ex vivo expansion of human CTL. J Vis Exp(50).
  7. Li, Y., Tao, S. C., Zhu, H. and Schneck, J. P. (2011). High-throughput lectin microarray-based analysis of live cell surface glycosylation. Curr Protoc Protein Sci Chapter 12: Unit12 19.
  8. Yue, C., Oelke, M., Paulaitis, M. E. and Schneck, J. P. (2010). Novel cellular microarray assay for profiling T-cell peptide antigen specificities. J Proteome Res 9(11): 5629-5637.
  9. Schutz, C., Oelke, M., Schneck, J. P., Mackensen, A. and Fleck, M. (2010). Killer artificial antigen-presenting cells: the synthetic embodiment of a 'guided missile'. Immunotherapy 2(4): 539-550.
  10. Oelke, M. and Schneck, J. P. (2010). Overview of a HLA-Ig based "Lego-like system" for T cell monitoring, modulation and expansion. Immunol Res 47(1-3): 248-256.
  11. Ndhlovu, Z. M., Oelke, M., Schneck, J. P. and Griffin, D. E. (2010). Dynamic regulation of functionally distinct virus-specific T cells. Proc Natl Acad Sci U S A 107(8): 3669-3674.
  12. Ugel, S., Zoso, A., De Santo, C., Li, Y., Marigo, I., Zanovello, P., Scarselli, E., Cipriani, B., Oelke, M., Schneck, J. P. and Bronte, V. (2009). In vivo administration of artificial antigen-presenting cells activates low-avidity T cells for treatment of cancer. Cancer Res 69(24): 9376-9384.
  13. Mertens, J., Fabri, M., Zingarelli, A., Kubacki, T., Meemboor, S., Groneck, L., Seeger, J., Bessler, M., Hafke, H., Odenthal, M., Bieler, J. G., Kalka, C., Schneck, J. P., Kashkar, H. and Kalka-Moll, W. M. (2009). Streptococcus pneumoniae serotype 1 capsular polysaccharide induces CD8CD28 regulatory T lymphocytes by TCR crosslinking. PLoS Pathog 5(9): e1000596.
  14. Ndhlovu, Z. M., Angenendt, M., Heckel, D., Schneck, J. P., Griffin, D. E. and Oelke, M. (2009). Development of an artificial-antigen-presenting-cell-based assay for the detection of low-frequency virus-specific CD8(+) T cells in whole blood, with application for measles virus. Clin Vaccine Immunol 16(7): 1066-1073.
  15. Webb, T. J., Bieler, J. G., Schneck, J. P. and Oelke, M. (2009). Ex vivo induction and expansion of natural killer T cells by CD1d1-Ig coated artificial antigen presenting cells. J Immunol Methods 346(1-2): 38-44.
  16. Durai, M., Krueger, C., Ye, Z., Cheng, L., Mackensen, A., Oelke, M. and Schneck, J. P. (2009). In vivo functional efficacy of tumor-specific T cells expanded using HLA-Ig based artificial antigen presenting cells (aAPC). Cancer Immunol Immunother 58(2): 209-220.
  17. Webb, T. J., Giuntoli, R. L., 2nd, Rogers, O., Schneck, J. and Oelke, M. (2008). Ascites specific inhibition of CD1d-mediated activation of natural killer T cells. Clin Cancer Res 14(23): 7652-7658.
  18. Mohamood, A. S., Bargatze, D., Xiao, Z., Jie, C., Yagita, H., Ruben, D., Watson, J., Chakravarti, S., Schneck, J. P. and Hamad, A. R. (2008). Fas-mediated apoptosis regulates the composition of peripheral alphabeta T cell repertoire by constitutively purging out double negative T cells. PLoS ONE 3(10): e3465.
  19. Shaikh, S. R., Mitchell, D., Carroll, E., Li, M., Schneck, J. and Edidin, M. (2008). Differential effects of a saturated and a monounsaturated fatty acid on MHC class I antigen presentation. Scand J Immunol 68(1): 30-42.
  20. Schutz, C., Fleck, M., Mackensen, A., Zoso, A., Halbritter, D., Schneck, J. P. and Oelke, M. (2008). Killer artificial antigen-presenting cells: a novel strategy to delete specific T cells. Blood 111(7): 3546-3552.
  21. Nagaraj, S., Gupta, K., Pisarev, V., Kinarsky, L., Sherman, S., Kang, L., Herber, D. L., Schneck, J. and Gabrilovich, D. I. (2007). Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer. Nat Med 13(7): 828-835.
  22. Mohamood, A. S., Guler, M. L., Xiao, Z., Zheng, D., Hess, A., Wang, Y., Yagita, H., Schneck, J. P. and Hamad, A. R. (2007). Protection from autoimmune diabetes and T-cell lymphoproliferation induced by FasL mutation are differentially regulated and can be uncoupled pharmacologically. Am J Pathol 171(1): 97-106.
  23. Fahmy, T. M., Schneck, J. P. and Saltzman, W. M. (2007). A nanoscopic multivalent antigen-presenting carrier for sensitive detection and drug delivery to T cells. Nanomedicine 3(1): 75-85.
  24. Deviren, G., Gupta, K., Paulaitis, M. E. and Schneck, J. P. (2007). Detection of antigen-specific T cells on p/MHC microarrays. J Mol Recognit 20(1): 32-38.
  25. Mohamood, A. S., Trujillo, C. J., Zheng, D., Jie, C., Murillo, F. M., Schneck, J. P. and Hamad, A. R. (2006). Gld mutation of Fas ligand increases the frequency and up-regulates cell survival genes in CD25+CD4+ TR cells. Int Immunol 18(8): 1265-1277.
  26. Boin, F., Wigley, F. M., Schneck, J. P., Oelke, M. and Rosen, A. (2005). Evaluation of topoisomerase-1-specific CD8+ T-cell response in systemic sclerosis. Ann N Y Acad Sci 1062: 137-145.
  27. Oelke, M., Krueger, C., Giuntoli, R. L., 2nd and Schneck, J. P. (2005). Artificial antigen-presenting cells: artificial solutions for real diseases. Trends Mol Med 11(9): 412-420.
  28. Karabekian, Z., Lytton, S. D., Silver, P. B., Sergeev, Y. V., Schneck, J. P. and Caspi, R. R. (2005). Antigen/MHC class II/Ig dimers for study of uveitogenic T cells: IRBP p161-180 presented by both IA and IE molecules. Invest Ophthalmol Vis Sci 46(10): 3769-3776.
  29. Oelke, M., Krueger, C. and Schneck, J. P. (2005). Technological advances in adoptive immunotherapy. Drugs Today (Barc) 41(1): 13-21.
Protocols by Jonathan Schneck
  1. Generation of Human iNKT Cell Lines
  2. Generation of Mouse iNKT Cell Lines