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Xiangming Li


Ph.D. in Immunology, University of Science and Technology of China 2006.

Current position

Research Scientist at The Rockefeller University, Aaron Diamond AIDS Research Center, New York, NY USA.


  1. Huang, J., Li, X., Kohno, K., Hatano, M., Tokuhisa, T., Murray, P. J., Brocker, T. and Tsuji, M. (2013). Generation of tissue-specific H-2Kd transgenic mice for the study of K(d)-restricted malaria epitope-specific CD8+ T-cell responses in vivo. J Immunol Methods 387(1-2): 254-261.
  2. Li, X., Polacino, P., Garcia-Navarro, R., Hu, S. L. and Tsuji, M. (2012). Peripheral blood invariant natural killer T cells of pig-tailed macaques. PLoS ONE 7(10): e48166.
  3. Avci, F. Y.*, Li, X.*, Tsuji, M. and Kasper, D. L. (2012). Isolation of carbohydrate-specific CD4(+) T cell clones from mice after stimulation by two model glycoconjugate vaccines. Nat Protoc 7(12): 2180-2192. *Co-first author
  4. Webb, T. J., Li, X., Giuntoli, R. L., 2nd, Lopez, P. H., Heuser, C., Schnaar, R. L., Tsuji, M., Kurts, C., Oelke, M. and Schneck, J. P. (2012). Molecular identification of GD3 as a suppressor of the innate immune response in ovarian cancer. Cancer Res 72(15): 3744-3752.
  5. Rai, U., Huang, J., Mishra, S., Li, X., Shiratsuchi, T. and Tsuji, M. (2012). A New Method to Determine Antigen-Specific CD8+ T Cell Activity in Vivo by Hydrodynamic Injection. Biomolecules 2(1): 23-33.
  6. Mishra, S., Rai, U., Shiratsuchi, T., Li, X., Vanloubbeeck, Y., Cohen, J., Nussenzweig, R. S., Winzeler, E. A., Tsuji, M. and Nussenzweig, V. (2011). Identification of non-CSP antigens bearing CD8 epitopes in mice immunized with irradiated sporozoites. Vaccine 29(43): 7335-7342.
  7. Avci, F. Y., Li, X., Tsuji, M. and Kasper, D. L. (2011). A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design. Nat Med 17(12): 1602-1609.
  8. Kinjo, Y., Illarionov, P., Vela, J. L., Pei, B., Girardi, E., Li, X., Li, Y., Imamura, M., Kaneko, Y., Okawara, A., Miyazaki, Y., Gomez-Velasco, A., Rogers, P., Dahesh, S., Uchiyama, S., Khurana, A., Kawahara, K., Yesilkaya, H., Andrew, P. W., Wong, C. H., Kawakami, K., Nizet, V., Besra, G. S., Tsuji, M., Zajonc, D. M. and Kronenberg, M. (2011). Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria. Nat Immunol 12(10): 966-974.
  9. Padte, N. N., Li, X., Tsuji, M. and Vasan, S. (2011). Clinical development of a novel CD1d-binding NKT cell ligand as a vaccine adjuvant. Clin Immunol 140(2): 142-151.
  10. Renukaradhya, G. J., Manickam, C., Khatri, M., Rauf, A., Li, X., Tsuji, M., Rajashekara, G. and Dwivedi, V. (2011). Functional invariant NKT cells in pig lungs regulate the airway hyperreactivity: a potential animal model. J Clin Immunol 31(2): 228-239.
  11. Li, X., Fujio, M., Imamura, M., Wu, D., Vasan, S., Wong, C. H., Ho, D. D. and Tsuji, M. (2010). Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant. Proc Natl Acad Sci U S A 107(29): 13010-13015.
  12. Lombardi, V., Stock, P., Singh, A. K., Kerzerho, J., Yang, W., Sullivan, B. A., Li, X., Shiratsuchi, T., Hnatiuk, N. E., Howell, A. R., Yu, K. O., Porcelli, S. A., Tsuji, M., Kronenberg, M., Wilson, S. B. and Akbari, O. (2010). A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity. J Immunol 184(4): 2107-2115.
  13. Horowitz, A., Li, X., Poles, M. A. and Tsuji, M. (2009). Use of immobilized HLA-A2:Ig dimeric proteins to determine the level of epitope-specific, HLA-restricted CD8(+) T-cell response. Scand J Immunol 70(5): 415-422.
  14. Li, X., Shiratsuchi, T., Chen, G., Dellabona, P., Casorati, G., Franck, R. W. and Tsuji, M. (2009). Invariant TCR rather than CD1d shapes the preferential activities of C-glycoside analogues against human versus murine invariant NKT cells. J Immunol 183(7): 4415-4421.
  15. Li, X., Chen, G., Garcia-Navarro, R., Franck, R. W. and Tsuji, M. (2009). Identification of C-glycoside analogues that display a potent biological activity against murine and human invariant natural killer T cells. Immunology 127(2): 216-225.
  16. Liang, P. H., Imamura, M., Li, X., Wu, D., Fujio, M., Guy, R. T., Wu, B. C., Tsuji, M. and Wong, C. H. (2008). Quantitative microarray analysis of intact glycolipid-CD1d interaction and correlation with cell-based cytokine production. J Am Chem Soc 130(37): 12348-12354.
  17. Huang, Y., Chen, A., Li, X., Chen, Z., Zhang, W., Song, Y., Gurner, D., Gardiner, D., Basu, S., Ho, D. D. and Tsuji, M. (2008). Enhancement of HIV DNA vaccine immunogenicity by the NKT cell ligand, alpha-galactosylceramide. Vaccine 26(15): 1807-1816.
  18. Li, X., Yang, X., Li, L., Liu, H. and Liu, J. (2006). A truncated C-terminal fragment of Mycobacterium tuberculosis HSP70 gene enhanced potency of HBV DNA vaccine. Vaccine 24(16): 3321-3331.
  19. Li, X., Yang, X., Jiang, Y. and Liu, J. (2005). A novel HBV DNA vaccine based on T cell epitopes and its potential therapeutic effect in HBV transgenic mice. Int Immunol 17(10): 1293-1302.
  20. Li, W. F., Chen, L., Li, X. M. and Liu, J. (2005). A C-type lectin-like protein from Agkistrodon acutus venom binds to both platelet glycoprotein Ib and coagulation factor IX/factor X. Biochem Biophys Res Commun 332(3): 904-912.
  21. Cheng, X., Xu, Z. Y., Liu, Q. D., Li, X. M., Li, X. Y. and Liu, J. (2000). Purification and Characterization of a Platelet Agglutinating Inhibiting Protein (Agkisacutacin) from Agkistrodon acutus Venom. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 32(6): 653-656.
Protocols by Xiangming Li
  1. Generation of Human iNKT Cell Lines
  2. Generation of Mouse iNKT Cell Lines