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Igor V. Sharakhov

Education

Ph.D. in Genetics, Institute of Cytology and Genetics, Novosibirsk, Russia, 1996

Current position

Affiliate Faculty Member, Public Health Program, Virginia Tech, VA

Associate Professor, Department of Entomology, Virginia Tech, VA

Affiliate Faculty Member, Fralin Life Science Institute, Virginia Tech, VA

Affiliate Faculty Member, Genetics, Bioinformatics, and Computational Biology (GBCB) Program, Virginia Tech, VA

Publications (since 2005)

Selected papers in refereed journals

  1. Sharakhova, M. V., Peery, A., Antonio-Nkondjio, C., Xia, A., Ndo, C., Awono-Ambene, P., Simard, F. and Sharakhov, I. V. (2013). Cytogenetic analysis of Anopheles ovengensis revealed high structural divergence of chromosomes in the Anopheles nili group. Infect Genet Evol 16: 341-348.
  2. Kamali, M., Xia, A., Tu, Z. and Sharakhov, I. V. (2012). A new chromosomal phylogeny supports the repeated origin of vectorial capacity in malaria mosquitoes of the Anopheles gambiae complex. PLoS Pathog 8(10): e1002960.
  3. Timoshevskiy, V. A., Sharma, A., Sharakhov, I. V. and Sharakhova, M. V. (2012). Fluorescent in situ hybridization on mitotic chromosomes of mosquitoes. J Vis Exp(67): e4215. Web site: http://www.jove.com/video/4215?status=a6221k
  4. Bridi, L. C., Sharakhova, M. V., Sharakhov, I. V., Cordeiro, J., Azevedo Junior, G. M., Tadei, W. P. and Rafael, M. S. (2013). Chromosomal localization of actin genes in the malaria mosquito Anopheles darlingi. Med Vet Entomol 27(1): 118-121.
  5. George, P.*, Sharakhova, M. V. and Sharakhov, I. V. (2012). High-throughput physical mapping of chromosomes using automated in situ hybridization. J Vis Exp(64). Web site: http://www.jove.com/details.php?id=4007&status=a6013k
  6. Peery, A.”, Sharakhova, M. V., Antonio-Nkondjio, C., Ndo, C., Weill, M., Simard, F. and Sharakhov, I. V. (2011). Improving the population genetics toolbox for the study of the African malaria vector Anopheles nili: microsatellite mapping to chromosomes. Parasit Vectors 4: 202.
  7. Mancini, E., Baldini, F., Tammaro, F., Calzetta, M., Serrao, A., George, P., Morlais, I., Masiga, D., Sharakhov, I. V., Rogers, D. W., Catteruccia, F. and della Torre, A. (2011). Molecular characterization and evolution of a gene family encoding male-specific reproductive proteins in the African malaria vector Anopheles gambiae. BMC Evol Biol 11: 292.
  8. Sharakhova, M. V., Timoshevskiy, V. A., Yang, F.*, Demin, S., Severson, D. W. and Sharakhov, I. V. (2011). Imaginal discs--a new source of chromosomes for genome mapping of the yellow fever mosquito Aedes aegypti. PLoS Negl Trop Dis 5(10): e1335.
  9. Kamali, M.*, Sharakhova, M. V., Baricheva, E., Karagodin, D., Tu, Z. and Sharakhov, I. V. (2011). An integrated chromosome map of microsatellite markers and inversion breakpoints for an Asian malaria mosquito, Anopheles stephensi. J Hered 102(6): 719-726.
  10. Sharakhova, M. V., Xia, A., Leman, S. C. and Sharakhov, I. V. (2011). Arm-specific dynamics of chromosome evolution in malaria mosquitoes. BMC Evol Biol 11: 91.
  11. Mancini, E., Tammaro, F., Baldini, F., Via, A., Raimondo, D., George, P., Audisio, P., Sharakhov, I. V., Tramontano, A., Catteruccia, F. and della Torre, A. (2011). Molecular evolution of a gene cluster of serine proteases expressed in the Anopheles gambiae female reproductive tract. BMC Evol Biol 11: 72.
  12. Sharakhova, M. V., Antonio-Nkondjio, C., Xia, A.*, Ndo, C., Awono-Ambene, P., Simard, F. and Sharakhov, I. V. (2011). Cytogenetic map for Anopheles nili: application for population genetics and comparative physical mapping. Infect Genet Evol 11(4): 746-754.
  13. Diao, Y., Qi, Y., Ma, Y., Xia, A.*, Sharakhov, I., Chen, X., Biedler, J., Ling, E. and Tu, Z. J. (2011). Next-generation sequencing reveals recent horizontal transfer of a DNA transposon between divergent mosquitoes. PloS one 6(2): e16743.
  14. Tubio, J. M., Tojo, M., Bassaganyas, L., Escaramis, G., Sharakhov, I. V., Sharakhova, M. V., Tornador, C., Unger, M. F., Naveira, H., Costas, J. and Besansky, N. J. (2011). Evolutionary dynamics of the Ty3/gypsy LTR retrotransposons in the genome of Anopheles gambiae. PLoS One 6(1): e16328.
  15. Sharakhova, M. V., Xia, A.*, Tu, Z., Shouche, Y. S., Unger, M. F. and Sharakhov, I. V. (2010). A physical map for an Asian malaria mosquito, Anopheles stephensi. Am J Trop Med Hyg 83(5): 1023-1027.
  16. Sharakhova, M. V., George, P.*, Brusentsova, I. V., Leman, S. C., Bailey, J. A., Smith, C. D. and Sharakhov, I. V. (2010). Genome mapping and characterization of the Anopheles gambiae heterochromatin. BMC Genomics 11: 459.
  17. George, P.*, Sharakhova, M. V. and Sharakhov, I. V. (2010). High-resolution cytogenetic map for the African malaria vector Anopheles gambiae. Insect Mol Biol 19(5): 675-682.
  18. Xia, A.*, Sharakhova, M. V., Leman, S. C., Tu, Z., Bailey, J. A., Smith, C. D. and Sharakhov, I. V. (2010). Genome landscape and evolutionary plasticity of chromosomes in malaria mosquitoes. PLoS One 5(5): e10592.
  19. Serazin, A. C., Dana, A. N., Hillenmeyer, M. E., Lobo, N. F., Coulibaly, M. B., Willard, M. B., Harker, B. W., Sharakhov, I. V., Collins, F. H., Ribeiro, J. M. and Besansky, N. J. (2009). Comparative analysis of the global transcriptome of Anopheles funestus from Mali, West Africa. PLoS One 4(11): e7976.
  20. Grushko, O. G., Sharakhova, M. V., Stegnii, V. N. and Sharakhov, I. V. (2009). Molecular organization of heterochromatin in malaria mosquitoes of the Anopheles maculipennis subgroup. Gene 448(2): 192-197.
  21. Xia, A.*, Sharakhova, M. V. and Sharakhov, I. V. (2008). Reconstructing ancestral autosomal arrangements in the Anopheles gambiae complex. J Comput Biol 15(8): 965-980.
  22. Scali, C., Nolan, T., Sharakhov, I., Sharakhova, M., Crisanti, A. and Catteruccia, F. (2007). Post-integration behavior of a Minos transposon in the malaria mosquito Anopheles stephensi. Mol Genet Genomics 278(5): 575-584.
  23. Riehle, M. M., Markianos, K., Lambrechts, L., Xia, A.*, Sharakhov, I., Koella, J. C. and Vernick, K. D. (2007). A major genetic locus controlling natural Plasmodium falciparum infection is shared by East and West African Anopheles gambiae. Malar J 6: 87.
  24. White, B. J., Santolamazza, F., Kamau, L., Pombi, M., Grushko, O., Mouline, K., Brengues, C., Guelbeogo, W., Coulibaly, M., Kayondo, J. K., Sharakhov, I., Simard, F., Petrarca, V., Della Torre, A. and Besansky, N. J. (2007). Molecular karyotyping of the 2La inversion in Anopheles gambiae. Am J Trop Med Hyg 76(2): 334-339.
  25. Sharakhova, M. V., Xia, A.*, McAlister, S. I.” and Sharakhov, I. V. (2006). A standard cytogenetic photomap for the mosquito Anopheles stephensi (Diptera: Culicidae): application for physical mapping. J Med Entomol 43(5): 861-866.
  26. Sharakhov, I. V., White, B. J., Sharakhova, M. V., Kayondo, J., Lobo, N. F., Santolamazza, F., Della Torre, A., Simard, F., Collins, F. H. and Besansky, N. J. (2006). Breakpoint structure reveals the unique origin of an interspecific chromosomal inversion (2La) in the Anopheles gambiae complex. Proc Natl Acad Sci U S A 103(16): 6258-6262.
  27. Grushko, O. G., Rusakova, A. M., Sharakhova, M. V., Sharakhov, I. V. and Stegnii, V. N. (2006). Localization of repetitive DNA sequences in the pericentromeric heterochromatin of malarial mosquitoes of the "Anopheles maculipennis" complex. Tsitologiia 48(3): 240-245.
  28. Boikova, T. V., Sharakhov, I. V., Kopyl, S. A., Volkova, E., Fisher, P. A., Rogachev, V. A., Sebeleva, T. E. and Bogachev, S. S. (2005). A combined approach to mapping the proximal border of the right arm of polytene chromosome 2 in Drosophila melanogaster otu 11. Tsitologiia 47(3): 249-254.
  29. Sharakhov, I. V., Baricheva, E. M., Bogachev, S. S., Fisher, P. A., Lapik, E. R., Rogachev, V. A. and Sebeleva, T. E. (2005). Specific DNA sequences are associated with nuclear envelopes of pseudonurse cells in Drosophila melanogaster otu 11. Tsitologiia 47(3): 243-248.

    (* indicate graduate students, ” indicate undergraduate students)

Reviews

  1. Sharakhov, I. V. and Sharakhova, M. V. (2010). Chromosome evolution in malaria mosquitoes. Genetika 46(9): 1250-1253.
  2. Sharakhova, M. V. and Sharakhov, I. V. (2010). Organization and evolution of heterochromatin in malaria mosquitoes. Genetika 46(10): 1417-1420.

Peer-reviewed Books and Chapters

  1. Sharakhov, I. V. 2013. Chromosome plasticity, adaptation and speciation in malaria mosquitoes. In P. Michalak [ed.], Speciation: Natural Processes, Genetics and Biodiversity. Nova Science Publishers, Inc., New York (invited book chapter).
  2. Sharakhov, I. V., and M. V. Sharakhova. 2008. Cytogenetic and physical mapping of mosquito genomes. In J. F. Verrity and L. E. Abbington [eds.], Chromosome mapping research developments. Nova Science Publishers, Inc., New York (invited book chapter).
Protocols by Igor V. Sharakhov
  1. Fluorescence in situ Hybridization to the Polytene Chromosomes of Anopheles Mosquitoes