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Tammy Regena Ozment

Education

Ph.D. in Biomedical Science, East Tennessee State University, Johnson City, Tennessee, 2006

DVM, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, 1998

Current position

Research Assistant Professor, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee

Publications

  1. Ozment, T. R., Ha, T., Breuel, K. F., Ford, T. R., Ferguson, D. A., Kalbfleisch, J., Schweitzer, J. B., Kelley, J. L., Li, C. and Williams, D. L. (2012). Scavenger receptor class a plays a central role in mediating mortality and the development of the pro-inflammatory phenotype in polymicrobial sepsis. PLoS Pathog 8(10): e1002967.
  2. Ozment, T. R., Goldman, M. P., Kalbfleisch, J. H. and Williams, D. L. (2012). Soluble glucan is internalized and trafficked to the Golgi apparatus in macrophages via a clathrin-mediated, lipid raft-regulated mechanism. J Pharmacol Exp Ther 342(3): 808-815.
  3. Ozment-Skelton, T. R., deFluiter, E. A., Ha, T., Li, C., Graves, B. M., Ferguson, D. A., Jr., Schweitzer, J. B., Preizsner, J., Brown, G. D., Gordon, S., Kalbfleisch, J. H. and Williams, D. L. (2009). Leukocyte Dectin-1 expression is differentially regulated in fungal versus polymicrobial sepsis. Crit Care Med 37(3): 1038-1045.
  4. Ozment-Skelton, T. R., Goldman, M. P., Gordon, S., Brown, G. D. and Williams, D. L. (2006). Prolonged reduction of leukocyte membrane-associated Dectin-1 levels following beta-glucan administration. J Pharmacol Exp Ther 318(2): 540-546.
  5. Li, C., Hua, F., Ha, T., Singh, K., Lu, C., Kalbfleisch, J., Breuel, K. F., Ford, T., Kao, R. L., Gao, M., Ozment, T. R. and Williams, D. L. (2012). Activation of myocardial phosphoinositide-3-kinase p110alpha ameliorates cardiac dysfunction and improves survival in polymicrobial sepsis. PLoS One 7(9): e44712.
  6. Wondergem, R., Graves, B. M., Ozment-Skelton, T. R., Li, C. and Williams, D. L. (2010). Lipopolysaccharides directly decrease Ca2+ oscillations and the hyperpolarization-activated nonselective cation current If in immortalized HL-1 cardiomyocytes. Am J Physiol Cell Physiol 299(3): C665-671.
  7. Shah, V. B., Ozment-Skelton, T. R., Williams, D. L. and Keshvara, L. (2009). Vav1 and PI3K are required for phagocytosis of beta-glucan and subsequent superoxide generation by microglia. Mol Immunol 46(8-9): 1845-1853.
  8. Shah, V. B., Huang, Y., Keshwara, R., Ozment-Skelton, T., Williams, D. L. and Keshvara, L. (2008). Beta-glucan activates microglia without inducing cytokine production in Dectin-1-dependent manner. J Immunol 180(5): 2777-2785.
  9. Williams, D. L., Ozment-Skelton, T. and Li, C. (2006). Modulation of the phosphoinositide 3-kinase signaling pathway alters host response to sepsis, inflammation, and ischemia/reperfusion injury. Shock 25(5): 432-439.
  10. Fan, W., Ha, T., Li, Y., Ozment-Skelton, T., Williams, D. L., Kelley, J., Browder, I. W. and Li, C. (2005). Overexpression of TLR2 and TLR4 susceptibility to serum deprivation-induced apoptosis in CHO cells. Biochem Biophys Res Commun 337(3): 840-848.
  11. Rice, P. J., Adams, E. L., Ozment-Skelton, T., Gonzalez, A. J., Goldman, M. P., Lockhart, B. E., Barker, L. A., Breuel, K. F., Deponti, W. K., Kalbfleisch, J. H., Ensley, H. E., Brown, G. D., Gordon, S. and Williams, D. L. (2005). Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge. J Pharmacol Exp Ther 314(3): 1079-1086.
  12. Williams, D. L., Li, C., Ha, T., Ozment-Skelton, T., Kalbfleisch, J. H., Preiszner, J., Brooks, L., Breuel, K. and Schweitzer, J. B. (2004). Modulation of the phosphoinositide 3-kinase pathway alters innate resistance to polymicrobial sepsis. J Immunol 172(1): 449-456.
Protocols by Tammy Regena Ozment
  1. Pulmonary Myeloperoxidase Activity