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Deborah E. Sullivan


Ph.D. in Molecular and Cellular Biology, Tulane University, 1999

Current position

Associate Professor, Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA

Publications (since 2005)

  1. Bonvillain, R.W., Scarritt, M.E., Pashos, N.C., Mayeux, J.P., Meshberger, C.L., Betancourt, A.M., Sullivan, D.E. and Bunnell, B.A. (2013). Non-human Primate Lung Decellularization and Recellularization Using a Specialized Large-organ Bioreactor. JoVE. (in press).
  2. Zhang, S., Danchuk, S. D., Imhof, K. M., Semon, J. A., Scruggs, B. A., Bonvillain, R. W., Strong, A. L., Gimble, J. M., Betancourt, A. M., Sullivan, D. E. and Bunnell, B. A. (2013). Comparison of the therapeutic effects of human and mouse adipose-derived stem cells in a murine model of lipopolysaccharide-induced acute lung injury. Stem Cell Res Ther 4(1): 13.
  3. Strong, M. J., Xu, G., Coco, J., Baribault, C., Vinay, D. S., Lacey, M. R., Strong, A. L., Lehman, T. A., Seddon, M. B., Lin, Z., Concha, M., Baddoo, M., Ferris, M., Swan, K. F., Sullivan, D. E., Burow, M. E., Taylor, C. M. and Flemington, E. K. (2013). Differences in gastric carcinoma microenvironment stratify according to EBV infection intensity: implications for possible immune adjuvant therapy. PLoS Pathog 9(5): e1003341.
  4. Abboud, E. R., Shelby, B. D., Angelova, M., Nelson, A. B., Ferris, M., McFerrin, H. E., Morris, C. A. and Sullivan, D. E. (2013). Kaposi sarcoma-associated herpesvirus g protein-coupled receptor enhances endothelial cell survival in part by upregulation of bcl-2. Ochsner J 13(1): 66-75.
  5. Warner, J. A., Zwezdaryk, K. J., Day, B., Sullivan, D. E., Pridjian, G. and Morris, C. A. (2012). Human cytomegalovirus infection inhibits CXCL12- mediated migration and invasion of human extravillous cytotrophoblasts. Virol J 9(1): 255.
  6. Li, C., Nguyen, H. T., Zhuang, Y., Lin, Z., Flemington, E. K., Zhuo, Y., Kantrow, S. P., Morris, G. F., Sullivan, D. E. and Shan, B. (2012). Comparative profiling of miRNA expression of lung adenocarcinoma cells in two-dimensional and three-dimensional cultures. Gene 511(2): 143-150.
  7. Angelova, M., Zwezdaryk, K., Ferris, M., Shan, B., Morris, C. A. and Sullivan, D. E. (2012). Human cytomegalovirus infection dysregulates the canonical Wnt/beta-catenin signaling pathway. PLoS Pathog 8(10): e1002959.
  8. Bonvillain, R. W., Danchuk, S., Sullivan, D. E., Betancourt, A. M., Semon, J. A., Eagle, M. E., Mayeux, J. P., Gregory, A. N., Wang, G., Townley, I. K., Borg, Z. D., Weiss, D. J. and Bunnell, B. A. (2012). A nonhuman primate model of lung regeneration: detergent-mediated decellularization and initial in vitro recellularization with mesenchymal stem cells. Tissue Eng Part A 18(23-24): 2437-2452.
  9. Sullivan, D., Bonvillain, R., Zhang, S., Eagle, M. and Danchuk, S. (2011). Battling Inflammation in Acute Lung Injury and Acute Respiratory Distress Syndrome: Stem Cell-Based Therapy Targeting the Root Cause of Acute Lung Injury. J Pulmonar Respirat Med S 2: 2.
  10. Saito, S., Lasky, J. A., Guo, W., Nguyen, H., Mai, A., Danchuk, S., Sullivan, D. E. and Shan, B. (2011). Pharmacological inhibition of HDAC6 attenuates endothelial barrier dysfunction induced by thrombin. Biochem Biophys Res Commun 408(4): 630-634.
  11. Danchuk, S., Ylostalo, J. H., Hossain, F., Sorge, R., Ramsey, A., Bonvillain, R. W., Lasky, J. A., Bunnell, B. A., Welsh, D. A., Prockop, D. J. and Sullivan, D. E. (2011). Human multipotent stromal cells attenuate lipopolysaccharide-induced acute lung injury in mice via secretion of tumor necrosis factor-alpha-induced protein 6. Stem Cell Res Ther 2(3): 27.
  12. Li, C., Nguyen, H. T., Zhuang, Y., Lin, Y., Flemington, E. K., Guo, W., Guenther, J., Burow, M. E., Morris, G. F. and Sullivan, D. (2011). Post‐transcriptional up‐regulation of miR‐21 by type I collagen. Molecular Carcinogenesis 50(7): 563-570.
  13. Bunnell, B. A., Betancourt, A. M. and Sullivan, D. E. (2010). New concepts on the immune modulation mediated by mesenchymal stem cells. Stem Cell Res Ther 1(5): 34.
  14. Guenther, J. F., Cameron, J. E., Nguyen, H. T., Wang, Y., Sullivan, D. E., Shan, B., Lasky, J. A., Flemington, E. K. and Morris, G. F. (2010). Modulation of lung inflammation by the Epstein-Barr virus protein Zta. Am J Physiol Lung Cell Mol Physiol 299(6): L771-784.
  15. Lai, T.-C., Pociask, D. A., Ferris, M., Nguyen, H. T., Miller III, C. A., Brody, A. and Sullivan, D. (2009). Small Interfering RNAs (siRNAs) Targeting TGF-β 1 mRNA Suppress Asbestos-Induced Expression of TGF-β 1 and CTGF in Fibroblasts. Journal of Environmental Pathology, Toxicology and Oncology 28(2) :109-119.
  16. Block, G. J., Ohkouchi, S., Fung, F., Frenkel, J., Gregory, C., Pochampally, R., DiMattia, G., Sullivan, D. E. and Prockop, D. J. (2009). Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1. Stem Cells 27(3): 670-681.
  17. Sullivan, D. E., Ferris, M., Nguyen, H., Abboud, E. and Brody, A. R. (2009). TNF-alpha induces TGF-beta1 expression in lung fibroblasts at the transcriptional level via AP-1 activation. J Cell Mol Med 13(8B): 1866-1876.
  18. Yue, X., Li, X., Nguyen, H. T., Chin, D. R., Sullivan, D. E. and Lasky, J. A. (2008). Transforming growth factor-beta1 induces heparan sulfate 6-O-endosulfatase 1 expression in vitro and in vivo. J Biol Chem 283(29): 20397-20407.
  19. Uddin, M. N., Horvat, D., Glaser, S. S., Danchuk, S., Mitchell, B. M., Sullivan, D. E., Morris, C. A. and Puschett, J. B. (2008). Marinobufagenin inhibits proliferation and migration of cytotrophoblast and CHO cells. Placenta 29(3): 266-273.
  20. Sullivan, D. E., Ferris, M., Pociask, D. and Brody, A. R. (2008). The latent form of TGFbeta(1) is induced by TNFalpha through an ERK specific pathway and is activated by asbestos-derived reactive oxygen species in vitro and in vivo. J Immunotoxicol 5(2): 145-149.
  21. Spees, J. L., Whitney, M. J., Sullivan, D. E., Lasky, J. A., Laboy, M., Ylostalo, J. and Prockop, D. J. (2008). Bone marrow progenitor cells contribute to repair and remodeling of the lung and heart in a rat model of progressive pulmonary hypertension. FASEB J 22(4): 1226-1236.
  22. Yin, Q., Brody, A. R. and Sullivan, D. E. (2007). Laser capture microdissection reveals dose-response of gene expression in situ consequent to asbestos exposure. Int J Exp Pathol 88(6): 415-425.
  23. Shelby, B. D., LaMarca, H. L., McFerrin, H. E., Nelson, A. B., Lasky, J. A., Sun, G., Myatt, L., Offermann, M. K., Morris, C. A. and Sullivan, D. E. (2007). Kaposi's sarcoma associated herpesvirus G-protein coupled receptor activation of cyclooxygenase-2 in vascular endothelial cells. Virol J 4(1): 87.
  24. Spees, J. L., Pociask, D. A., Sullivan, D. E., Whitney, M. J., Lasky, J. A., Prockop, D. J. and Brody, A. R. (2007). Engraftment of bone marrow progenitor cells in a rat model of asbestos-induced pulmonary fibrosis. Am J Respir Crit Care Med 176(4): 385-394.
  25. Abboud, E. R., Coffelt, S. B., Figueroa, Y. G., Zwezdaryk, K. J., Nelson, A. B., Sullivan, D. E., Morris, C. B., Tang, Y., Beckman, B. S. and Scandurro, A. B. (2007). Integrin-linked kinase: a hypoxia-induced anti-apoptotic factor exploited by cancer cells. Int J Oncol 30(1): 113-122.
  26. Sullivan, D. E. and Brody, A. R. (2006). The asbestos model of interstitial fibrosis. Donaldson K and Borm P, ed. Particle Toxicology. Boca Raton: Taylor & Francis. 227-244.
  27. Hazari, S., Patil, A., Joshi, V., Sullivan, D. E., Fermin, C. D., Garry, R. F., Elliott, R. M. and Dash, S. (2005). Alpha interferon inhibits translation mediated by the internal ribosome entry site of six different hepatitis C virus genotypes. J Gen Virol 86(Pt 11): 3047-3053.
  28. Sullivan, D. E., Ferris, M., Pociask, D. and Brody, A. R. (2005). Tumor Necrosis Factor-α Induces Transforming Growth Factor-β1 Expression in Lung Fibroblasts Through the Extracellular Signal–Regulated Kinase Pathway. American journal of respiratory cell and molecular biology 32(4): 342-349.
Protocols by Deborah E. Sullivan
  1. Extravillous Trophoblast Migration and Invasion Assay