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Paola Zacchi

Education

Ph.D in Biological Sciences, Department of Cell Biology at the  European Molecular Biology Laboratory, Heidelberg, Germany, 1998

Current Position

Research assistant, The International School for Advanced Studies, Department of Neurobiology, Trieste, Italy

Publications

  1. Antonelli, R., De Filippo, R., Middei, S., Stancheva, S., Pastore, B., Ammassari-Teule, M., Barberis, A., Cherubini, E. and Zacchi, P. (2016). Pin1 Modulates the Synaptic Content of NMDA Receptors via Prolyl-Isomerization of PSD-95. J Neurosci 36(20): 5437-5447.
  2. Antonelli, R., Pizzarelli, R., Pedroni, A., Fritschy, J. M., Del Sal, G., Cherubini, E. and Zacchi, P. (2014). Pin1-dependent signalling negatively affects GABAergic transmission by modulating neuroligin2/gephyrin interaction. Nat Commun 5: 5066.
  3. Zacchi, P., Antonelli, R. and Cherubini, E. (2014). Gephyrin phosphorylation in the functional organization and plasticity of GABAergic synapses. Front Cell Neurosci 8: 103.
  4. Cherubini, E. and Zacchi, P. (2012). Building up the inhibitory synapse. Front Cell Neurosci 6: 62.
  5. Varley, Z. K., Pizzarelli, R., Antonelli, R., Stancheva, S. H., Kneussel, M., Cherubini, E. and Zacchi, P. (2011). Gephyrin regulates GABAergic and glutamatergic synaptic transmission in hippocampal cell cultures. J Biol Chem 286(23): 20942-20951.
  6. Marchionni, I., Kasap, Z., Mozrzymas, J. W., Sieghart, W., Cherubini, E. and Zacchi, P. (2009). New insights on the role of gephyrin in regulating both phasic and tonic GABAergic inhibition in rat hippocampal neurons in culture. Neuroscience 164(2): 552-562.
  7. Safiulina, V. F., Zacchi, P., Taglialatela, M., Yaari, Y. and Cherubini, E. (2008). Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus. J Physiol 586(22): 5437-5453.
  8. Zacchi, P., Dreosti, E., Visintin, M., Moretto-Zita, M., Marchionni, I., Cannistraci, I., Kasap, Z., Betz, H., Cattaneo, A. and Cherubini, E. (2008). Gephyrin selective intrabodies as a new strategy for studying inhibitory receptor clustering. J Mol Neurosci 34(2): 141-148.
  9. Mohajerani, M. H., Sivakumaran, S., Zacchi, P., Aguilera, P. and Cherubini, E. (2007). Correlated network activity via BDNF and ERK pathway at immanute CA3-CA1 connections in the hippocampus. PNAS 104: 13176-13181.
  10. Zita, M. M., Marchionni, I., Bottos, E., Righi, M., Del Sal, G., Cherubini, E. and Zacchi, P. (2007). Post-phosphorylation prolyl isomerisation of gephyrin represents a mechanism to modulate glycine receptors function. EMBO J 26(7): 1761-1771.
  11. Petrini, E. M., Marchionni, I., Zacchi, P., Sieghart, W. and Cherubini, E. (2004). Clustering of extrasynaptic GABA(A) receptors modulates tonic inhibition in cultured hippocampal neurons. J Biol Chem 279(44): 45833-45843.
  12. Mantovani, F., Piazza, S., Gostissa, M., Strano, S., Zacchi, P., Mantovani, R., Blandino, G. and Del Sal, G. (2004). Pin1 links the activities of c-Abl and p300 in regulating p73 function. Mol Cell 14(5): 625-636.
  13. Zacchi, P., Sblattero, D., Florian, F., Marzari, R. and Bradbury, A. R. (2003). Selecting open reading frames from DNA. Genome Res 13(5): 980-990.
  14. Petrini, E. M., Zacchi, P., Barberis, A., Mozrzymas, J. W. and Cherubini, E. (2003). Declusterization of GABAA receptors affects the kinetic properties of GABAergic currents in cultured hippocampal neurons. J Biol Chem 278(18): 16271-16279.
  15. Zacchi, P., Gostissa, M., Uchida, T., Salvagno, C., Avolio, F., Volinia, S., Ronai, Z., Blandino, G., Schneider, C. and Del Sal, G. (2002). The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults. Nature 419(6909): 853-857.
  16. Fogal, V., Gostissa, M., Sandy, P., Zacchi, P., Sternsdorf, T., Jensen, K., Pandolfi, P. P., Will, H., Schneider, C. and Del Sal, G. (2000). Regulation of p53 activity in nuclear bodies by a specific PML isoform. EMBO J 19(22): 6185-6195.
  17. Zacchi, P., Stenmark, H., Parton, R. G., Orioli, D., Lim, F., Giner, A., Mellman, I., Zerial, M. and Murphy, C. (1998). Rab17 regulates membrane trafficking through apical recycling endosomes in polarized epithelial cells. J Cell Biol 140(5): 1039-1053.
  18. Murphy, C., Zacchi, P., Parton, R. G., Zerial, M. and Lim, F. (1997). HSV infection of polarized epithelial cells on filter supports: implications for transport assays and protein localization. Eur J Cell Biol 72(3): 278-281.
Protocols by Paola Zacchi
  1. MPM-2 Mediated Immunoprecipitation of Proteins Undergoing Proline-directed Phosphorylation