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Callie  S. Kwartler

Callie S. Kwartler


Ph.D. in Cell and Regulatory Biology, UTHSC-Houston Graduate School of Biomedical Sciences, Houston, TX, 2013

Current Position

Postdoctoral Researcher, University of Texas Health Science Center at Houston


  1. Kuang, S. Q., Medina-Martinez, O., Guo, D. C., Gong, L., Regalado, E. S., Reynolds, C. L., Boileau, C., Jondeau, G., Prakash, S. K., Kwartler, C. S., Zhu, L. Y., Peters, A. M., Duan, X. Y., Bamshad, M. J., Shendure, J., Nickerson, D. A., Santos-Cortez, R. L., Dong, X., Leal, S. M., Majesky, M. W., Swindell, E. C., Jamrich, M. and Milewicz, D. M. (2016). FOXE3 mutations predispose to thoracic aortic aneurysms and dissections. J Clin Invest 126(3): 948-961.
  2. Kwartler, C. S., Chen, J., Thakur, D., Li, S., Baskin, K., Wang, S., Wang, Z. V., Walker, L., Hill, J. A., Epstein, H. F., Taegtmeyer, H. and Milewicz, D. M. (2014). Overexpression of smooth muscle myosin heavy chain leads to activation of the unfolded protein response and autophagic turnover of thick filament-associated proteins in vascular smooth muscle cells. J Biol Chem 289(20): 14075-14088.
  3. Kuang, S. Q., Geng, L., Prakash, S. K., Cao, J. M., Guo, S., Villamizar, C., Kwartler, C. S., Peters, A. M., Brasier, A. R. and Milewicz, D. M. (2013). Aortic remodeling after transverse aortic constriction in mice is attenuated with AT1 receptor blockade. Arterioscler Thromb Vasc Biol 33(9): 2172-2179.
  4. Papke, C. L., Cao, J., Kwartler, C. S., Villamizar, C., Byanova, K. L., Lim, S. M., Sreenivasappa, H., Fischer, G., Pham, J., Rees, M., Wang, M., Chaponnier, C., Gabbiani, G., Khakoo, A. Y., Chandra, J., Trache, A., Zimmer, W. and Milewicz, D. M. (2013). Smooth muscle hyperplasia due to loss of smooth muscle alpha-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-beta. Hum Mol Genet 22(15): 3123-3137.
  5. Boileau, C., Guo, D. C., Hanna, N., Regalado, E. S., Detaint, D., Gong, L., Varret, M., Prakash, S. K., Li, A. H., d'Indy, H., Braverman, A. C., Grandchamp, B., Kwartler, C. S., Gouya, L., Santos-Cortez, R. L., Abifadel, M., Leal, S. M., Muti, C., Shendure, J., Gross, M. S., Rieder, M. J., Vahanian, A., Nickerson, D. A., Michel, J. B., National Heart, L., Blood Institute Go Exome Sequencing, P., Jondeau, G. and Milewicz, D. M. (2012). TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome. Nat Genet 44(8): 916-921.
  6. Kuang, S. Q., Kwartler, C. S., Byanova, K. L., Pham, J., Gong, L., Prakash, S. K., Huang, J., Kamm, K. E., Stull, J. T., Sweeney, H. L. and Milewicz, D. M. (2012). Rare, nonsynonymous variant in the smooth muscle-specific isoform of myosin heavy chain, MYH11, R247C, alters force generation in the aorta and phenotype of smooth muscle cells. Circ Res 110(11): 1411-1422.
  7. Hale, V. A., Guiney, E. L., Goldberg, L. Y., Haduong, J. H., Kwartler, C. S., Scangos, K. W. and Goutte, C. (2012). Notch signaling is antagonized by SAO-1, a novel GYF-domain protein that interacts with the E3 ubiquitin ligase SEL-10 in Caenorhabditis elegans. Genetics 190(3): 1043-1057.
  8. Kuang, S. Q., Guo, D. C., Prakash, S. K., McDonald, M. L., Johnson, R. J., Wang, M., Regalado, E. S., Russell, L., Cao, J. M., Kwartler, C., Fraivillig, K., Coselli, J. S., Safi, H. J., Estrera, A. L., Leal, S. M., LeMaire, S. A., Belmont, J. W., Milewicz, D. M. and Gen, T. A. C. I. (2011). Recurrent chromosome 16p13.1 duplications are a risk factor for aortic dissections. PLoS Genet 7(6): e1002118.
  9. Inamoto, S., Kwartler, C. S., Lafont, A. L., Liang, Y. Y., Fadulu, V. T., Duraisamy, S., Willing, M., Estrera, A., Safi, H., Hannibal, M. C., Carey, J., Wiktorowicz, J., Tan, F. K., Feng, X. H., Pannu, H. and Milewicz, D. M. (2010). TGFBR2 mutations alter smooth muscle cell phenotype and predispose to thoracic aortic aneurysms and dissections. Cardiovasc Res 88(3): 520-529.
  10. Cao, J., Gong, L., Guo, D. C., Mietzsch, U., Kuang, S. Q., Kwartler, C. S., Safi, H., Estrera, A., Gambello, M. J. and Milewicz, D. M. (2010). Thoracic aortic disease in tuberous sclerosis complex: molecular pathogenesis and potential therapies in Tsc2+/- mice. Hum Mol Genet 19(10): 1908-1920.
Protocols by Callie S. Kwartler
  1. Vascular Smooth Muscle Cell Isolation and Culture from Mouse Aorta