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Elaine Tuomanen

Education

Ph.D. in Agricultural Biochemistry, Graduate School of Agriculture, The University of Tokyo, 1990

Current Position

Professor, Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Japan

Publications (since 2005)

  1. Hurwitz, J. L. and Tuomanen, E. (2016). Unveiling unexpected immune activities induced by your pneumococcal vaccine. mBio 7(1). pii: e00137-16.
  2. Doran, K. S., Fulde, M., Gratz, N., Kim, B. J., Nau, R., Prasadarao, N., Schubert-Unkmeir, A., Tuomanen, E. I. and Valentin-Weigand, P. (2016). Host-pathogen interactions in bacterial meningitis. Acta Neuropathol 131(2): 185-209. 
  3. Kamei, A., Gao, G., Neale, G., Loh, L. N., Vogel, P., Thomas, P. G., Tuomanen, E. I. and Murray, P. J. (2016). Exogenous remodeling of lung resident macrophages protects against infectious consequences of bone marrow-suppressive chemotherapy. Proc Natl Acad Sci U S A 113(41): E6153-E6161.
  4. Saumyaa, Pujanauski, L., Colino, J., Flora, M., Torres, R. M., Tuomanen, E. and Snapper, C. M. (2016). Pneumococcal Surface Protein A Plays a Major Role in Streptococcus pneumoniae-Induced Immunosuppression. J Immunol 196(9): 3677-3685.
  5. Humann, J., Mann, B., Gao, G., Moresco, P., Ramahi, J., Loh, L. N., Farr, A., Hu, Y., Durick-Eder, K., Fillon, S. A., Smeyne, R. J. and Tuomanen, E. I. (2016). Bacterial Peptidoglycan Transverses the Placenta to Induce Fetal Neuroproliferation and Aberrant Postnatal Behavior. Cell Host Microbe 19(3): 388-399.
  6. Kietzman, C. C., Gao, G., Mann, B., Myers, L. and Tuomanen, E. I. (2016). Dynamic capsule restructuring by the main pneumococcal autolysin LytA in response to the epithelium. Nat Commun 7: 10859.
  7. Inagaki, K., Song, M. S., Crumpton, J. C., DeBeauchamp, J., Jeevan, T., Tuomanen, E. I., Webby, R. J. and Hakim, H. (2016). Correlation Between the Interval of Influenza Virus Infectivity and Results of Diagnostic Assays in a Ferret Model. J Infect Dis 213(3): 407-410.
  8. Brown, L. R., Gunnell, S. M., Cassella, A. N., Keller, L. E., Scherkenbach, L. A., Mann, B., Brown, M. W., Hill, R., Fitzkee, N. C., Rosch, J. W., Tuomanen, E. I. and Thornton, J. A. (2016). AdcAII of Streptococcus pneumoniae Affects Pneumococcal Invasiveness. PLoS One 11(1): e0146785.
  9. Chen, A., Mann, B., Gao, G., Heath, R., King, J., Maissoneuve, J., Alderson, M., Tate, A., Hollingshead, S. K., Tweten, R. K., Briles, D. E., Tuomanen, E. I. and Paton, J. C. (2015). Multivalent Pneumococcal Protein Vaccines Comprising Pneumolysoid with Epitopes/Fragments of CbpA and/or PspA Elicit Strong and Broad Protection. Clin Vaccine Immunol 22(10): 1079-1089.
  10. Tuomanen E. (2015). Pneumococcal Vaccination in Children. In Up To Date.
  11. Tuomanen E. (2015). Pneumococcal vaccination in adults. In Up To Date.
  12. Tuomanen E. (2015). Pneumococcal pneumonia. In Up To Date.
  13. Tuomanen E. (2015). Pneumococcal meningitis. In Up To Date.
  14. Hurwitz, J., Orihuela, C., DiRita, V. J. and Tuomanen, E. (2015). Bacterial Interactions with Mucosa! Epithelial Cells. ln: Mestecky, Russell, Kelsall, Ogra, Strober Lambrecht and Cheroutre. (eds). Mucosa Imrnunology Elsevier Press.
  15. Gratz, N., Loh, L. and Tuomanen, E. (2015). Pneumococcal invasion: development of bacteremia and meningitis. In: Brown, J., Hammerschmidt, S. and Orihuela, C. (eds). Streotococcus oneumoniae: Molecular mechanisms of host-oathogen interactions. Elsevier
  16. Valentino, M. D., McGuire, A. M., Rosch, J. W., Bispo, P. J., Burnham, C., Sanfilippo, C. M., Carter, R. A., Zegans, M. E., Beall, B., Earl, A. M., Tuomanen, E. I., Morris, T. W., Haas, W. and Gilmore, M. S. (2014). Unencapsulated Streptococcus pneumoniae from conjunctivitis encode variant traits and belong to a distinct phylogenetic cluster. Nat Commun 5: 5411.
  17. Brown, A. O., Mann, B., Gao, G., Hankins, J. S., Humann, J., Giardina, J., Faverio, P., Restrepo, M. I., Halade, G. V., Mortensen, E. M., Lindsey, M. L., Hanes, M., Happel, K. I., Nelson, S., Bagby, G. J., Lorent, J. A., Cardinal, P., Granados, R., Esteban, A., LeSaux, C. J., Tuomanen, E. I. and Orihuela, C. J. (2014). Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions that disrupt cardiac function. PLoS Pathog 10(9): e1004383.
  18. Mann, B., Thornton, J., Heath, R., Wade, K. R., Tweten, R. K., Gao, G., El Kasmi, K., Jordan, J. B., Mitrea, D. M., Kriwacki, R., Maisonneuve, J., Alderson, M. and Tuomanen, E. I. (2014). Broadly protective protein-based pneumococcal vaccine composed of pneumolysin toxoid-CbpA peptide recombinant fusion protein. J Infect Dis 209(7): 1116-1125.
  19. Carter, R., Wolf, J., van Opijnen, T., Muller, M., Obert, C., Burnham, C., Mann, B., Li, Y., Hayden, R. T., Pestina, T., Persons, D., Camilli, A., Flynn, P. M., Tuomanen, E. I. and Rosch, J. W. (2014). Genomic analyses of pneumococci from children with sickle cell disease expose host-specific bacterial adaptations and deficits in current interventions. Cell Host Microbe 15(5): 587-599.
  20. Rosch, J. W., Iverson, A. R., Humann, J., Mann, B., Gao, G., Vogel, P., Mina, M., Murrah, K. A., Perez, A. C., Edward Swords, W., Tuomanen, E. I. and McCullers, J. A. (2014). A live-attenuated pneumococcal vaccine elicits CD4+ T-cell dependent class switching and provides serotype independent protection against acute otitis media. EMBO Mol Med 6(1): 141-154.
  21. LeMessurier, K. S., Hacker, H., Chi, L., Tuomanen, E. and Redecke, V. (2013). Type I interferon protects against pneumococcal invasive disease by inhibiting bacterial transmigration across the lung. PLoS Pathog 9(11): e1003727.
  22. Tuomanen E. (2013). Pneumococcal Vaccination in Children. In Up To Date.
  23. Tuomanen E. (2013). Pneumococcal pneumonia. In Up To Date.
  24. Tuomanen E. (2013). Pneumococcal meningitis. In Up To Date.
Protocols by Elaine Tuomanen
  1. Preparation of Purified Gram-positive Bacterial Cell Wall and Detection in Placenta and Fetal Tissues