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Francesc Xavier Avilés

Education

Ph.D in Chemistry, speciality Biochemistry, Institut for Fundamental Biology (IBF), Universitat Autonoma de Barcelona (UAB), 1975

Current Position

Full Professor at the Department of Biochemistry and Molecular Biology (and outgoing Director of the Dept.), and group leader at Institute for Biotechnology and Biomedicine (IBB), both at the Universitat Autonoma de Barcelona, Bellaterra (Barcelona). Spain

Publications (selected)

  1. Tanco, S., Tort, O., Demol, H., Aviles, F. X., Gevaert, K., Van Damme, P. and Lorenzo, J. (2015). C-terminomics screen for natural substrates of cytosolic carboxypeptidase 1 reveals processing of acidic protein C termini. Mol Cell Proteomics 14(1): 177-190.
  2. Lorenzo, J., Delgado, A., Montana, A. M., Mesas, J. M., Alegre, M. T., Rodriguez Mdel, C. and Aviles, F. X. (2014). Synthesis, biological evaluation and SAR studies of novel bicyclic antitumor platinum(IV) complexes. Eur J Med Chem 83: 374-388.
  3. Tanco, S., Lorenzo, J., Garcia-Pardo, J., Degroeve, S., Martens, L., Aviles, F. X., Gevaert, K. and Van Damme, P. (2013). Proteome-derived peptide libraries to study the substrate specificity profiles of carboxypeptidases. Mol Cell Proteomics 12(8): 2096-2110.
  4. Alonso-del-Rivero, M., Trejo, S. A., Reytor, M. L., Rodriguez-de-la-Vega, M., Delfin, J., Diaz, J., Gonzalez-Gonzalez, Y., Canals, F., Chavez, M. A. and Aviles, F. X. (2012). Tri-domain bifunctional inhibitor of metallocarboxypeptidases A and serine proteases isolated from marine annelid Sabellastarte magnifica. J Biol Chem 287(19): 15427-15438.
  5. Bronsoms, S., Pantoja-Uceda, D., Gabrijelcic-Geiger, D., Sanglas, L., Aviles, F. X., Santoro, J., Sommerhoff, C. P. and Arolas, J. L. (2011). Oxidative folding and structural analyses of a Kunitz-related inhibitor and its disulfide intermediates: functional implications. J Mol Biol 414(3): 427-441.
  6. Van Damme, P., Staes, A., Bronsoms, S., Helsens, K., Colaert, N., Timmerman, E., Aviles, F. X., Vandekerckhove, J. and Gevaert, K. (2010). Complementary positional proteomics for screening substrates of endo- and exoproteases. Nat Methods 7(7): 512-515.
  7. Morell, M., Ventura, S. and Aviles, F. X. (2009). Protein complementation assays: approaches for the in vivo analysis of protein interactions. FEBS Lett 583(11): 1684-1691.
  8. Sanglas, L., Aviles, F. X., Huber, R., Gomis-Ruth, F. X. and Arolas, J. L. (2009). Mammalian metallopeptidase inhibition at the defense barrier of Ascaris parasite. Proc Natl Acad Sci U S A 106(6): 1743-1747.
  9. Anand, K., Pallares, I., Valnickova, Z., Christensen, T., Vendrell, J., Wendt, K. U., Schreuder, H. A., Enghild, J. J. and Aviles, F. X. (2008). The crystal structure of thrombin-activable fibrinolysis inhibitor (TAFI) provides the structural basis for its intrinsic activity and the short half-life of TAFIa. J Biol Chem 283(43): 29416-29423.
  10. Arolas, J. L., Pantoja-Uceda, D., Ventura, S., Blanco, F. J. and Aviles, F. X. (2008). The NMR structures of the major intermediates of the two-domain tick carboxypeptidase inhibitor reveal symmetry in its folding and unfolding pathways. J Biol Chem 283(40): 27110-27120.
Protocols by Francesc Xavier Avilés
  1. Microplate Assay to Study Carboxypeptidase A Inhibition in Andean Potatoes