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Paul John Brighton

Education

Ph.D. in Department of Cell Physiology and Pharmacology, University of Leicester, 2005

Current Position

Senior Post-Doctoral Research Fellow, University of Warwick, 2014

Publications

  1. Muter, J., Brighton, P. J., Lucas, E. S., Lacey, L., Shmygol, A., Quenby, S., Blanks, A. M. and Brosens, J. J. (2016). Progesterone-Dependent Induction of Phospholipase C-Related Catalytically Inactive Protein 1 (PRIP-1) in Decidualizing Human Endometrial Stromal Cells. Endocrinology 157(7): 2883-2893.

  2. Lucas, E. S., Dyer, N. P., Murakami, K., Lee, Y. H., Chan, Y. W., Grimaldi, G., Muter, J., Brighton, P. J., Moore, J. D., Patel, G., Chan, J. K., Takeda, S., Lam, E. W., Quenby, S., Ott, S. and Brosens, J. J. (2016). Loss of Endometrial Plasticity in Recurrent Pregnancy Loss. Stem Cells 34(2): 346-356.
  3. Willets, J. M., Brighton, P. J., Windell, L. N., Rana, S., Nash, C. A. and Konje, J. C. (2015). Bradykinin-activated contractile signalling pathways in human myometrial cells are differentially regulated by arrestin proteins. Mol Cell Endocrinol 407: 57-66.
  4. Muter, J., Lucas, E. S., Chan, Y. W., Brighton, P. J., Moore, J. D., Lacey, L., Quenby, S., Lam, E. W. and Brosens, J. J. (2015). The clock protein period 2 synchronizes mitotic expansion and decidual transformation of human endometrial stromal cells. FASEB J 29(4): 1603-1614.
  5. Tovey, S. C., Brighton, P. J., Bampton, E. T., Huang, Y. and Willars, G. B. (2013). Confocal microscopy: theory and applications for cellular signaling. Methods Mol Biol 937: 51-93.
  6. Morris, G. E., Nelson, C. P., Brighton, P. J., Standen, N. B., Challiss, R. A. and Willets, J. M. (2012). Arrestins 2 and 3 differentially regulate ETA and P2Y2 receptor-mediated cell signaling and migration in arterial smooth muscle. Am J Physiol Cell Physiol 302(5): C723-734.
  7. Brighton, P. J., Marczylo, T. H., Rana, S., Konje, J. C. and Willets, J. M. (2011). Characterization of the endocannabinoid system, CB(1) receptor signalling and desensitization in human myometrium. Br J Pharmacol 164(5): 1479-1494.
  8. Brighton, P. J., Rana, S., Challiss, R. J., Konje, J. C. and Willets, J. M. (2011). Arrestins differentially regulate histamine- and oxytocin-evoked phospholipase C and mitogen-activated protein kinase signalling in myometrial cells. Br J Pharmacol 162(7): 1603-1617.
  9. Morris, G. E., Nelson, C. P., Everitt, D., Brighton, P. J., Standen, N. B., Challiss, R. A. and Willets, J. M. (2011). G protein-coupled receptor kinase 2 and arrestin2 regulate arterial smooth muscle P2Y-purinoceptor signalling. Cardiovasc Res 89(1): 193-203.
  10. Brighton, P. J., McDonald, J., Taylor, A. H., Challiss, R. A., Lambert, D. G., Konje, J. C. and Willets, J. M. (2009). Characterization of anandamide-stimulated cannabinoid receptor signaling in human ULTR myometrial smooth muscle cells. Mol Endocrinol 23(9): 1415-1427.
  11. Willets, J. M., Brighton, P. J., Mistry, R., Morris, G. E., Konje, J. C. and Challiss, R. A. (2009). Regulation of oxytocin receptor responsiveness by G protein-coupled receptor kinase 6 in human myometrial smooth muscle. Mol Endocrinol 23(8): 1272-1280.
  12. Kakaoula, K., Tovey, S. C., Brighton, P. J. and Willars, G. B. (2008). Lack of receptor selective effects of either RGS2, RGS3 or RGS4 on muscarinic M3- and GnRH-receptor-mediated signalling through Gαq/11. Eur J Pharmacol 587(1-3): 16-24.
  13. Brighton, P. J., Wise, A., Dass, N. B. and Willars, G. B. (2008). Paradoxical behavior of neuromedin U in isolated smooth muscle cells and intact tissue. J Pharmacol Exp Ther 325(1): 154-164.
  14. Tovey, S. C., Brighton, P. J. and Willars, G. B. (2006). Confocal microscopy: theory and applications for cellular signaling. Methods Mol Biol 312: 57-85.
  15. Brighton, P. J., Szekeres, P. G., Wise, A. and Willars, G. B. (2004). Signaling and ligand binding by recombinant neuromedin U receptors: evidence for dual coupling to Galphaq/11 and Galphai and an irreversible ligand-receptor interaction. Mol Pharmacol 66(6): 1544-1556.
  16. Brighton, P. J., Szekeres, P. G. and Willars, G. B. (2004). Neuromedin U and its receptors: structure, function, and physiological roles. Pharmacol Rev 56(2): 231-248.
Protocols by Paul John Brighton
  1. Isolation and Primary Culture of Various Cell Types from Whole Human Endometrial Biopsies