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Louis J. Picker

Education

M.D. in Medicine, University of California, San Francisco, CA, 1982

Current position

Associate Director, Vaccine and Gene Therapy Institute (VGTI), Oregon Health & Science University
Professor in Pathology and Molecular Microbiology & Immunology, OHSU
Senior Scientist, Oregon National Primate Research Center (ONPRC)

Publications (selected out of 172 total)

  1. Malouli, D., Hansen, S. G., Nakayasu, E. S., Marshall, E. E., Hughes, C. M., Ventura, A. B., Gilbride, R. M., Lewis, M. S., Xu, G., Kreklywich, C., Whizin, N., Fischer, M., Legasse, A. W., Viswanathan, K., Siess, D., Camp, D. G., 2nd, Axthelm, M. K., Kahl, C., Defilippis, V. R., Smith, R. D., Streblow, D. N., Picker, L. J.* and Fruh, K.* (2014). Cytomegalovirus pp65 limits dissemination but is dispensable for persistence. J Clin Invest. (Epub ahead of print) (*Co-corresponding authors)
  2. Hansen, S. G., Piatak, M., Jr., Ventura, A. B., Hughes, C. M., Gilbride, R. M., Ford, J. C., Oswald, K., Shoemaker, R., Li, Y., Lewis, M. S., Gilliam, A. N., Xu, G., Whizin, N., Burwitz, B. J., Planer, S. L., Turner, J. M., Legasse, A. W., Axthelm, M. K., Nelson, J. A., Fruh, K., Sacha, J. B., Estes, J. D., Keele, B. F., Edlefsen, P. T., Lifson, J. D. and Picker, L. J. (2013). Immune clearance of highly pathogenic SIV infection. Nature 502(7469): 100-104.
  3. Hansen, S. G., Sacha, J. B., Hughes, C. M., Ford, J. C., Burwitz, B. J., Scholz, I., Gilbride, R. M., Lewis, M. S., Gilliam, A. N., Ventura, A. B., Malouli, D., Xu, G., Richards, R., Whizin, N., Reed, J. S., Hammond, K. B., Fischer, M., Turner, J. M., Legasse, A. W., Axthelm, M. K., Edlefsen, P. T., Nelson, J. A., Lifson, J. D., Fruh, K. and Picker, L. J. (2013). Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms. Science 340(6135): 1237874.
  4. Fukazawa, Y., Park, H., Cameron, M. J., Lefebvre, F., Lum, R., Coombes, N., Mahyari, E., Hagen, S. I., Bae, J. Y., Reyes, M. D., 3rd, Swanson, T., Legasse, A. W., Sylwester, A., Hansen, S. G., Smith, A. T., Stafova, P., Shoemaker, R., Li, Y., Oswald, K., Axthelm, M. K., McDermott, A., Ferrari, G., Montefiori, D. C., Edlefsen, P. T., Piatak, M., Jr., Lifson, J. D., Sekaly, R. P. and Picker, L. J. (2012). Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines. Nat Med 18(11): 1673-1681.
  5. Okoye, A. A., Rohankhedkar, M., Abana, C., Pattenn, A., Reyes, M., Pexton, C., Lum, R., Sylwester, A., Planer, S. L., Legasse, A., Park, B. S., Piatak, M., Jr., Lifson, J. D., Axthelm, M. K. and Picker, L. J. (2012). Naive T cells are dispensable for memory CD4+ T cell homeostasis in progressive simian immunodeficiency virus infection. J Exp Med 209(4): 641-651.
  6. Picker, L. J., Hansen, S. G. and Lifson, J. D. (2012). New paradigms for HIV/AIDS vaccine development. Annu Rev Med 63: 95-111.
  7. Hansen, S. G., Ford, J. C., Lewis, M. S., Ventura, A. B., Hughes, C. M., Coyne-Johnson, L., Whizin, N., Oswald, K., Shoemaker, R., Swanson, T., Legasse, A. W., Chiuchiolo, M. J., Parks, C. L., Axthelm, M. K., Nelson, J. A., Jarvis, M. A., Piatak, M., Jr., Lifson, J. D. and Picker, L. J. (2011). Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature 473(7348): 523-527.
  8. Hansen, S. G., Powers, C. J., Richards, R., Ventura, A. B., Ford, J. C., Siess, D., Axthelm, M. K., Nelson, J. A., Jarvis, M. A., Picker, L. J.* and Fruh, K.* (2010). Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus. Science 328(5974): 102-106. (*Co-corresponding authors)
  9. Okoye, A., Park, H., Rohankhedkar, M., Coyne-Johnson, L., Lum, R., Walker, J. M., Planer, S. L., Legasse, A. W., Sylwester, A. W., Piatak, M., Jr., Lifson, J. D., Sodora, D. L., Villinger, F., Axthelm, M. K., Schmitz, J. E. and Picker, L. J. (2009). Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis. J Exp Med 206(7): 1575-1588.
  10. Kuhrt, D., Faith, S. A., Leone, A., Rohankedkar, M., Sodora, D. L., Picker, L. J. and Cole, K. S. (2010). Evidence of early B-cell dysregulation in simian immunodeficiency virus infection: rapid depletion of naive and memory B-cell subsets with delayed reconstitution of the naive B-cell population. J Virol 84(5): 2466-2476.
  11. Hansen, S. G., Vieville, C., Whizin, N., Coyne-Johnson, L., Siess, D. C., Drummond, D. D., Legasse, A. W., Axthelm, M. K., Oswald, K., Trubey, C. M., Piatak, M., Jr., Lifson, J. D., Nelson, J. A., Jarvis, M. A. and Picker, L. J. (2009). Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge. Nat Med 15(3): 293-299.
  12. Grossman, Z. and Picker, L. J. (2008). Pathogenic mechanisms in simian immunodeficiency virus infection. Curr Opin HIV AIDS 3(3): 380-386.
  13. Okoye, A., Meier-Schellersheim, M., Brenchley, J. M., Hagen, S. I., Walker, J. M., Rohankhedkar, M., Lum, R., Edgar, J. B., Planer, S. L., Legasse, A., Sylwester, A. W., Piatak, M., Jr., Lifson, J. D., Maino, V. C., Sodora, D. L., Douek, D. C., Axthelm, M. K., Grossman, Z. and Picker, L. J. (2007). Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection. J Exp Med 204(9): 2171-2185.
  14. Picker, L. J., Reed-Inderbitzin, E. F., Hagen, S. I., Edgar, J. B., Hansen, S. G., Legasse, A., Planer, S., Piatak, M., Jr., Lifson, J. D., Maino, V. C., Axthelm, M. K. and Villinger, F. (2006). IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates. J Clin Invest 116(6): 1514-1524.
  15. Picker, L. J., Hagen, S. I., Lum, R., Reed-Inderbitzin, E. F., Daly, L. M., Sylwester, A. W., Walker, J. M., Siess, D. C., Piatak, M., Jr., Wang, C., Allison, D. B., Maino, V. C., Lifson, J. D., Kodama, T. and Axthelm, M. K. (2004). Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection. J Exp Med 200(10): 1299-1314.
  16. Walker, J. M., Maecker, H. T., Maino, V. C. and Picker, L. J. (2004). Multicolor flow cytometric analysis in SIV-infected rhesus macaque. Methods Cell Biol 75: 535-557.
  17. Pitcher, C. J., Hagen, S. I., Walker, J. M., Lum, R., Mitchell, B. L., Maino, V. C., Axthelm, M. K. and Picker, L. J. (2002). Development and homeostasis of T cell memory in rhesus macaque. J Immunol 168(1): 29-43.
Protocols by Louis J. Picker
  1. Quantification of T Cell Antigen-specific Memory Responses in Rhesus Macaques, Using Cytokine Flow Cytometry (CFC, also Known as ICS and ICCS): Analysis of Flow Data
  2. Quantification of T Cell Antigen-specific Memory Responses in Rhesus Macaques, Using Cytokine Flow Cytometry (CFC, also Known as ICS and ICCS): from Assay Set-up to Data Acquisition