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Yong-Jing Gao

Education

Ph.D in Neurobiology, Fudan University, China, 2004

Current Position

Professor and vice-dean in Institute of Nautical Medicine, Nantong University, Jiangsu China

Publications

  1. Jiang, B. C., Cao, D. L., Zhang, X., Zhang, Z. J., He, L. N., Li, C. H., Zhang, W. W., Wu, X. B., Berta, T., Ji, R. R. and Gao, Y. J. (2016). CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5. J Clin Invest 126(2): 745-761.
  2. Zhang, Q., Cao, D. L., Zhang, Z. J., Jiang, B. C. and Gao, Y. J. (2016). Chemokine CXCL13 mediates orofacial neuropathic pain via CXCR5/ERK pathway in the trigeminal ganglion of mice. J Neuroinflammation 13(1): 183.
  3. Jiang, B. C., Sun, W. X., He, L. N., Cao, D. L., Zhang, Z. J. and Gao, Y. J. (2015). Identification of lncRNA expression profile in the spinal cord of mice following spinal nerve ligation-induced neuropathic pain. Mol Pain 11: 43.
  4. Chen, J. J., Dai, L., Zhao, L. X., Zhu, X., Cao, S. and Gao, Y. J. (2015). Intrathecal curcumin attenuates pain hypersensitivity and decreases spinal neuroinflammation in rat model of monoarthritis. Sci Rep 5: 10278.
  5. Shen, Y., Zhang, Z. J., Zhu, M. D., Jiang, B. C., Yang, T. and Gao, Y. J. (2015). Exogenous induction of HO-1 alleviates vincristine-induced neuropathic pain by reducing spinal glial activation in mice. Neurobiol Dis 79: 100-110.
  6. Lu, Y., Cao, D. L., Jiang, B. C., Yang, T. and Gao, Y. J. (2015). MicroRNA-146a-5p attenuates neuropathic pain via suppressing TRAF6 signaling in the spinal cord. Brain Behav Immun 49: 119-129.
  7. Lu, Y., Jiang, B. C., Cao, D. L., Zhang, Z. J., Zhang, X., Ji, R. R. and Gao, Y. J. (2014). TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-alpha and IL-1beta signaling. Pain 155(12): 2618-2629.
  8. Cao, D. L., Zhang, Z. J., Xie, R. G., Jiang, B. C., Ji, R. R. and Gao, Y. J. (2014). Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2. Exp Neurol 261: 328-336.
  9. Zhu, X., Cao, S., Zhu, M. D., Liu, J. Q., Chen, J. J. and Gao, Y. J. (2014). Contribution of chemokine CCL2/CCR2 signaling in the dorsal root ganglion and spinal cord to the maintenance of neuropathic pain in a rat model of lumbar disc herniation. J Pain 15(5): 516-526.
  10. Zhao, L. X., Jiang, B. C., Wu, X. B., Cao, D. L. and Gao, Y. J. (2014). Ligustilide attenuates inflammatory pain via inhibition of NFkappaB-mediated chemokines production in spinal astrocytes. Eur J Neurosci 39(8): 1391-1402.
  11. Xu, J., Zhu, M. D., Zhang, X., Tian, H., Zhang, J. H., Wu, X. B. and Gao, Y. J. (2014). NFkappaB-mediated CXCL1 production in spinal cord astrocytes contributes to the maintenance of bone cancer pain in mice. J Neuroinflammation 11: 38.
  12. Zhang, Z. J., Cao, D. L., Zhang, X., Ji, R. R. and Gao, Y. J. (2013). Chemokine contribution to neuropathic pain: respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons. Pain 154(10): 2185-2197.
  13. Lu, Y., Zhao, L. X., Cao, D. L. and Gao, Y. J. (2013). Spinal injection of docosahexaenoic acid attenuates carrageenan-induced inflammatory pain through inhibition of microglia-mediated neuroinflammation in the spinal cord. Neuroscience 241: 22-31.
  14. Lu, Y., Zhao, L. X., Cao, D. L. and Gao, Y. J. (2013). Spinal injection of docosahexaenoic acid attenuates carrageenan-induced inflammatory pain through inhibition of microglia-mediated neuroinflammation in the spinal cord. Neuroscience 241: 22-31.
  15. Zhang, Z. J., Dong, Y. L., Lu, Y., Cao, S., Zhao, Z. Q. and Gao, Y. J. (2012). Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain. J Neuroinflammation 9: 136.
  16. Gao, Y. J. and Ji, R. R. (2010). Light touch induces ERK activation in superficial dorsal horn neurons after inflammation: involvement of spinal astrocytes and JNK signaling in touch-evoked central sensitization and mechanical allodynia. J Neurochem 115(2): 505-514.
  17. Gao, Y. J., Zhang, L. and Ji, R. R. (2010). Spinal injection of TNF-alpha-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1. Glia 58(15): 1871-1880.
  18. Gao, Y. J. and Ji, R. R. (2010). Targeting astrocyte signaling for chronic pain. Neurotherapeutics 7(4): 482-493.
  19. Gao, Y. J. and Ji, R. R. (2010). Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. Pharmacol Ther 126(1): 56-68.
  20. Gao, Y. J., Xu, Z. Z., Liu, Y. C., Wen, Y. R., Decosterd, I. and Ji, R. R. (2010). The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition. Pain 148(2): 309-319.
  21. Gao, Y. J., Zhang, L., Samad, O. A., Suter, M. R., Yasuhiko, K., Xu, Z. Z., Park, J. Y., Lind, A. L., Ma, Q. and Ji, R. R. (2009). JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. J Neurosci 29(13): 4096-4108.
  22. Gao, Y. J., Cheng, J. K., Zeng, Q., Xu, Z. Z., Decosterd, I., Xu, X. and Ji, R. R. (2009). Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model. Exp Neurol 219(1): 146-155.
Protocols by Yong-Jing Gao
  1. Microinjection of Virus into Lumbar Enlargement of Spinal Dorsal Horn in Mice