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John P Phelan

Education

Ph.D Biochemistry, University College London, London, England, 2005

Current Position

Research Scientist, Biomerit Research Centre, Department of Microbiology, University College Cork, Ireland

Publications

  1. Phelan, J. P., Reen, F. J., Dunphy, N., O'Connor, R. and O'Gara, F. (2016). Bile acids destabilise HIF-1alpha and promote anti-tumour phenotypes in cancer cell models. BMC Cancer 16: 476.
  2. Reen, F. J., Phelan, J. P., Gallagher, L., Woods, D. F., Shanahan, R. M., Cano, R., E, O. M., McGlacken, G. P. and O'Gara, F. (2016). Exploiting Interkingdom Interactions for Development of Small-Molecule Inhibitors of Candida albicans Biofilm Formation. Antimicrob Agents Chemother 60(10): 5894-5905.
  3. Frey-Klett, P., Burlinson, P., Deveau, A., Barret, M., Tarkka, M. and Sarniguet, A. (2011). Bacterial-fungal interactions: hyphens between agricultural, clinical, environmental, and food microbiologists. Microbiol Mol Biol Rev 75(4): 583-609.
  4. Wekesa, A. L., Doyle, L. M., Fitzmaurice, D., O'Donovan, O., Phelan, J. P., Ross, M. D., Cross, K. S. and Harrison, M. (2016). Influence of a low-carbohydrate diet on endothelial microvesicles in overweight women. Appl Physiol Nutr Metab 41(5): 522-527.
  5. Wekesa, A. L., Cross, K. S., O'Donovan, O., Dowdall, J. F., O'Brien, O., Doyle, M., Byrne, L., Phelan, J. P., Ross, M. D., Landers, R. and Harrison, M. (2014). Predicting carotid artery disease and plaque instability from cell-derived microparticles. Eur J Vasc Endovasc Surg 48(5): 489-495.
  6. Al Khudairy, A. and Phelan, J. P. (2014). Letter to the editor: in vitro elution characteristics of vancomycin in a composite calcium phosphate/calcium sulfate bone substitute. HSS J 10(1): 98.
  7. Ross, M. D., Wekesa, A. L., Phelan, J. P. and Harrison, M. (2014). Resistance exercise increases endothelial progenitor cells and angiogenic factors. Med Sci Sports Exerc 46(1): 16-23.
  8. Agromayor, M., Carlton, J. G., Phelan, J. P., Matthews, D. R., Carlin, L. M., Ameer-Beg, S., Bowers, K. and Martin-Serrano, J. (2009). Essential role of hIST1 in cytokinesis. Mol Biol Cell 20(5): 1374-1387.
  9. Zhai, C., Li, K., Markaki, V., Phelan, J. P., Bowers, K., Cooke, F. T. and Panaretou, B. (2008). Ypp1/YGR198w plays an essential role in phosphoinositide signalling at the plasma membrane. Biochem J 415(3): 455-466.
  10. Phelan, J. P., Millson, S. H., Parker, P. J., Piper, P. W. and Cooke, F. T. (2006). Fab1p and AP-1 are required for trafficking of endogenously ubiquitylated cargoes to the vacuole lumen in S. cerevisiae. J Cell Sci 119(Pt 20): 4225-4234.
  11. Mollapour, M., Phelan, J. P., Millson, S. H., Piper, P. W. and Cooke, F. T. (2006). Weak acid and alkali stress regulate phosphatidylinositol bisphosphate synthesis in Saccharomyces cerevisiae. Biochem J 395(1): 73-80.
  12. Hinks, J. A., Roe, M., Ho, J. C., Watts, F. Z., Phelan, J., McAllister, M. and Pearl, L. H. (2003). Expression, purification and preliminary X-ray analysis of the BRCT domain from Rhp9/Crb2. Acta Crystallogr D Biol Crystallogr 59(Pt 7): 1230-1233.
  13. Garavini, H., Riento, K., Phelan, J. P., McAlister, M. S., Ridley, A. J. and Keep, N. H. (2002). Crystal structure of the core domain of RhoE/Rnd3: a constitutively activated small G protein. Biochemistry 41(20): 6303-6310.
  14. Ceschini, S., Keeley, A., McAlister, M. S., Oram, M., Phelan, J., Pearl, L. H., Tsaneva, I. R. and Barrett, T. E. (2001). Crystal structure of the fission yeast mitochondrial Holliday junction resolvase Ydc2. EMBO J 20(23): 6601-6611.
  15. Knight, D., Harris, R., McAlister, M. S., Phelan, J. P., Geddes, S., Moss, S. J., Driscoll, P. C., Keep, N. H. (2001). The X-ray crystal structure and putative ligand-derived peptide-binding properties of GABAA receptor associated protein (GABARAP). J Biol Chem 15:5556-5561.
  16. Harris, R., McAlister, M. S., Sankar, A., Phelan, J. P., Moss, S. J., Keep, N. H. and Driscoll, P. C. (2001). Backbone 1H, 13C, and 15N resonance assignments for a 14 kD protein, GABA(A) receptor associated protein (GABARAP). J Biomol NMR 21(2): 185-186.
  17. Murray-Rust, J., Leiper, J. M., McAlister, M. S. B., Phelan, J., Tilley, S., Santa-Maria, J., Vallance, P. J. T. and McDonald, N. Q. (2001). Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase. Nature Structural Biology 8:679-683.
  18. Hoyle, J., Phelan, J. P., Bermingham, N. and Fisher, E. M. (1996). Localization of human and mouse N-ethylmaleimide-sensitive factor (NSF) gene: a two-domain member of the AAA family that is involved in membrane fusion. Mamm Genome 7(11): 850-852.
Protocols by John P Phelan
  1. Determining the Influence of Small Molecules on Hypoxic Prostate Cancer Cell (DU-145) Viability Using Automated Cell Counting and a Cell Harvesting Protocol