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Michel Lafleur

Education

Ph.D in Chemistry,  Université Laval,  1987

Current Position

Professor, Chemistry Department, Université de Montréal

Publications (since 2010)

  1. Paz Ramos, A., Lague, P., Lamoureux, G. and Lafleur, M. (2016). Effect of Saturated Very Long-Chain Fatty Acids on the Organization of Lipid Membranes: A Study Combining (2)H NMR Spectroscopy and Molecular Dynamics Simulations. J Phys Chem B 120(28): 6951-6960.
  2. Felfoul, O., Mohammadi, M., Taherkhani, S., de Lanauze, D., Zhong Xu, Y., Loghin, D., Essa, S., Jancik, S., Houle, D., Lafleur, M., Gaboury, L., Tabrizian, M., Kaou, N., Atkin, M., Vuong, T., Batist, G., Beauchemin, N., Radzioch, D. and Martel, S. (2016). Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions. Nat Nanotechnol.
  3. Therrien, A., Fournier, A. and Lafleur, M. (2016). Role of the Cationic C-Terminal Segment of Melittin on Membrane Fragmentation. J Phys Chem B 120(17): 3993-4002.
  4. Therrien, A., Fournier, A. and Lafleur, M. (2016). Role of the Cationic C-Terminal Segment of Melittin on Membrane Fragmentation. J Phys Chem B 120: 3993-4002.
  5. Therrien, A. and Lafleur, M. (2016). Melittin-Induced Lipid Extraction Modulated by the Methylation Level of Phosphatidylcholine Headgroups. Biophys J 110(2): 400-410.
  6. Plante, G., Prud'homme, B., Fan, J., Lafleur, M. and Manjunath, P. (2016). Evolution and function of mammalian binder of sperm proteins. Cell Tissue Res 363(1): 105-127.
  7. Ramos, A. P. and Lafleur, M. (2015). Chain Length of Free Fatty Acids Influences the Phase Behavior of Stratum Corneum Model Membranes. Langmuir 31(42): 11621-11629.
  8. Plante, G., Lusignan, M. F., Lafleur, M. and Manjunath, P. (2015). Interaction of milk proteins and Binder of Sperm (BSP) proteins from boar, stallion and ram semen. Reprod Biol Endocrinol 13: 92.
  9. Essa, S., Daoud, J., Lafleur, M., Martel, S. and Tabrizian, M. (2015). SN-38 active loading in poly(lactic-co-glycolic acid) nanoparticles and assessment of their anticancer properties on COLO-205 human colon adenocarcinoma cells. J Microencapsul 32(8): 784-793.
  10. Cui, Z. K., Phoeung, T., Rousseau, P. A., Rydzek, G., Zhang, Q., Bazuin, C. G. and Lafleur, M. (2014). Nonphospholipid fluid liposomes with switchable photocontrolled release. Langmuir 30(36): 10818-10825.
  11. Cottenye, N., Carbajal, G., Cui, Z. K., Ducharme, P. D., Mauzeroll, J. and Lafleur, M. (2014). Formation, stability, and pH sensitivity of free-floating, giant unilamellar vesicles using palmitic acid-cholesterol mixtures. Soft Matter 10(34): 6451-6456.
  12. Cui, Z. K., Edwards, K., Nieto Orellana, A., Bastiat, G., Benoit, J. P. and Lafleur, M. (2014). Impact of interfacial cholesterol-anchored polyethylene glycol on sterol-rich non-phospholipid liposomes. J Colloid Interface Sci 428: 111-120.
  13. Cui, Z. K. and Lafleur, M. (2014). Lamellar self-assemblies of single-chain amphiphiles and sterols and their derived liposomes: distinct compositions and distinct properties. Colloids Surf B Biointerfaces 114: 177-185.
  14. Leroy, M., Lafleur, M., Auger, M., Laroche, G. and Pouliot, R. (2013). Characterization of the structure of human skin substitutes by infrared microspectroscopy. Anal Bioanal Chem 405(27): 8709-8718.
  15. Cottenye, N., Cui, Z. K., Wilkinson, K. J., Barbeau, J. and Lafleur, M. (2013). Interactions between non-phospholipid liposomes containing cetylpyridinium chloride and biofilms of Streptococcus mutans: modulation of the adhesion and of the biodistribution. Biofouling 29(7): 817-827.
  16. Carbajal, G., Cui, Z. C. and Lafleur, M. (2013). Non-phospholipid liposomes with high sterol content display a very limited permeability. Science China Chemistry 56: 40-47.
  17. Therrien, A., Manjunath, P. and Lafleur, M. (2013). Chemical and physical requirements for lipid extraction by bovine binder of sperm BSP1. Biochim Biophys Acta 1828(2): 543-551.
  18. Cui, Z. K., Bouisse, A., Cottenye, N. and Lafleur, M. (2012). Formation of pH-sensitive cationic liposomes from a binary mixture of monoalkylated primary amine and cholesterol. Langmuir 28(38): 13668-13674.
  19. Kwak, S., Brief, E., Langlais, D., Kitson, N., Lafleur, M. and Thewalt, J. (2012). Ethanol perturbs lipid organization in models of stratum corneum membranes: An investigation combining differential scanning calorimetry, infrared and (2)H NMR spectroscopy. Biochim Biophys Acta 1818(5): 1410-1419.
  20. Lusignan, M. F., Bergeron, A., Lafleur, M. and Manjunath, P. (2011). The major proteins of bovine seminal plasma interact with caseins and whey proteins of milk extender. Biol Reprod 85(3): 457-464.
  21. Gagnon, M. A. and Lafleur, M. (2011). Comparison between nuclear magnetic resonance profiling and the source/sink approach for characterizing drug diffusion in hydrogel matrices. Pharm Dev Technol 16(6): 651-656.
  22. Gagnon, M. A. and Lafleur, M. (2011). Comparison of the structure and the transport properties of low-set and high-set curdlan hydrogels. J Colloid Interface Sci 357(2): 419-427.
  23. Lusignan, M. F., Manjunath, P. and Lafleur, M. (2011). Thermodynamics of the interaction between bovine binder of sperm BSP1 and low-density lipoproteins from hen's egg yolk. Therm Acta 516: 88-90.
  24. Lafleur, M., Courtemanche, L., Karlsson, G., Edwards, K., Schwartz, J. L. and Manjunath, P. (2010). Bovine binder-of-sperm protein BSP1 promotes protrusion and nanotube formation from liposomes. Biochem Biophys Res Commun 399(3): 406-411.
  25. Phoeung, T., Aubron, P., Rydzek, G. and Lafleur, M. (2010). pH-triggered release from nonphospholipid LUVs modulated by the pKa of the included fatty acid. Langmuir 26(15): 12769-12776.
  26. Cui, Z. K., Bastiat, G. and Lafleur, M. (2010). Formation of fluid lamellar phase and large unilamellar vesicles with octadecyl methyl sulfoxide/cholesterol mixtures. Langmuir 26(15): 12733-12739.
  27. Cui, Z. K., Bastiat, G., Jin, C., Keyvanloo, A. and Lafleur, M. (2010). Influence of the nature of the sterol on the behavior of palmitic acid/sterol mixtures and their derived liposomes. Biochim Biophys Acta 1798(6): 1144-1152.
Protocols by Michel Lafleur
  1. Determining Efficiency and Selectivity of Lipid Extraction by Perturbing Agents from Model Membranes