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Clifford A. Lowell

Education

Ph.D in Biochemistry, Cellular and Molecular Biology, Johns Hopkins University School of Medicine, 1986

Current Position

Professor and Chairman, Dept. of Laboratory Medicine, UCSF

Publications

  1. Sinha, M. and Lowell, C. A. (2016). Immune Defense Protein Expression in Highly Purified Mouse Lung Epithelial Cells. Am J Respir Cell Mol Biol 54(6): 802-813.

  2. Volmering, S., Block, H., Boras, M., Lowell, C. A. and Zarbock, A. (2016). The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation. Immunity 44(1): 73-87.
  3. Hang, L., Blum, A. M., Kumar, S., Urban, J. F., Jr., Mitreva, M., Geary, T. G., Jardim, A., Stevenson, M. M., Lowell, C. A. and Weinstock, J. V. (2016). Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis. J Immunol 197(7): 2948-2957.
  4. Nemeth, T., Mocsai, A. and Lowell, C. A. (2016). Neutrophils in animal models of autoimmune disease. Semin Immunol 28(2): 174-186.
  5. Yi, T., Li, J., Chen, H., Wu, J., An, J., Xu, Y., Hu, Y., Lowell, C. A. and Cyster, J. G. (2015). Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses. Immunity 43(4): 764-775.
  6. Nagamatsu, G., Saito, S., Takubo, K. and Suda, T. (2015). Integrative Analysis of the Acquisition of Pluripotency in PGCs Reveals the Mutually Exclusive Roles of Blimp-1 and AKT Signaling. Stem Cell Reports 5(1): 111-124.
  7. Chen, Z., Shojaee, S., Buchner, M., Geng, H., Lee, J. W., Klemm, L., Titz, B., Graeber, T. G., Park, E., Tan, Y. X., Satterthwaite, A., Paietta, E., Hunger, S. P., Willman, C. L., Melnick, A., Loh, M. L., Jung, J. U., Coligan, J. E., Bolland, S., Mak, T. W., Limnander, A., Jumaa, H., Reth, M., Weiss, A., Lowell, C. A. and Muschen, M. (2015). Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature 521(7552): 357-361.
  8. Zhang, H., Clemens, R. A., Liu, F., Hu, Y., Baba, Y., Theodore, P., Kurosaki, T. and Lowell, C. A. (2014). STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense. Blood 123(14): 2238-2249.
  9. Lamagna, C., Hu, Y., DeFranco, A. L. and Lowell, C. A. (2014). B cell-specific loss of Lyn kinase leads to autoimmunity. J Immunol 192(3): 919-928.
  10. Abram, C. L., Roberge, G. L., Hu, Y. and Lowell, C. A. (2014). Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice. J Immunol Methods 408: 89-100.
  11. Suzuki, R., Leach, S., Liu, W., Ralston, E., Scheffel, J., Zhang, W., Lowell, C. A. and Rivera, J. (2014). Molecular editing of cellular responses by the high-affinity receptor for IgE. Science 343(6174): 1021-1025.
  12. Abram, C. L., Roberge, G. L., Pao, L. I., Neel, B. G. and Lowell, C. A. (2013). Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice. Immunity 38(3): 489-501.
  13. Lamagna, C., Scapini, P., van Ziffle, J. A., DeFranco, A. L. and Lowell, C. A. (2013). Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation. Proc Natl Acad Sci U S A 110(35): E3311-3320.
  14. Graham, M. T., Abram, C. L., Hu, Y. and Lowell, C. A. (2013). Expression of the TEL-Syk fusion protein in hematopoietic stem cells leads to rapidly fatal myelofibrosis in mice. PLoS One 8(10): e77542.
  15. Elliott, E. R., Van Ziffle, J. A., Scapini, P., Sullivan, B. M., Locksley, R. M. and Lowell, C. A. (2011). Deletion of Syk in neutrophils prevents immune complex arthritis. J Immunol 187(8): 4319-4330.
  16. Kamen, L. A., Schlessinger, J. and Lowell, C. A. (2011). Pyk2 is required for neutrophil degranulation and host defense responses to bacterial infection. J Immunol 186(3): 1656-1665.
  17. Scapini, P., Lamagna, C., Hu, Y., Lee, K., Tang, Q., DeFranco, A. L. and Lowell, C. A. (2011). B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice. Proc Natl Acad Sci U S A 108(41): E823-832.
  18. Scapini, P., Hu, Y., Chu, C. L., Migone, T. S., Defranco, A. L., Cassatella, M. A. and Lowell, C. A. (2010). Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J Exp Med 207(8): 1757-1773.
  19. Van Ziffle, J. A. and Lowell, C. A. (2009). Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection. Blood 114(23): 4871-4882.
  20. Zhang, H., Schaff, U. Y., Green, C. E., Chen, H., Sarantos, M. R., Hu, Y., Wara, D., Simon, S. I. and Lowell, C. A. (2006). Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils. Immunity 25(2): 285-295.
  21. Mocsai, A., Abram, C. L., Jakus, Z., Hu, Y., Lanier, L. L. and Lowell, C. A. (2006). Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol 7(12): 1326-1333.
  22. Zhang, H., Meng, F., Chu, C. L., Takai, T. and Lowell, C. A. (2005). The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B. Immunity 22(2): 235-246.
  23. Mocsai, A., Zhou, M., Meng, F., Tybulewicz, V. L. and Lowell, C. A. (2002). Syk is required for integrin signaling in neutrophils. Immunity 16(4): 547-558.
Protocols by Clifford A. Lowell
  1. Isolation of Highly Pure Primary Mouse Alveolar Epithelial Type II Cells by Flow Cytometric Cell Sorting