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Susan Carol Barnett

Education

Ph.D. in Biochemistry, University of Sheffield, 1980.

Current position

Professor of Cellular Neuroscience, Institute of Infection Immunity and Inflammation, University of Glasgow.

Publications (since 2005)

  1. Moleirinho, S., Patrick, C., Tilston-Lunel, A. M., Higginson, J. R., Angus, L., Antkowiak, M., Barnett, S. C., Prystowsky, M. B., Reynolds, P. A. and Gunn-Moore, F. J. (2013). Willin, an upstream component of the hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts. PLoS ONE 8(4): e60028.
  2. Donoghue, P. S., Lamond, R., Boomkamp, S. D., Sun, T., Gadegaard, N., Riehle, M. O. and Barnett, S. C. (2013). The development of a epsilon-polycaprolactone scaffold for central nervous system repair. Tissue Eng Part A 19(3-4): 497-507.
  3. Lindsay, S. L., Johnstone, S. A., Mountford, J. C., Sheikh, S., Allan, D. B., Clark, L. and Barnett, S. C. (2013). Human mesenchymal stem cells isolated from olfactory biopsies but not bone enhance CNS myelination in vitro. Glia 61(3): 368-382.
  4. Barnett S. C., Linington C. (2012) Myelination: Do Astrocytes Play a Role? Neuroscientist. Nov 6. [Epub ahead of print].
  5. Moleirinho, S., Chang, N., Sims, A. H., Tilston-Lunel, A. M., Angus, L., Steele, A., Boswell, V., Barnett, S. C., Ormandy, C., Faratian, D., Gunn-Moore, F. J. and Reynolds, P. A. (2013). KIBRA exhibits MST-independent functional regulation of the Hippo signaling pathway in mammals. Oncogene 32(14): 1821-1830. [Epub ahead of print]
  6. Toft, A., Tome, M., Barnett, S. C. and Riddell, J. S. (2013). A comparative study of glial and non-neural cell properties for transplant-mediated repair of the injured spinal cord. Glia 61(4): 513-528.
  7. Higginson, J. R., Thompson, S. M., Santos-Silva, A., Guimond, S. E., Turnbull, J. E. and Barnett, S. C. (2012). Differential sulfation remodelling of heparan sulfate by extracellular 6-O-sulfatases regulates fibroblast growth factor-induced boundary formation by glial cells: implications for glial cell transplantation. J Neurosci 32(45): 15902-15912.
  8. Raisman, G., Barnett, S. C. and Ramon-Cueto, A. (2012). Repair of central nervous system lesions by transplantation of olfactory ensheathing cells. Handb Clin Neurol 109: 541-549.
  9. Elliott, C., Lindner, M., Arthur, A., Brennan, K., Jarius, S., Hussey, J., Chan, A., Stroet, A., Olsson, T., Willison, H., Barnett, S. C., Meinl, E. and Linington, C. (2012). Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis. Brain 135(Pt 6): 1819-1833.
  10. Ioannidou, K., Anderson, K. I., Strachan, D., Edgar, J. M. and Barnett, S. C. (2012). Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo. PLoS ONE 7(1): e30775.
  11. Sandvig, I., Hoang, L., Sardella, T. C., Barnett, S. C., Brekken, C., Tvedt, K., Berry, M., Haraldseth, O., Sandvig, A. and Thuen, M. (2012). Labelling of olfactory ensheathing cells with micron-sized particles of iron oxide and detection by MRI. Contrast Media Mol Imaging 7(4): 403-410.
  12. Sandvig, I., Thuen, M., Hoang, L., Olsen, O., Sardella, T. C., Brekken, C., Tvedt, K. E., Barnett, S. C., Haraldseth, O., Berry, M. and Sandvig, A. (2012). In vivo MRI of olfactory ensheathing cell grafts and regenerating axons in transplant mediated repair of the adult rat optic nerve. NMR Biomed 25(4): 620-631.
  13. Boomkamp, S. D., Riehle, M. O., Wood, J., Olson, M. F. and Barnett, S. C. (2012). The development of a rat in vitro model of spinal cord injury demonstrating the additive effects of Rho and ROCK inhibitors on neurite outgrowth and myelination. Glia 60(3): 441-456.
  14. Toft, A., Tome, M., Lindsay, S. L., Barnett, S. C. and Riddell, J. S. (2012). Transplant-mediated repair properties of rat olfactory mucosal OM-I and OM-II sphere-forming cells. J Neurosci Res 90(3): 619-631.
  15. Sun, T., Donoghue, P. S., Higginson, J. R., Gadegaard, N., Barnett, S. C. and Riehle, M. O. (2012). A miniaturized bioreactor system for the evaluation of cell interaction with designed substrates in perfusion culture. J Tissue Eng Regen Med 6 Suppl 3: s4-14.
  16. Nash, B., Thomson, C. E., Linington, C., Arthur, A. T., McClure, J. D., McBride, M. W. and Barnett, S. C. (2011). Functional duality of astrocytes in myelination. J Neurosci 31(37): 13028-13038.
  17. Brennan, K. M., Galban-Horcajo, F., Rinaldi, S., O'Leary, C. P., Goodyear, C. S., Kalna, G., Arthur, A., Elliot, C., Barnett, S., Linington, C., Bennett, J. L., Owens, G. P. and Willison, H. J. (2011). Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis. J Neuroimmunol 238(1-2): 87-95.
  18. Sun, T., Donoghue, P. S., Higginson, J. R., Gadegaard, N., Barnett, S. C. and Riehle, M. O. (2011). The interactions of astrocytes and fibroblasts with defined pore structures in static and perfusion cultures. Biomaterials 32(8): 2021-2031.
  19. Nash, B., Ioannidou, K. and Barnett, S. C. (2011). Astrocyte phenotypes and their relationship to myelination. J Anat 219(1): 44-52.
  20. Higginson, J. R. and Barnett, S. C. (2011). The culture of olfactory ensheathing cells (OECs)--a distinct glial cell type. Exp Neurol 229(1): 2-9.
  21. Lindsay, S. L., Riddell, J. S. and Barnett, S. C. (2010). Olfactory mucosa for transplant-mediated repair: a complex tissue for a complex injury? Glia 58(2): 125-134.
  22. Montague P., Kennedy PGE and Barnett S. C. (2010) Disruption of Mayven domain architecture compromises translocation of exogenous protein. BMC Neuroscience May 26, 11:63.
  23. Eisenbach, M., Kartvelishvily, E., Eshed-Eisenbach, Y., Watkins, T., Sorensen, A., Thomson, C., Ranscht, B., Barnett, S. C., Brophy, P. and Peles, E. (2009). Differential clustering of Caspr by oligodendrocytes and Schwann cells. J Neurosci Res 87(15): 3492-3501.
  24. Tome, M., Lindsay, S. L., Riddell, J. S. and Barnett, S. C. (2009). Identification of nonepithelial multipotent cells in the embryonic olfactory mucosa. Stem Cells 27(9): 2196-2208.
  25. Silajdzic, E., Willison, H. J., Furukawa, K. and Barnett, S. C. (2009). In vitro analysis of glial cell function in ganglioside-deficient mice. J Neurosci Res 87(11): 2467-2483.
  26. Thomson, C. E., McCulloch, M., Sorenson, A., Barnett, S. C., Seed, B. V., Griffiths, I. R. and McLaughlin, M. (2008). Myelinated, synapsing cultures of murine spinal cord--validation as an in vitro model of the central nervous system. Eur J Neurosci 28(8): 1518-1535.
  27. Sorensen, A., Moffat, K., Thomson, C. and Barnett, S. C. (2008). Astrocytes, but not olfactory ensheathing cells or Schwann cells, promote myelination of CNS axons in vitro. Glia 56(7): 750-763.
  28. Barnett, S. C. and Riddell, J. S. (2007). Olfactory ensheathing cell transplantation as a strategy for spinal cord repair--what can it achieve? Nat Clin Pract Neurol 3(3): 152-161.
  29. Sorensen, A., Alekseeva, T., Katechia, K., Robertson, M., Riehle, M. O. and Barnett, S. C. (2007). Long-term neurite orientation on astrocyte monolayers aligned by microtopography. Biomaterials 28(36): 5498-5508.
  30. Tome, M., Siladzic, E., Santos-Silva, A. and Barnett, S. C. (2007). Calponin is expressed by subpopulations of connective tissue cells but not olfactory ensheathing cells in the neonatal olfactory mucosa. BMC Neurosci 8: 74.
  31. Santos-Silva A, Fairless R, Frame M, Montague P, Smith GM, Toft A, Riddell JS and Barnett SC. (2007). OECs lack a heparin sulphate proteoglycan that Schwann cells use to induce the astrocyte stress response mediated via FGFR1 activation. J Neurosci. 27:7154-7167
  32. Toft, A., Scott, D. T., Barnett, S. C. and Riddell, J. S. (2007). Electrophysiological evidence that olfactory cell transplants improve function after spinal cord injury. Brain 130(Pt 4): 970-984.
  33. Dewar, D., Bentley, D. and Barnett, S. C. (2007). Implantation of pure cultured olfactory ensheathing cells in an animal model of parkinsonism. Acta Neurochir (Wien) 149(4): 407-414.
  34. Fairless, R. and Barnett, S. C. (2005). Olfactory ensheathing cells: their role in central nervous system repair. Int J Biochem Cell Biol 37(4): 693-699.
  35. Williams, S. K., Spence, H. J., Rodgers, R. R., Ozanne, B. W., Fitzgerald, U. and Barnett, S. C. (2005). Role of Mayven, a kelch-related protein in oligodendrocyte process formation. J Neurosci Res 81(5): 622-631.
  36. Fairless, R., Frame, M. C. and Barnett, S. C. (2005). N-cadherin differentially determines Schwann cell and olfactory ensheathing cell adhesion and migration responses upon contact with astrocytes. Mol Cell Neurosci 28(2): 253-263.
Protocols by Susan Carol Barnett
  1. Culture of Rat Olfactory Ensheathing Cells Using EasySep® Magnetic Nanoparticle Separation