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Guo Chen

Education

Ph.D in Biochemistry, School of Life Science, Nanjing University, China 2012

Current Position

Postdoctoral fellow, Department of Radiation Oncology, Emory University, USA

Publications

  1. Wang, X., Beitler, J. J., Huang, W., Chen, G., Nannapaneni, S., Saba, N. F., Deng, X., Chen, Z. G. and Dong, M. (2016). Survivin contributes to radiation resistance in head and neck cancer through regulation of DNA damage repair. Cancer Research 76 (14 Supplement), 515-515.

  2. Chen, G., Xu, K., Xie, M., Owonikoko, T. K., Ramalingam, S. S., Doetsch, P. W. and Deng, X. (2016). Mcl1 dictates DNA double strand break repair pathway choice. Cancer Research 76 (14 Supplement): 2757-2757.
  3. Luo, Y.,  Liu, Z. J., Chen, G., Shi, J., Li, J. R. and Zhu, H. L. (2016). 1,3,4-Oxadiazole derivatives as potential antitumor agents: discovery, optimization and biological activity valuation. Med Chem Commun 7: 263-271.
  4. Pan, F., Xu, A., Xia, D., Yu, Y., Chen, G., Meyer, M., Zhao, D., Huang, C. H., Wu, Q. and Fu, J. (2015). Effects of octahedral molecular sieve on treatment performance, microbial metabolism, and microbial community in expanded granular sludge bed reactor. Water Res 87: 127-136.
  5. Chen, G. and Deng, X. (2015). Targeting Bcl2 in cancer. Oncoscience 2(10): 813-814.
  6. Chen, G., Tang, B., Yang, B. Y., Chen, J. X., Zhou, J. H., Li, J. H. and Hua, Z. C. (2013). Tumor-targeting Salmonella typhimurium, a natural tool for activation of prodrug 6MePdR and their combination therapy in murine melanoma model. Appl Microbiol Biotechnol 97(10): 4393-4401.
  7. Chen, G., Wang, K., Yang, B. Y., Tang, B., Chen, J. X. and Hua, Z. C. (2012). Synergistic antitumor activity of oridonin and arsenic trioxide on hepatocellular carcinoma cells. Int J Oncol 40(1): 139-147.
  8. Chen, J., Yang, B., Cheng, X., Qiao, Y., Tang, B., Chen, G., Wei, J., Liu, X., Cheng, W., Du, P., Huang, X., Jiang, W., Hu, Q., Hu, Y., Li, J. and Hua, Z. C. (2012). Salmonella-mediated tumor-targeting TRAIL gene therapy significantly suppresses melanoma growth in mouse model. Cancer Sci 103(2): 325-333.
  9. Lu, X., Zhang, H., Li, X., Chen, G., Li, Q. S., Luo, Y., Ruan, B. F., Chen, X. W. and Zhu, H. L. (2011). Design, synthesis and biological evaluation of pyridine acyl sulfonamide derivatives as novel COX-2 inhibitors. Bioorg Med Chem 19(22): 6827-6832.
  10. Chen, J., Wei, D., Zhuang, H., Qiao, Y., Tang, B., Zhang, X., Wei, J., Fang, S., Chen, G., Du, P., Huang, X., Jiang, W., Hu, Q. and Hua, Z. C. (2011). Proteomic screening of anaerobically regulated promoters from Salmonella and its antitumor applications. Mol Cell Proteomics 10(6): M111 009399.
  11. Chen, G., Dai, Y., Chen, J., Wang, X., Tang, B., Zhu, Y. and Hua, Z. (2011). Oral delivery of the Sj23LHD-GST antigen by Salmonella typhimurium type III secretion system protects against Schistosoma japonicum infection in mice. PLoS Negl Trop Dis 5(9): e1313.
  12. Fu, J., Chen, G., Yang, Y., Zhang, Z. M., Zeng, Q. F., An, S. Q. and Zhu, H. L. (2010). Ultraviolet irradiation combined with manganese ore catalyzed ozonation of 4-chlorophenol in aqueous solution. Water Science and Technology: Water Supply 10(1): 97-104.
  13. Chen, G., Wei, D. P., Jia, L. J., Tang, B., Shu, L., Zhang, K., Xu, Y., Gao, J., Huang, X. F., Jiang, W. H., Hu, Q. G., Huang, Y., Wu, Q., Sun, Z. H., Zhang, J. F. and Hua, Z. C. (2009). Oral delivery of tumor-targeting Salmonella exhibits promising therapeutic efficacy and low toxicity. Cancer Sci 100(12): 2437-2443.
Protocols by Guo Chen
  1. Establishment of Patient-Derived Xenografts in Mice