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Luis Fajas

Education

Ph.D in Biochemistry, University of Barcelona, Spain, 1995

Current position

Professor, Department of Physiology, University of Lausanne, Switzerland
Director, Department of Physiology, University of Lausanne, Switzerland

Publications (2010)

  1. Rabhi, N., Denechaud, P. D., Gromada, X., Hannou, S. A., Zhang, H., Rashid, T., Salas, E., Durand, E., Sand, O., Bonnefond, A., Yengo, L., Chavey, C., Bonner, C., Kerr-Conte, J., Abderrahmani, A., Auwerx, J., Fajas, L., Froguel, P. and Annicotte, J. S. (2016). KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response. Cell Rep 15(5):1051-61.

  2. Scholz, G., Jandus, C., Zhang, L., Grandclement, C., Lopez-Mejia, I. C., Soneson, C., Delorenzi, M., Fajas, L., Held, W., Dormond, O. and Romero, P. (2016). Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T Cells. EBioMedicine 4: 50-61.

  3. Zhang, L., Tschumi, B. O., Lopez-Mejia, I. C., Oberle, S. G., Meyer, M., Samson, G., Ruegg, M. A., Hall, M. N., Fajas, L., Zehn, D., Mach, J. P., Donda, A. and Romero, P. (2016). Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner. Cell Rep 14(5): 1206-1217.

  4. Lagarrigue, S., Lopez-Mejia, I. C., Denechaud, P. D., Escote, X., Castillo-Armengol, J., Jimenez, V., Chavey, C., Giralt, A., Lai, Q., Zhang, L., Martinez-Carreres, L., Delacuisine, B., Annicotte, J. S., Blanchet, E., Hure, S., Abella, A., Tinahones, F. J., Vendrell, J., Dubus, P., Bosch, F., Kahn, C. R. and Fajas, L. (2016). CDK4 is an essential insulin effector in adipocytes. J Clin Invest 126(1): 335-348.

  5. Denechaud, P. D., Lopez-Mejia, I. C., Giralt, A., Lai, Q., Blanchet, E., Delacuisine, B., Nicolay, B. N., Dyson, N. J., Bonner, C., Pattou, F., Annicotte, J. S. and Fajas, L. (2016). E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis. J Clin Invest 126(1): 137-150.

  6. Petrov, P. D., Ribot, J., Lopez-Mejia, I. C., Fajas, L., Palou, A. and Bonet, M. L. (2016). Retinoblastoma Protein Knockdown Favors Oxidative Metabolism and Glucose and Fatty Acid Disposal in Muscle Cells. J Cell Physiol 231(3): 708-718.

  7. Lopez-Mejia, I. C. and Fajas, L. (2015). Cell cycle regulation of mitochondrial function. Curr Opin Cell Biol 33: 19-25.

  8. Escote, X. and Fajas, L. (2015). Metabolic adaptation to cancer growth: from the cell to the organism. Cancer Lett 356(2 Pt A): 171-175.

  9. Lopez-Royuela, N., Rathore, M. G., Allende-Vega, N., Annicotte, J. S., Fajas, L., Ramachandran, B., Gulick, T. and Villalba, M. (2014). Extracellular-signal-regulated kinase 5 modulates the antioxidant response by transcriptionally controlling Sirtuin 1 expression in leukemic cells. Int J Biochem Cell Biol 53: 253-261.

  10. Lopez-Mejia, I. C., de Toledo, M., Chavey, C., Lapasset, L., Cavelier, P., Lopez-Herrera, C., Chebli, K., Fort, P., Beranger, G., Fajas, L., Amri, E. Z., Casas, F. and Tazi, J. (2014). Antagonistic functions of LMNA isoforms in energy expenditure and lifespan. EMBO Rep 15(5): 529-539.

  11. Bertrand, C., Blanchet, E., Pessemesse, L., Annicotte, J. S., Feillet-Coudray, C., Chabi, B., Levin, J., Fajas, L., Cabello, G., Wrutniak-Cabello, C. and Casas, F. (2013). Mice lacking the p43 mitochondrial T3 receptor become glucose intolerant and insulin resistant during aging. PLoS One 8(9): e75111.

  12. Fajas, L. (2013). Metabolic control in cancer cells. Ann Endocrinol (Paris) 74(2): 71-73.

  13. Fajas, L. (2013). Re-thinking cell cycle regulators: the cross-talk with metabolism. Front Oncol 3: 4.

  14. Fritz, V., Benfodda, Z., Henriquet, C., Hure, S., Cristol, J. P., Michel, F., Carbonneau, M. A., Casas, F. and Fajas, L. (2013). Metabolic intervention on lipid synthesis converging pathways abrogates prostate cancer growth. Oncogene 32(42): 5101-5110.

  15. Blanchet, E., Annicotte, J. S., Pradelli, L. A., Hugon, G., Matecki, S., Mornet, D., Rivier, F. and Fajas, L. (2012). E2F transcription factor-1 deficiency reduces pathophysiology in the mouse model of Duchenne muscular dystrophy through increased muscle oxidative metabolism. Hum Mol Genet 21(17): 3910-3917.

  16. Docquier, A., Augereau, P., Lapierre, M., Harmand, P. O., Badia, E., Annicotte, J. S., Fajas, L. and Cavailles, V. (2012). The RIP140 gene is a transcriptional target of E2F1. PLoS One 7(5): e35839.

  17. Panasyuk, G., Espeillac, C., Chauvin, C., Pradelli, L. A., Horie, Y., Suzuki, A., Annicotte, J. S., Fajas, L., Foretz, M., Verdeguer, F., Pontoglio, M., Ferre, P., Scoazec, J. Y., Birnbaum, M. J., Ricci, J. E. and Pende, M. (2012). PPARgamma contributes to PKM2 and HK2 expression in fatty liver. Nat Commun 3: 672.

  18. Blanchet, E., Bertrand, C., Annicotte, J. S., Schlernitzauer, A., Pessemesse, L., Levin, J., Fouret, G., Feillet-Coudray, C., Bonafos, B., Fajas, L., Cabello, G., Wrutniak-Cabello, C. and Casas, F. (2012). Mitochondrial T3 receptor p43 regulates insulin secretion and glucose homeostasis. FASEB J 26(1): 40-50.

  19. Fajas, L. and Annicotte, J. S. (2011). E2F1 at the crossroad of proliferation and oxidative metabolism. Cell Cycle 10(24): 4193-4194.

  20. Blanchet, E., Annicotte, J. S., Lagarrigue, S., Aguilar, V., Clape, C., Chavey, C., Fritz, V., Casas, F., Apparailly, F., Auwerx, J. and Fajas, L. (2011). E2F transcription factor-1 regulates oxidative metabolism. Nat Cell Biol 13(9): 1146-1152.

  21. Lagarrigue, S., Blanchet, E., Annicotte, J. S. and Fajas, L. (2011). [Emerging key role of cell cycle regulators in cell metabolism]. Med Sci (Paris) 27(5): 508-513.

  22. Botton, T., Puissant, A., Cheli, Y., Tomic, T., Giuliano, S., Fajas, L., Deckert, M., Ortonne, J. P., Bertolotto, C., Tartare-Deckert, S., Ballotti, R. and Rocchi, S. (2011). Ciglitazone negatively regulates CXCL1 signaling through MITF to suppress melanoma growth. Cell Death Differ 18(1): 109-121.

  23. Fajas, L., Blanchet, E. and Annicotte, J. S. (2010). The CDK4-pRB-E2F1 pathway : A new modulator of insulin secretion. Islets 2(1): 51-53.

  24. Aguilar, V., Annicotte, J. S., Escote, X., Vendrell, J., Langin, D. and Fajas, L. (2010). Cyclin G2 regulates adipogenesis through PPAR gamma coactivation. Endocrinology 151(11): 5247-5254.

  25. Aguilar, V. and Fajas, L. (2010). Cycling through metabolism. EMBO Mol Med 2(9): 338-348.

  26. Fritz, V., Benfodda, Z., Rodier, G., Henriquet, C., Iborra, F., Avances, C., Allory, Y., de la Taille, A., Culine, S., Blancou, H., Cristol, J. P., Michel, F., Sardet, C. and Fajas, L. (2010). Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice. Mol Cancer Ther 9(6): 1740-1754.

  27. Fritz, V. and Fajas, L. (2010). Metabolism and proliferation share common regulatory pathways in cancer cells. Oncogene 29(31): 4369-4377.

  28. Fajas, L., Blanchet, E. and Annicotte, J. S. (2010). CDK4, pRB and E2F1: connected to insulin. Cell Div 5(1): 6.

  29. Ruzzin, J., Petersen, R., Meugnier, E., Madsen, L., Lock, E. J., Lillefosse, H., Ma, T., Pesenti, S., Sonne, S. B., Marstrand, T. T., Malde, M. K., Du, Z. Y., Chavey, C., Fajas, L., Lundebye, A. K., Brand, C. L., Vidal, H., Kristiansen, K. and Froyland, L. (2010). Persistent organic pollutant exposure leads to insulin resistance syndrome. Environ Health Perspect 118(4): 465-471.

Protocols by Luis Fajas
  1. Determination of the Glycolysis and Lipogenesis in Culture of Hepatocytes