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Ana S. H. Costa

Education

Ph.D. from 4 year Ph.D. programme in Veterinary Sciences, Faculty of Veterinary Medicine, University of Lisbon, Portugal

Current position

Research Associate in MRC Cancer Unit, University of Cambridge, UK 

Publications

  1. Sciacovelli, M., Goncalves, E., Johnson, T. I., Zecchini, V. R., da Costa, A. S., Gaude, E., Drubbel, A. V., Theobald, S. J., Abbo, S. R., Tran, M. G., Rajeeve, V., Cardaci, S., Foster, S., Yun, H., Cutillas, P., Warren, A., Gnanapragasam, V., Gottlieb, E., Franze, K., Huntly, B., Maher, E. R., Maxwell, P. H., Saez-Rodriguez, J. and Frezza, C. (2016). Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition. Nature 537(7621): 544-547.

  2. Koziol, M. J., Bradshaw, C. R., Allen, G. E., Costa, A. S., Frezza, C. and Gurdon, J. B. (2016). Identification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modifications. Nat Struct Mol Biol 23(1): 24-30.

  3. Matheson, N. J., Sumner, J., Wals, K., Rapiteanu, R., Weekes, M. P., Vigan, R., Weinelt, J., Schindler, M., Antrobus, R., Costa, A. S., Frezza, C., Clish, C. B., Neil, S. J. and Lehner, P. J. (2015). Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef. Cell Host Microbe 18(4): 409-423.

  4. Costa, P., Simoes, J. A., Costa, A. S., Lemos, J. P., Navas, D., Hocquette, J. F., Calkins, C. R. and Bessa, R. J. (2015). Repercussions of growth path on carcass characteristics, meat colour and shear force in Alentejana bulls. Animal 9(8): 1414-1422.

  5. Chouchani, E. T., Pell, V. R., Gaude, E., Aksentijevic, D., Sundier, S. Y., Robb, E. L., Logan, A., Nadtochiy, S. M., Ord, E. N., Smith, A. C., Eyassu, F., Shirley, R., Hu, C. H., Dare, A. J., James, A. M., Rogatti, S., Hartley, R. C., Eaton, S., Costa, A. S., Brookes, P. S., Davidson, S. M., Duchen, M. R., Saeb-Parsy, K., Shattock, M. J., Robinson, A. J., Work, L. M., Frezza, C., Krieg, T. and Murphy, M. P. (2014). Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature 515(7527): 431-435.

  6. Mera, P., Mir, J. F., Fabrias, G., Casas, J., Costa, A. S., Malandrino, M. I., Fernandez-Lopez, J. A., Remesar, X., Gao, S., Chohnan, S., Rodriguez-Pena, M. S., Petry, H., Asins, G., Hegardt, F. G., Herrero, L. and Serra, D. (2014). Long-term increased carnitine palmitoyltransferase 1A expression in ventromedial hypotalamus causes hyperphagia and alters the hypothalamic lipidomic profile. PLoS One 9(5): e97195.

  7. da Costa, A. S., Bessa, R. J., Pires, V. M., Rolo, E. A., Pinto, R. M., Andrade Fontes, C. M. and Prates, J. A. (2014). Is hepatic lipid metabolism of beef cattle influenced by breed and dietary silage level? BMC Vet Res 10: 65.

  8. Lopes, P. A., Costa, A. S., Costa, P., Pires, V. M., Madeira, M. S., Achega, F., Pinto, R. M. and Prates, J. A. (2014). Contrasting cellularity on fat deposition in the subcutaneous adipose tissue and longissimus lumborum muscle from lean and fat pigs under dietary protein reduction. Animal 8(4): 629-637.

  9. da Costa, A. S., Pires, V. M., Fontes, C. M. and Mestre Prates, J. A. (2013). Expression of genes controlling fat deposition in two genetically diverse beef cattle breeds fed high or low silage diets. BMC Vet Res 9: 118.

  10. Costa, A. S., Silva, M. P., Alfaia, C. P., Pires, V. M., Fontes, C. M., Bessa, R. J. and Prates, J. A. (2013). Genetic background and diet impact beef fatty acid composition and stearoyl-CoA desaturase mRNA expression. Lipids 48(4): 369-381.

  11. Costa, A. S., Costa, P., Bessa, R. J., Lemos, J. P., Simoes, J. A., Santos-Silva, J., Fontes, C. M. and Prates, J. A. (2013). Carcass fat partitioning and meat quality of Alentejana and Barrosa young bulls fed high or low maize silage diets. Meat Sci 93(3): 405-412.

  12. Madeira, M. S., Pires, V. M., Alfaia, C. M., Costa, A. S., Luxton, R., Doran, O., Bessa, R. J. and Prates, J. A. (2013). Differential effects of reduced protein diets on fatty acid composition and gene expression in muscle and subcutaneous adipose tissue of Alentejana purebred and Large White x Landrace x Pietrain crossbred pigs. Br J Nutr 110(2): 216-229.

  13. Pestana, J. M., Costa, A. S. H., Alfaia, C. M., Costa, P., Martins, S. V., Alves, S. P., Bessa, R. J. B. and Prates, J. A. M. (2012). Lipid composition and nutritional quality of intramuscular fat in Charneca-PDO beef. European Food Research and Technology 234(2): pp 187-196.

  14. Pestana, J. M., Costa, A. S., Alves, S. P., Martins, S. V., Alfaia, C. M., Bessa, R. J. and Prates, J. A. (2012). Seasonal changes and muscle type effect on the nutritional quality of intramuscular fat in Mirandesa-PDO veal. Meat Sci 90(3): 819-827.

  15. Costa, A. S., Lopes, P. A., Estevao, M., Martins, S. V., Alves, S. P., Pinto, R. M., Pissarra, H., Correia, J. J., Pinho, M., Fontes, C. M. and Prates, J. A. (2012). Contrasting cellularity and fatty acid composition in fat depots from Alentejana and Barrosa bovine breeds fed high and low forage diets. Int J Biol Sci 8(2): 214-227.

  16. Costa, P., Lemos, J. P., Lopes, P. A., Alfaia, C. M., Costa, A. S., Bessa, R. J. and Prates, J. A. (2012). Effect of low- and high-forage diets on meat quality and fatty acid composition of Alentejana and Barrosa beef breeds. Animal 6(7): 1187-1197.

  17. Pestana, J. M., Costa, A. S., Martins, S. V., Alfaia, C. M., Alves, S. P., Lopes, P. A., Bessa, R. J. and Prates, J. A. (2012). Effect of slaughter season and muscle type on the fatty acid composition, including conjugated linoleic acid isomers, and nutritional value of intramuscular fat in organic beef. J Sci Food Agric 92(12): 2428-2435.

  18. Martins, A. P., Lopes, P. A., Costa, A. S., Martins, S. V., Santos, N. C., Prates, J. A., Moura, T. F. and Soveral, G. (2011). Differential mesenteric fat deposition in bovines fed on silage or concentrate is independent of glycerol membrane permeability. Animal 5(12): 1949-1956.

  19. Ferreira-Dias, G., Costa, A. S., Mateus, L., Korzekwa, A. J., Galvao, A., Redmer, D. A., Lukasik, K., Szostek, A. Z., Woclawek-Potocka, I. and Skarzynski, D. J. (2011). Nitric oxide stimulates progesterone and prostaglandin E2 secretion as well as angiogenic activity in the equine corpus luteum. Domest Anim Endocrinol 40(1): 1-9.

  20. Alfaia, C. M., Alves, S. P., Lopes, A. F., Fernandes, M. J., Costa, A. S., Fontes, C. M., Castro, M. L., Bessa, R. J. and Prates, J. A. (2010). Effect of cooking methods on fatty acids, conjugated isomers of linoleic acid and nutritional quality of beef intramuscular fat. Meat Sci 84(4): 769-777.

  21. Pestana, J. M., Martins, S. I. V., Alfaia, C. M. M., Lopes, P. A., Costa, A. S. H., Bessa, R. J. B., Castro, M. L. F. and Prates, J. A. M. (2009). Content and distribution of conjugated linoleic acid isomers in bovine milk, cheese and butter from Azores. Dairy Science and Technology.

  22. Alfaia, C. P. M., Alves, S. P., Martins, S. I. V., Costa, A. S. H., Fontes, C. M. G. A., Lemos, J. P. C., Bessa, R. J. B. and Prates, J. A. M. (2009). Effect of the feeding system on intramuscular fatty acids and conjugated linoleic acid isomers of beef cattle, with emphasis on their nutritional value and discriminatory ability. Food Chemistry.

  23. Roberto da Costa, R. P., Costa, A. S., Korzekwa, A. J., Platek, R., Siemieniuch, M., Galvao, A., Redmer, D. A., Silva, J. R., Skarzynski, D. J. and Ferreira-Dias, G. (2008). Actions of a nitric oxide donor on prostaglandin production and angiogenic activity in the equine endometrium. Reprod Fertil Dev 20(6): 674-683.

  24. Ferreira-Dias, G., Mateus, L., Costa, A. S., Sola, S., Ramalho, R. M., Castro, R. E. and Rodrigues, C. M. (2007). Progesterone and caspase-3 activation in equine cyclic corpora lutea. Reprod Domest Anim 42(4): 380-386.

  25. Ferreira-Dias, G., Costa, A. S., Mateus, L., Korzekwa, A., Redmer, D. A. and Skarzynski, D. J. (2006). Proliferative processes within the equine corpus luteum may depend on paracrine progesterone actions. J Physiol Pharmacol 57 Suppl 8: 139-151.

  26. Costa, A. S., Mateus, L., Redmer, D., Skarzynski, D. J. and Ferreira-Dias, G. (2006). Is progesterone a paracrine regulator of endothelial cell proliferation in equine corpora lutea? Reproduction in Domestic Animals 41(4): 361.

Protocols by Ana S. H. Costa
  1. Identification of Methylated Deoxyadenosines in Genomic DNA by dA6m DNA Immunoprecipitation