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Bruce Beutler

Education

M.D., Pritzker School of Medicine, University of Chicago, Chicago, Illinois, U.S.A., 1981

Current position

Regental Professor and Director, Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, Texas, U.S.A.

Publications (since 2012)

  1. Beutler, B. (2016). Finding New Components of the Mammalian Immune System. Rambam Maimonides Med J 7(3).

  2. Wang, J. Q., Beutler, B., Goodnow, C. C. and Horikawa, K. (2016). Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of MYD88L265P plasmablasts in vivo. Blood 128(12): 1604-1608.

  3. Siggs, O. M., Stockenhuber, A., Deobagkar-Lele, M., Bull, K. R., Crockford, T. L., Kingston, B. L., Crawford, G., Anzilotti, C., Steeples, V., Ghaffari, S., Czibik, G., Bellahcene, M., Watkins, H., Ashrafian, H., Davies, B., Woods, A., Carling, D., Yavari, A., Beutler, B. and Cornall, R. J. (2016). Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity. Proc Natl Acad Sci U S A 113(26): E3706-3715.

  4. Morin, M. D., Wang, Y., Jones, B. T., Su, L., Surakattula, M. M., Berger, M., Huang, H., Beutler, E. K., Zhang, H., Beutler, B. and Boger, D. L. (2016). Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists. J Med Chem 59(10): 4812-4830.

  5. Pedersen, G. K., Adori, M., Stark, J. M., Khoenkhoen, S., Arnold, C., Beutler, B. and Karlsson Hedestam, G. B. (2016). Heterozygous Mutation in IkappaBNS Leads to Reduced Levels of Natural IgM Antibodies and Impaired Responses to T-Independent Type 2 Antigens. Front Immunol 7: 65.

  6. Wang, Y., Su, L., Morin, M. D., Jones, B. T., Whitby, L. R., Surakattula, M. M., Huang, H., Shi, H., Choi, J. H., Wang, K. W., Moresco, E. M., Berger, M., Zhan, X., Zhang, H., Boger, D. L. and Beutler, B. (2016). TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS. Proc Natl Acad Sci U S A 113(7): E884-893.

  7. Shi, H., Wang, Y., Li, X., Zhan, X., Tang, M., Fina, M., Su, L., Pratt, D., Bu, C. H., Hildebrand, S., Lyon, S., Scott, L., Quan, J., Sun, Q., Russell, J., Arnett, S., Jurek, P., Chen, D., Kravchenko, V. V., Mathison, J. C., Moresco, E. M., Monson, N. L., Ulevitch, R. J. and Beutler, B. (2016). NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component. Nat Immunol 17(3): 250-258.

  8. Beutler, B. and Thaiss, C. A. (2015). Q&A: Chance encounters. Nature 526(7574): S59-60.

  9. Simon, M. M., Moresco, E. M., Bull, K. R., Kumar, S., Mallon, A. M., Beutler, B. and Potter, P. K. (2015). Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing. Mamm Genome 26(9-10): 486-500.

  10. Siggs, O. M., Popkin, D. L., Krebs, P., Li, X., Tang, M., Zhan, X., Zeng, M., Lin, P., Xia, Y., Oldstone, M. B., Cornall, R. J. and Beutler, B. (2015). Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection. Proc Natl Acad Sci U S A 112(42): E5706-5714.

  11. Miosge, L. A., Field, M. A., Sontani, Y., Cho, V., Johnson, S., Palkova, A., Balakishnan, B., Liang, R., Zhang, Y., Lyon, S., Beutler, B., Whittle, B., Bertram, E. M., Enders, A., Goodnow, C. C. and Andrews, T. D. (2015). Comparison of predicted and actual consequences of missense mutations. Proc Natl Acad Sci U S A 112(37): E5189-5198.

  12. Mager, L. F., Riether, C., Schurch, C. M., Banz, Y., Wasmer, M. H., Stuber, R., Theocharides, A. P., Li, X., Xia, Y., Saito, H., Nakae, S., Baerlocher, G. M., Manz, M. G., McCoy, K. D., Macpherson, A. J., Ochsenbein, A. F., Beutler, B. and Krebs, P. (2015). IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms. J Clin Invest 125(7): 2579-2591.

  13. von Hertzen, L., Beutler, B., Bienenstock, J., Blaser, M., Cani, P. D., Eriksson, J., Farkkila, M., Haahtela, T., Hanski, I., Jenmalm, M. C., Kere, J., Knip, M., Kontula, K., Koskenvuo, M., Ling, C., Mandrup-Poulsen, T., von Mutius, E., Makela, M. J., Paunio, T., Pershagen, G., Renz, H., Rook, G., Saarela, M., Vaarala, O., Veldhoen, M. and de Vos, W. M. (2015). Helsinki alert of biodiversity and health. Ann Med 47(3): 218-225.

  14. Wang, T., Zhan, X., Bu, C. H., Lyon, S., Pratt, D., Hildebrand, S., Choi, J. H., Zhang, Z., Zeng, M., Wang, K. W., Turer, E., Chen, Z., Zhang, D., Yue, T., Wang, Y., Shi, H., Wang, J., Sun, L., SoRelle, J., McAlpine, W., Hutchins, N., Zhan, X., Fina, M., Gobert, R., Quan, J., Kreutzer, M., Arnett, S., Hawkins, K., Leach, A., Tate, C., Daniel, C., Reyna, C., Prince, L., Davis, S., Purrington, J., Bearden, R., Weatherly, J., White, D., Russell, J., Sun, Q., Tang, M., Li, X., Scott, L., Moresco, E. M., McInerney, G. M., Karlsson Hedestam, G. B., Xie, Y. and Beutler, B. (2015). Real-time resolution of point mutations that cause phenovariance in mice. Proc Natl Acad Sci U S A 112(5): E440-449.

  15. Dosenovic, P., Adori, M., Adams, W. C., Pedersen, G. K., Soldemo, M., Beutler, B. and Karlsson Hedestam, G. B. (2015). Slc15a4 function is required for intact class switch recombination to IgG2c in response to TLR9 stimulation. Immunol Cell Biol 93(2): 136-146.

  16. Jimenez-Dalmaroni, M. J., Radcliffe, C. M., Harvey, D. J., Wormald, M. R., Verdino, P., Ainge, G. D., Larsen, D. S., Painter, G. F., Ulevitch, R., Beutler, B., Rudd, P. M., Dwek, R. A. and Wilson, I. A. (2015). Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids. Innate Immun 21(2): 175-193.

  17. Zeng, M., Hu, Z., Shi, X., Li, X., Zhan, X., Li, X. D., Wang, J., Choi, J. H., Wang, K. W., Purrington, T., Tang, M., Fina, M., DeBerardinis, R. J., Moresco, E. M., Pedersen, G., McInerney, G. M., Karlsson Hedestam, G. B., Chen, Z. J. and Beutler, B. (2014). MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses. Science 346(6216): 1486-1492.

  18. Pedersen, G. K., Adori, M., Khoenkhoen, S., Dosenovic, P., Beutler, B. and Karlsson Hedestam, G. B. (2014). B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IkappaBNS. Proc Natl Acad Sci U S A 111(39): E4119-4126.

  19. Rommelaere, S., Millet, V., Vu Manh, T. P., Gensollen, T., Andreoletti, P., Cherkaoui-Malki, M., Bourges, C., Escaliere, B., Du, X., Xia, Y., Imbert, J., Beutler, B., Kanai, Y., Malissen, B., Malissen, M., Tailleux, A., Staels, B., Galland, F. and Naquet, P. (2014). Sox17 regulates liver lipid metabolism and adaptation to fasting. PLoS One 9(8): e104925.

  20. Colak, E., Leslie, A., Zausmer, K., Khatamzas, E., Kubarenko, A. V., Pichulik, T., Klimosch, S. N., Mayer, A., Siggs, O., Hector, A., Fischer, R., Klesser, B., Rautanen, A., Frank, M., Hill, A. V., Manoury, B., Beutler, B., Hartl, D., Simmons, A. and Weber, A. N. (2014). RNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events. J Immunol 192(12): 5963-5973.

  21. Chen, Z., Holland, W., Shelton, J. M., Ali, A., Zhan, X., Won, S., Tomisato, W., Liu, C., Li, X., Moresco, E. M. and Beutler, B. (2014). Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling. Proc Natl Acad Sci U S A 111(20): 7367-7372.

  22. Wang, J. Q., Jeelall, Y. S., Beutler, B., Horikawa, K. and Goodnow, C. C. (2014). Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance. J Exp Med 211(3): 413-426.

  23. Garrison, S. R., Weyer, A. D., Barabas, M. E., Beutler, B. A. and Stucky, C. L. (2014). A gain-of-function voltage-gated sodium channel 1.8 mutation drives intense hyperexcitability of A- and C-fiber neurons. Pain 155(5): 896-905.

  24. Tabeta, K., Hoebe, K., Janssen, E. M., Xia, Y. and Beutler, B. (2013). Respond to "No antigen-presentation defect in Unc93b1(3d/3d) (3d) mice". Nat Immunol 14(11): 1102-1103.

  25. Moresco, E. M., Li, X. and Beutler, B. (2013). Going forward with genetics: recent technological advances and forward genetics in mice. Am J Pathol 182(5): 1462-1473.

  26. Koh, Y. T., Scatizzi, J. C., Gahan, J. D., Lawson, B. R., Baccala, R., Pollard, K. M., Beutler, B. A., Theofilopoulos, A. N. and Kono, D. H. (2013). Role of nucleic acid-sensing TLRs in diverse autoantibody specificities and anti-nuclear antibody-producing B cells. J Immunol 190(10): 4982-4990.

  27. Teh, C. E., Horikawa, K., Arnold, C. N., Beutler, B., Kucharska, E. M., Vinuesa, C. G., Bertram, E. M., Goodnow, C. C. and Enders, A. (2013). Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation. Genes Immun 14(4): 223-233.

  28. Bull, K. R., Rimmer, A. J., Siggs, O. M., Miosge, L. A., Roots, C. M., Enders, A., Bertram, E. M., Crockford, T. L., Whittle, B., Potter, P. K., Simon, M. M., Mallon, A. M., Brown, S. D., Beutler, B., Goodnow, C. C., Lunter, G. and Cornall, R. J. (2013). Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations. PLoS Genet 9(1): e1003219.

  29. Baccala, R., Gonzalez-Quintial, R., Blasius, A. L., Rimann, I., Ozato, K., Kono, D. H., Beutler, B. and Theofilopoulos, A. N. (2013). Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus. Proc Natl Acad Sci U S A 110(8): 2940-2945.

  30. Siggs, O. M., Cruite, J. T., Du, X., Rutschmann, S., Masliah, E., Beutler, B. and Oldstone, M. B. (2012). Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease. Proc Natl Acad Sci U S A 109(34): 13733-13738.

  31. Siggs, O. M., Xiao, N., Wang, Y., Shi, H., Tomisato, W., Li, X., Xia, Y. and Beutler, B. (2012). iRhom2 is required for the secretion of mouse TNFalpha. Blood 119(24): 5769-5771.

  32. Rutschmann, S., Crozat, K., Li, X., Du, X., Hanselman, J. C., Shigeoka, A. A., Brandl, K., Popkin, D. L., McKay, D. B., Xia, Y., Moresco, E. M. and Beutler, B. (2012). Hypopigmentation and maternal-zygotic embryonic lethality caused by a hypomorphic mbtps1 mutation in mice. G3 (Bethesda) 2(4): 499-504.

  33. Narni-Mancinelli, E., Jaeger, B. N., Bernat, C., Fenis, A., Kung, S., De Gassart, A., Mahmood, S., Gut, M., Heath, S. C., Estelle, J., Bertosio, E., Vely, F., Gastinel, L. N., Beutler, B., Malissen, B., Malissen, M., Gut, I. G., Vivier, E. and Ugolini, S. (2012). Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses. Science 335(6066): 344-348.

  34. Brandl, K., Tomisato, W. and Beutler, B. (2012). Inflammatory bowel disease and ADAM17 deletion. N Engl J Med 366(2): 190; author reply 190.

  35. Siggs, O. M., Li, X., Xia, Y. and Beutler, B. (2012). ZBTB1 is a determinant of lymphoid development. J Exp Med 209(1): 19-27.

  36. Won, S., Eidenschenk, C., Arnold, C. N., Siggs, O. M., Sun, L., Brandl, K., Mullen, T. M., Nemerow, G. R., Moresco, E. M. and Beutler, B. (2012). Increased susceptibility to DNA virus infection in mice with a GCN2 mutation. J Virol 86(3): 1802-1808.

Protocols by Bruce Beutler
  1. Reconstruction of the Mouse Inflammasome System in HEK293T Cells