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I-hsin Su

Education

Ph.D., Institute for Genetics, University of Cologne, Germany, 2001

Current position

Assistant Professor, School of Biological Science, College of Science, Nanyang Technological University, Singapore

Publications

  1. Loh, J. T. and Su, I. H. (2016). Post-translational modification-regulated leukocyte adhesion and migration. Oncotarget 7(24): 37347-37360.

  2. Gunawan, M., Venkatesan, N., Loh, J. T., Wong, J. F., Berger, H., Neo, W. H., Li, L. Y., La Win, M. K., Yau, Y. H., Guo, T., See, P. C., Yamazaki, S., Chin, K. C., Gingras, A. R., Shochat, S. G., Ng, L. G., Sze, S. K., Ginhoux, F. and Su, I. H. (2015). The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin. Nat Immunol 16(5): 505-516.

  3. Neo, W. H., Lim, J. F., Grumont, R., Gerondakis, S. and Su, I. H. (2014). c-Rel regulates Ezh2 expression in activated lymphocytes and malignant lymphoid cells. J Biol Chem 289(46): 31693-31707.

  4. Neo, W. H., Yap, K., Lee, S. H., Looi, L. S., Khandelia, P., Neo, S. X., Makeyev, E. V. and Su, I. H. (2014). MicroRNA miR-124 controls the choice between neuronal and astrocyte differentiation by fine-tuning Ezh2 expression. J Biol Chem 289(30): 20788-20801.

  5. Caganova, M., Carrisi, C., Varano, G., Mainoldi, F., Zanardi, F., Germain, P. L., George, L., Alberghini, F., Ferrarini, L., Talukder, A. K., Ponzoni, M., Testa, G., Nojima, T., Doglioni, C., Kitamura, D., Toellner, K. M., Su, I. H. and Casola, S. (2013). Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis. J Clin Invest 123(12): 5009-5022.

  6. Chan, Y. S., Goke, J., Lu, X., Venkatesan, N., Feng, B., Su, I. H. and Ng, H. H. (2013). A PRC2-dependent repressive role of PRDM14 in human embryonic stem cells and induced pluripotent stem cell reprogramming. Stem Cells 31(4): 682-692.

  7. Wyngaarden, L. A., Delgado-Olguin, P., Su, I. H., Bruneau, B. G. and Hopyan, S. (2011). Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb. Development 138(17): 3759-3767.

  8. Wang, L., Jin, Q., Lee, J. E., Su, I. H. and Ge, K. (2010). Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis. Proc Natl Acad Sci U S A 107(16): 7317-7322.

  9. Xu, S., Huo, J., Gunawan, M., Su, I. H. and Lam, K. P. (2009). Activated dectin-1 localizes to lipid raft microdomains for signaling and activation of phagocytosis and cytokine production in dendritic cells. J Biol Chem 284(33): 22005-22011.

  10. Chen, H., Gu, X., Su, I. H., Bottino, R., Contreras, J. L., Tarakhovsky, A. and Kim, S. K. (2009). Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. Genes Dev 23(8): 975-985.

  11. Ezhkova, E., Pasolli, H. A., Parker, J. S., Stokes, N., Su, I. H., Hannon, G., Tarakhovsky, A. and Fuchs, E. (2009). Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell 136(6): 1122-1135.

  12. Su, I. H. and Tarakhovsky, A. (2006). Lysine methylation and 'signaling memory'. Curr Opin Immunol 18(2): 152-157.

  13. Su, I. H., Dobenecker, M. W., Dickinson, E., Oser, M., Basavaraj, A., Marqueron, R., Viale, A., Reinberg, D., Wulfing, C. and Tarakhovsky, A. (2005). Polycomb group protein ezh2 controls actin polymerization and cell signaling. Cell 121(3): 425-436.

  14. Su, I. H. and Tarakhovsky, A. (2005). Epigenetic control of B cell differentiation. Semin Immunol 17(2): 167-172.

  15. Erhardt, S., Su, I. H., Schneider, R., Barton, S., Bannister, A. J., Perez-Burgos, L., Jenuwein, T., Kouzarides, T., Tarakhovsky, A. and Surani, M. A. (2003). Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development 130(18): 4235-4248.

  16. Saijo, K., Schmedt, C., Su, I. H., Karasuyama, H., Lowell, C. A., Reth, M., Adachi, T., Patke, A., Santana, A. and Tarakhovsky, A. (2003). Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat Immunol 4(3): 274-279.

  17. Su, I. H., Basavaraj, A., Krutchinsky, A. N., Hobert, O., Ullrich, A., Chait, B. T. and Tarakhovsky, A. (2003). Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat Immunol 4(2): 124-131.

  18. Yokoyama, K., Su Ih, I. H., Tezuka, T., Yasuda, T., Mikoshiba, K., Tarakhovsky, A. and Yamamoto, T. (2002). BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor. EMBO J 21(1-2): 83-92.

  19. Ogata, H., Su, I., Miyake, K., Nagai, Y., Akashi, S., Mecklenbrauker, I., Rajewsky, K., Kimoto, M. and Tarakhovsky, A. (2000). The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. J Exp Med 192(1): 23-29.

  20. Su, I. and Tarakhovsky, A. (2000). B-1 cells: orthodox or conformist? Curr Opin Immunol 12(2): 191-194.

  21. Texido, G., Su, I. H., Mecklenbrauker, I., Saijo, K., Malek, S. N., Desiderio, S., Rajewsky, K. and Tarakhovsky, A. (2000). The B-cell-specific Src-family kinase Blk is dispensable for B-cell development and activation. Mol Cell Biol 20(4): 1227-1233.

  22. Chan, V. W., Mecklenbrauker, I., Su, I., Texido, G., Leitges, M., Carsetti, R., Lowell, C. A., Rajewsky, K., Miyake, K. and Tarakhovsky, A. (1998). The molecular mechanism of B cell activation by toll-like receptor protein RP-105. J Exp Med 188(1): 93-101.

Protocols by I-hsin Su
  1. Ear Inflammation and Whole-mount Ear Staining