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Chia-Yang Liu


Ph.D., University of Cincinnati Medical Center (Interdisciplinary Ph.D. Program/Molecular Ophthalmology), 1993

Current position

Associate Professor, School of Optometry, Indiana University at Bloomington

Publications (since 2010)

  1. Liu, C. Y. (2015). Wakayama symposium: role of canonical Notch signaling in conjucntival goblet cell differentiation and dry eye syndrome. BMC Ophthalmol 15 Suppl 1: 152.

  2. Dong, F., Liu, C. Y., Yuan, Y., Zhang, Y., Li, W., Call, M., Zhang, L., Chen, Y., Liu, Z. and Kao, W. W. (2015). Perturbed meibomian gland and tarsal plate morphogenesis by excess TGFalpha in eyelid stroma. Dev Biol 406(2): 147-157.

  3. Zhang, Y., Yeh, L. K., Zhang, S., Call, M., Yuan, Y., Yasunaga, M., Kao, W. W. and Liu, C. Y. (2015). Wnt/beta-catenin signaling modulates corneal epithelium stratification via inhibition of Bmp4 during mouse development. Development 142(19): 3383-3393.Coulson-Thomas, V. J., Chang, S. H., Yeh, L. K., Coulson-Thomas, Y. M., Yamaguchi, Y., Esko, J., Liu, C. Y. and Kao, W. (2015). Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing. Invest Ophthalmol Vis Sci 56(5): 3004-3014.

  4. Mizoguchi, S., Suzuki, K., Zhang, J., Yamanaka, O., Liu, C. Y., Okada, Y., Miyajima, M., Kokado, M., Kao, W. W., Yamada, G. and Saika, S. (2015). Disruption of eyelid and cornea morphogenesis by epithelial beta-catenin gain-of-function. Mol Vis 21: 793-803.

  5. Liu, C. Y. and Kao, W. W. (2015). Corneal Epithelial Wound Healing. Prog Mol Biol Transl Sci 134: 61-71.

  6. Byun, Y. S., Tibrewal, S., Kim, E., Yco, L., Sarkar, J., Ivanir, Y., Liu, C. Y., Sano, C. M. and Jain, S. (2014). Keratocytes derived from spheroid culture of corneal stromal cells resemble tissue resident keratocytes. PLoS One 9(11): e112781.

  7. Yang, D., Sun, Y. Y., Bhaumik, S. K., Li, Y., Baumann, J. M., Lin, X., Zhang, Y., Lin, S. H., Dunn, R. S., Liu, C. Y., Shie, F. S., Lee, Y. H., Wills-Karp, M., Chougnet, C. A., Kallapur, S. G., Lewkowich, I. P., Lindquist, D. M., Murali-Krishna, K. and Kuan, C. Y. (2014). Blocking lymphocyte trafficking with FTY720 prevents inflammation-sensitized hypoxic-ischemic brain injury in newborns. J Neurosci 34(49): 16467-16481.

  8. Meng, Q., Mongan, M., Carreira, V., Kurita, H., Liu, C. Y., Kao, W. W. and Xia, Y. (2014). Eyelid closure in embryogenesis is required for ocular adnexa development. Invest Ophthalmol Vis Sci 55(11): 7652-7661.

  9. McCauley, H. A., Liu, C. Y., Attia, A. C., Wikenheiser-Brokamp, K. A., Zhang, Y., Whitsett, J. A. and Guasch, G. (2014). TGFbeta signaling inhibits goblet cell differentiation via SPDEF in conjunctival epithelium. Development 141(23): 4628-4639.

  10. Feng, L., Li, S. K., Liu, H., Liu, C. Y., LaSance, K., Haque, F., Shu, D. and Guo, P. (2014). Ocular delivery of pRNA nanoparticles: distribution and clearance after subconjunctival injection. Pharm Res 31(4): 1046-1058.

  11. Wu, Y. C., Chen, R. F., Liu, C. Y., Hu, F. R., Huang, C. J. and Wang, I. J. (2014). Knockdown of zebrafish blood vessel epicardial substance results in incomplete retinal lamination. ScientificWorldJournal 2014: 803718.

  12. Yamanaka, O., Yuan, Y., Coulson-Thomas, V. J., Gesteira, T. F., Call, M. K., Zhang, Y., Zhang, J., Chang, S. H., Xie, C., Liu, C. Y., Saika, S., Jester, J. V. and Kao, W. W. (2013). Lumican binds ALK5 to promote epithelium wound healing. PLoS One 8(12): e82730.

  13. Ng, G. Y., Yeh, L. K., Zhang, Y., Liu, H., Feng, G. S., Kao, W. W. and Liu, C. Y. (2013). Role of SH2-containing tyrosine phosphatase Shp2 in mouse corneal epithelial stratification. Invest Ophthalmol Vis Sci 54(13): 7933-7942.

  14. Yuan, Y., Call, M. K., Yuan, Y., Zhang, Y., Fischesser, K., Liu, C. Y. and Kao, W. W. (2013). Dexamethasone induces cross-linked actin networks in trabecular meshwork cells through noncanonical wnt signaling. Invest Ophthalmol Vis Sci 54(10): 6502-6509.

  15. Yuan, Y., Yeh, L. K., Liu, H., Yamanaka, O., Hardie, W. D., Kao, W. W. and Liu, C. Y. (2013). Targeted overexpression of TGF-alpha in the corneal epithelium of adult transgenic mice induces changes in anterior segment morphology and activates noncanonical Wnt signaling. Invest Ophthalmol Vis Sci 54(3): 1829-1837.

  16. Zhang, Y., Lam, O., Nguyen, M. T., Ng, G., Pear, W. S., Ai, W., Wang, I. J., Kao, W. W. and Liu, C. Y. (2013). Mastermind-like transcriptional co-activator-mediated Notch signaling is indispensable for maintaining conjunctival epithelial identity. Development 140(3): 594-605.

  17. Liu, C. Y. (2012). Wakayama Symposium: Notch-FoxL2-alpha-SMA axis in eyelid levator muscle development and congenital blepharophimosis. Ocul Surf 10(4): 221-223.

  18. Wu, Y. C., Liu, C. Y., Chen, Y. H., Chen, R. F., Huang, C. J. and Wang, I. J. (2012). Blood vessel epicardial substance (Bves) regulates epidermal tight junction integrity through atypical protein kinase C. J Biol Chem 287(47): 39887-39897.

  19. Liu, C. Y. and Kao, W. W. (2012). Lumican promotes corneal epithelial wound healing. Methods Mol Biol 836: 285-290.

  20. Liu, H., Zhang, J., Liu, C. Y., Hayashi, Y. and Kao, W. W. (2012). Bone marrow mesenchymal stem cells can differentiate and assume corneal keratocyte phenotype. J Cell Mol Med 16(5): 1114-1124.

  21. Terai, K., Call, M. K., Liu, H., Saika, S., Liu, C. Y., Hayashi, Y., Chikama, T., Zhang, J., Terai, N., Kao, C. W. and Kao, W. W. (2011). Crosstalk between TGF-beta and MAPK signaling during corneal wound healing. Invest Ophthalmol Vis Sci 52(11): 8208-8215.

  22. Zhang, Y., Kao, W. W., Pelosi, E., Schlessinger, D. and Liu, C. Y. (2011). Notch gain of function in mouse periocular mesenchyme downregulates FoxL2 and impairs eyelid levator muscle formation, leading to congenital blepharophimosis. J Cell Sci 124(Pt 15): 2561-2572.

  23. Yeh, J. T., Yeh, L. K., Jung, S. M., Chang, T. J., Wu, H. H., Shiu, T. F., Liu, C. Y., Kao, W. W. and Chu, P. H. (2010). Impaired skin wound healing in lumican-null mice. Br J Dermatol 163(6): 1174-1180.

  24. Nien, C. J., Massei, S., Lin, G., Liu, H., Paugh, J. R., Liu, C. Y., Kao, W. W., Brown, D. J. and Jester, J. V. (2010). The development of meibomian glands in mice. Mol Vis 16: 1132-1140.

  25. Hayashi, Y., Call, M. K., Liu, C. Y., Hayashi, M., Babcock, G., Ohashi, Y. and Kao, W. W. (2010). Monoallelic expression of Krt12 gene during corneal-type epithelium differentiation of limbal stem cells. Invest Ophthalmol Vis Sci 51(9): 4562-4568.

  26. Hayashi, Y., Call, M. K., Chikama, T., Liu, H., Carlson, E. C., Sun, Y., Pearlman, E., Funderburgh, J. L., Babcock, G., Liu, C. Y., Ohashi, Y. and Kao, W. W. (2010). Lumican is required for neutrophil extravasation following corneal injury and wound healing. J Cell Sci 123(Pt 17): 2987-2995.

  27. Wang, I. J., Jhuang, M. C., Chen, Y. H., Yeh, L. K., Liu, C. Y. and Young, T. H. (2010). Chitosan modification of adenovirus to modify transfection efficiency in bovine corneal epithelial cells. PLoS One 5(8): e12085.

  28. Carlson, E. C., Sun, Y., Auletta, J., Kao, W. W., Liu, C. Y., Perez, V. L. and Pearlman, E. (2010). Regulation of corneal inflammation by neutrophil-dependent cleavage of keratan sulfate proteoglycans as a model for breakdown of the chemokine gradient. J Leukoc Biol 88(3): 517-522.

  29. Liu, H., Zhang, J., Liu, C. Y., Wang, I. J., Sieber, M., Chang, J., Jester, J. V. and Kao, W. W. (2010). Cell therapy of congenital corneal diseases with umbilical mesenchymal stem cells: lumican null mice. PLoS One 5(5): e10707.

  30. Yeh, L. K., Liu, C. Y., Kao, W. W., Huang, C. J., Hu, F. R., Chien, C. L. and Wang, I. J. (2010). Knockdown of zebrafish lumican gene (zlum) causes scleral thinning and increased size of scleral coats. J Biol Chem 285(36): 28141-28155.

  31. Tong, Y. C., Chang, S. F., Kao, W. W., Liu, C. Y. and Liaw, J. (2010). Polymeric micelle gene delivery of bcl-xL via eye drop reduced corneal apoptosis following epithelial debridement. J Control Release 147(1): 76-83.

  32. Zhang, Y., Call, M. K., Yeh, L. K., Liu, H., Kochel, T., Wang, I. J., Chu, P. H., Taketo, M. M., Jester, J. V., Kao, W. W. and Liu, C. Y. (2010). Aberrant expression of a beta-catenin gain-of-function mutant induces hyperplastic transformation in the mouse cornea. J Cell Sci 123(Pt 8): 1285-1294.

Protocols by Chia-Yang Liu
  1. Mouse Corneal Stroma Fibroblast Primary Cell Culture