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Charles W. Bourque

Education

Ph.D. in Physiology, McGill University, Canada, 1984

Current position

Professor, Neurology-Neurosurgery and Medicine, McGill University
Associate Member, Physiology, McGill University

Medical Scientist, Medicine (Division of Neurology), Montreal General Hospital

Publications (since 2010)

  1. Djogo, T., Robins, S. C., Schneider, S., Kryzskaya, D., Liu, X., Mingay, A., Gillon, C. J., Kim, J. H., Storch, K. F., Boehm, U., Bourque, C. W., Stroh, T., Dimou, L. and Kokoeva, M. V. (2016). Adult NG2-Glia Are Required for Median Eminence-Mediated Leptin Sensing and Body Weight Control. Cell Metab 23(5): 797-810.

  2. Choe, K. Y., Prager-Khoutorsky, M., Farmer, W. T., Murai, K. K. and Bourque, C. W. (2016). Effects of Salt Loading on the Morphology of Astrocytes in the Ventral Glia Limitans of the Rat Supraoptic Nucleus. J Neuroendocrinol 28(4).

  3. Choe, K. Y., Trudel, E. and Bourque, C. W. (2016). Effects of Salt Loading on the Regulation of Rat Hypothalamic Magnocellular Neurosecretory Cells by Ionotropic GABA and Glycine Receptors. J Neuroendocrinol 28(4).

  4. Farmer, W. T., Abrahamsson, T., Chierzi, S., Lui, C., Zaelzer, C., Jones, E. V., Bally, B. P., Chen, G. G., Theroux, J. F., Peng, J., Bourque, C. W., Charron, F., Ernst, C., Sjostrom, P. J. and Murai, K. K. (2016). Neurons diversify astrocytes in the adult brain through sonic hedgehog signaling. Science 351(6275): 849-854.

  5. Zaelzer, C., Hua, P., Prager-Khoutorsky, M., Ciura, S., Voisin, D. L., Liedtke, W. and Bourque, C. W. (2015). DeltaN-TRPV1: A Molecular Co-detector of Body Temperature and Osmotic Stress. Cell Rep 13(1): 23-30.

  6. Stare, J., Siami, S., Trudel, E., Prager-Khoutorsky, M., Sharshar, T. and Bourque, C. W. (2015). Effects of Peritoneal Sepsis on Rat Central Osmoregulatory Neurons Mediating Thirst and Vasopressin Release. J Neurosci 35(35): 12188-12197.

  7. Prager-Khoutorsky, M. and Bourque, C. W. (2015). Anatomical organization of the rat organum vasculosum laminae terminalis. Am J Physiol Regul Integr Comp Physiol 309(4): R324-337.

  8. Prager-Khoutorsky, M. and Bourque, C. W. (2015). Mechanical basis of osmosensory transduction in magnocellular neurosecretory neurones of the rat supraoptic nucleus. J Neuroendocrinol 27(6): 507-515.

  9. Choe, K. Y., Han, S. Y., Gaub, P., Shell, B., Voisin, D. L., Knapp, B. A., Barker, P. A., Brown, C. H., Cunningham, J. T. and Bourque, C. W. (2015). High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons. Neuron 85(3): 549-560.

  10. Gagnon, A., Walsh, M., Okuda, T., Choe, K. Y., Zaelzer, C. and Bourque, C. W. (2014). Modulation of spike clustering by NMDA receptors and neurotensin in rat supraoptic nucleus neurons. J Physiol 592(19): 4177-4186.

  11. Prager-Khoutorsky, M., Khoutorsky, A. and Bourque, C. W. (2014). Unique interweaved microtubule scaffold mediates osmosensory transduction via physical interaction with TRPV1. Neuron 83(4): 866-878.

  12. Stachniak, T. J., Trudel, E. and Bourque, C. W. (2014). Cell-specific retrograde signals mediate antiparallel effects of angiotensin II on osmoreceptor afferents to vasopressin and oxytocin neurons. Cell Rep 8(2): 355-362.

  13. Robins, S. C., Trudel, E., Rotondi, O., Liu, X., Djogo, T., Kryzskaya, D., Bourque, C. W. and Kokoeva, M. V. (2013). Evidence for NG2-glia derived, adult-born functional neurons in the hypothalamus. PLoS One 8(10): e78236.

  14. Sudbury, J. R. and Bourque, C. W. (2013). Dynamic and permissive roles of TRPV1 and TRPV4 channels for thermosensation in mouse supraoptic magnocellular neurosecretory neurons. J Neurosci 33(43): 17160-17165.

  15. Choe, K. Y., Olson, J. E. and Bourque, C. W. (2012). Taurine release by astrocytes modulates osmosensitive glycine receptor tone and excitability in the adult supraoptic nucleus. J Neurosci 32(36): 12518-12527.

  16. Chierzi, S., Stachniak, T. J., Trudel, E., Bourque, C. W. and Murai, K. K. (2012). Activity maintains structural plasticity of mossy fiber terminals in the hippocampus. Mol Cell Neurosci 50(3-4): 260-271.

  17. Bourque, C. W., Guilak, F. and Liedtke, W. (2012). A TRP that makes us feel hyper. J Physiol 590(8): 1779-1780.

  18. Trudel, E. and Bourque, C. W. (2012). Circadian modulation of osmoregulated firing in rat supraoptic nucleus neurones. J Neuroendocrinol 24(4): 577-586.

  19. Ciura, S., Liedtke, W. and Bourque, C. W. (2011). Hypertonicity sensing in organum vasculosum lamina terminalis neurons: a mechanical process involving TRPV1 but not TRPV4. J Neurosci 31(41): 14669-14676.

  20. Sudbury, J. R., Ciura, S., Sharif-Naeini, R. and Bourque, C. W. (2010). Osmotic and thermal control of magnocellular neurosecretory neurons--role of an N-terminal variant of trpv1. Eur J Neurosci 32(12): 2022-2030.

  21. Zhan, Y., Melian, N. Y., Pantoja, M., Haines, N., Ruohola-Baker, H., Bourque, C. W., Rao, Y. and Carbonetto, S. (2010). Dystroglycan and mitochondrial ribosomal protein L34 regulate differentiation in the Drosophila eye. PLoS One 5(5): e10488.

  22. Trudel, E. and Bourque, C. W. (2010). Central clock excites vasopressin neurons by waking osmosensory afferents during late sleep. Nat Neurosci 13(4): 467-474.

  23. Prager-Khoutorsky, M. and Bourque, C. W. (2010). Osmosensation in vasopressin neurons: changing actin density to optimize function. Trends Neurosci 33(2): 76-83.

Protocols by Charles W. Bourque
  1. Measuring Rat Serum Osmolality by Freezing Point Osmometry