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Roman Hudec

Education

Ph.D. In Biochemistry at the Slovak Technical University, Bratislava, Slovakia 2005

Current position

Senior research fellow at Mayo Clinic, Jacksonville, Florida, USA

Publications

  1. Jantova, S., Mrvova, N., Hudec, R., Sedlak, J., Panik, M. and Milata, V. (2016). Pro-apoptotic effect of new quinolone 7- ethyl 9-ethyl-6-oxo-6,9-dihydro[1,2,5]selenadiazolo [3,4-h]quinoline-7-carboxylate on cervical cancer cell line HeLa alone/with UVA irradiation. Toxicol In Vitro 33: 35-44.

  2. Fiesel, F. C., Ando, M., Hudec, R., Hill, A. R., Castanedes-Casey, M., Caulfield, T. R., Moussaud-Lamodiere, E. L., Stankowski, J. N., Bauer, P. O., Lorenzo-Betancor, O., Ferrer, I., Arbelo, J. M., Siuda, J., Chen, L., Dawson, V. L., Dawson, T. M., Wszolek, Z. K., Ross, O. A., Dickson, D. W. and Springer, W. (2015). (Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation. EMBO Rep 16(9): 1114-1130.

  3. Jantova, S., Hudec, R., Sekretar, S., Kucerak, J. and Melusova, M. (2014). Salvia officinalis L. extract and its new food antioxidant formulations induce apoptosis through mitochondrial/caspase pathway in leukemia L1210 cells. Interdiscip Toxicol 7(3): 146-153.

  4. Hudec, R., Hamada, K. and Mikoshiba, K. (2013). A fluorescence-based assay for the measurement of S-adenosylhomocysteine hydrolase activity in biological samples. Anal Biochem 433(2): 95-101.

  5. Bauer, P. O., Hudec, R., Goswami, A., Kurosawa, M., Matsumoto, G., Mikoshiba, K. and Nukina, N. (2012). ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT. Mol Neurodegener 7: 43.

  6. Bauer, P. O., Hudec, R., Ozaki, S., Okuno, M., Ebisui, E., Mikoshiba, K. and Nukina, N. (2011). Genetic ablation and chemical inhibition of IP3R1 reduce mutant huntingtin aggregation. Biochem Biophys Res Commun 416(1-2): 13-17.

  7. Giacomello, M., Hudec, R. and Lopreiato, R. (2011). Huntington's disease, calcium, and mitochondria. Biofactors 37(3): 206-218.

  8. Costa, V., Giacomello, M., Hudec, R., Lopreiato, R., Ermak, G., Lim, D., Malorni, W., Davies, K. J., Carafoli, E. and Scorrano, L. (2010). Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli. EMBO Mol Med 2(12): 490-503.

  9. Hudec, R., Lakatos, B., Orlicky, J. and Varecka, L. (2004). Reconstitution of the basal calcium transport in resealed human red blood cell ghosts. Biochem Biophys Res Commun 325(4): 1172-1179.

  10. Hudec, R., Lakatos, B., Kaiserova, K., Orlicky, J. and Varecka, L. (2004). Properties of the basal calcium influx in human red blood cells. Biochim Biophys Acta 1661(2): 204-211.

Protocols by Roman Hudec
  1. Non-radioactive in vitro PINK1 Kinase Assays Using Ubiquitin or Parkin as Substrate