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George Kollias


Ph.D. in Molecular Biology, National and Kapodistrian University of Athens, Greece, 1987

Current position

Member of the Academy of Athens
Professor of Physiology, Medical School, National and Kapodistrian University of Athens, Greece
Director, Division of Immunology, BSRC Fleming, Athens, Greece


  1. Koliaraki, V., Pasparakis, M. and Kollias, G. (2015). IKKbeta in intestinal mesenchymal cells promotes initiation of colitis-associated cancer. J Exp Med 212(13): 2235-2251.

  2. Roulis, M., Nikolaou, C., Kotsaki, E., Kaffe, E., Karagianni, N., Koliaraki, V., Salpea, K., Ragoussis, J., Aidinis, V., Martini, E., Becker, C., Herschman, H. R., Vetrano, S., Danese, S. and Kollias, G. (2014). Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis. Proc Natl Acad Sci U S A 111(43): E4658-4667.

  3. Van Hauwermeiren, F., Armaka, M., Karagianni, N., Kranidioti, K., Vandenbroucke, R. E., Loges, S., Van Roy, M., Staelens, J., Puimege, L., Palagani, A., Berghe, W. V., Victoratos, P., Carmeliet, P., Libert, C. and Kollias, G. (2013). Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium. J Clin Invest 123(6): 2590-2603.

  4. Koliaraki, V., Roulis, M. and Kollias, G. (2012). Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis. J Clin Invest 122(11): 4231-4242.

  5. Roulis, M., Armaka, M., Manoloukos, M., Apostolaki, M. and Kollias, G. (2011). Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology. Proc Natl Acad Sci U S A 108(13): 5396-5401.

  6. Tzima, S., Victoratos, P., Kranidioti, K., Alexiou, M. and Kollias, G. (2009). Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production. J Exp Med 206(5): 1167-1179.

  7. Victoratos, P. and Kollias, G. (2009). Induction of autoantibody-mediated spontaneous arthritis critically depends on follicular dendritic cells. Immunity 30(1): 130-142.

  8. Armaka, M., Apostolaki, M., Jacques, P., Kontoyiannis, D. L., Elewaut, D. and Kollias, G. (2008). Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases. J Exp Med 205(2): 331-337.

  9. Victoratos, P., Lagnel, J., Tzima, S., Alimzhanov, M. B., Rajewsky, K., Pasparakis, M. and Kollias, G. (2006). FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses. Immunity 24(1): 65-77.

  10. Xanthoulea, S., Pasparakis, M., Kousteni, S., Brakebusch, C., Wallach, D., Bauer, J., Lassmann, H. and Kollias, G. (2004). Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases. J Exp Med 200(3): 367-376.

  11. Kontoyiannis, D., Boulougouris, G., Manoloukos, M., Armaka, M., Apostolaki, M., Pizarro, T., Kotlyarov, A., Forster, I., Flavell, R., Gaestel, M., Tsichlis, P., Cominelli, F. and Kollias, G. (2002). Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J Exp Med 196(12): 1563-1574.

  12. Kassiotis, G. and Kollias, G. (2001). Uncoupling the proinflammatory from the immunosuppressive properties of tumor necrosis factor (TNF) at the p55 TNF receptor level: implications for pathogenesis and therapy of autoimmune demyelination. J Exp Med 193(4): 427-434.

  13. Kontoyiannis, D., Kotlyarov, A., Carballo, E., Alexopoulou, L., Blackshear, P. J., Gaestel, M., Davis, R., Flavell, R. and Kollias, G. (2001). Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology. EMBO J 20(14): 3760-3770.

  14. Kontoyiannis, D., Pasparakis, M., Pizarro, T. T., Cominelli, F. and Kollias, G. (1999). Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 10(3): 387-398.

  15. Douni, E. and Kollias, G. (1998). A critical role of the p75 tumor necrosis factor receptor (p75TNF-R) in organ inflammation independent of TNF, lymphotoxin alpha, or the p55TNF-R. J Exp Med 188(7): 1343-1352.

  16. Pasparakis, M., Alexopoulou, L., Grell, M., Pfizenmaier, K., Bluethmann, H. and Kollias, G. (1997). Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor. Proc Natl Acad Sci U S A 94(12): 6319-6323.

  17. Alexopoulou, L., Pasparakis, M. and Kollias, G. (1997). A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling. Eur J Immunol 27(10): 2588-2592.

  18. Pasparakis, M., Alexopoulou, L., Episkopou, V. and Kollias, G. (1996). Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J Exp Med 184(4): 1397-1411.

  19. Keffer, J., Probert, L., Cazlaris, H., Georgopoulos, S., Kaslaris, E., Kioussis, D. and Kollias, G. (1991). Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J 10(13): 4025-4031.

  20. Grosveld, F., van Assendelft, G. B., Greaves, D. R. and Kollias, G. (1987). Position-independent, high-level expression of the human beta-globin gene in transgenic mice. Cell 51(6): 975-985.

Protocols by George Kollias
  1. Isolation of Intestinal Mesenchymal Cells from Adult Mice