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Takuji Iwasato


Ph.D. Kyoto University

Current position

Professor, Division of Neurogenetics, National Institute of Genetics
Professor, Department of Genetics, SOKENDAI 

Publications (since 2005)

  1. Iwata, R., Matsukawa, H., Yasuda, K., Mizuno, H., Itohara, S. and Iwasato, T. (2015). Developmental RacGAP alpha2-Chimaerin Signaling Is a Determinant of the Morphological Features of Dendritic Spines in Adulthood. J Neurosci 35(40): 13728-13744.

  2. Suzuki, A., Lee, L. J., Hayashi, Y., Muglia, L., Itohara, S., Erzurumlu, R. S. and Iwasato, T. (2015). Thalamic adenylyl cyclase 1 is required for barrel formation in the somatosensory cortex. Neuroscience 290: 518-529.

  3. Mita, S., de Monasterio-Schrader, P., Funfschilling, U., Kawasaki, T., Mizuno, H., Iwasato, T., Nave, K. A., Werner, H. B. and Hirata, T. (2015). Transcallosal Projections Require Glycoprotein M6-Dependent Neurite Growth and Guidance. Cereb Cortex 25(11): 4111-4125.

  4. Takahashi, A., Lee, R. X., Iwasato, T., Itohara, S., Arima, H., Bettler, B., Miczek, K. A. and Koide, T. (2015). Glutamate input in the dorsal raphe nucleus as a determinant of escalated aggression in male mice. J Neurosci 35(16): 6452-6463.

  5. Iwata, R., Ohi, K., Kobayashi, Y., Masuda, A., Iwama, M., Yasuda, Y., Yamamori, H., Tanaka, M., Hashimoto, R., Itohara, S. and Iwasato, T. (2014). RacGAP alpha2-chimaerin function in development adjusts cognitive ability in adulthood. Cell Rep 8(5): 1257-1264.

  6. Arakawa, H., Suzuki, A., Zhao, S., Tsytsarev, V., Lo, F. S., Hayashi, Y., Itohara, S., Iwasato, T. and Erzurumlu, R. S. (2014). Thalamic NMDA receptor function is necessary for patterning of the thalamocortical somatosensory map and for sensorimotor behaviors. J Neurosci 34(36): 12001-12014.

  7. Mizuno, H., Luo, W., Tarusawa, E., Saito, Y. M., Sato, T., Yoshimura, Y., Itohara, S. and Iwasato, T. (2014). NMDAR-regulated dynamics of layer 4 neuronal dendrites during thalamocortical reorganization in neonates. Neuron 82(2): 365-379.

  8. Borgius, L., Nishimaru, H., Caldeira, V., Kunugise, Y., Low, P., Reig, R., Itohara, S., Iwasato, T. and Kiehn, O. (2014). Spinal glutamatergic neurons defined by EphA4 signaling are essential components of normal locomotor circuits. J Neurosci 34(11): 3841-3853.

  9. Ogiwara, I., Iwasato, T., Miyamoto, H., Iwata, R., Yamagata, T., Mazaki, E., Yanagawa, Y., Tamamaki, N., Hensch, T. K., Itohara, S. and Yamakawa, K. (2013). Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome. Hum Mol Genet 22(23): 4784-4804.

  10. Sadakata, T., Kakegawa, W., Shinoda, Y., Hosono, M., Katoh-Semba, R., Sekine, Y., Sato, Y., Tanaka, M., Iwasato, T., Itohara, S., Furuyama, K., Kawaguchi, Y., Ishizaki, Y., Yuzaki, M. and Furuichi, T. (2013). CAPS1 deficiency perturbs dense-core vesicle trafficking and Golgi structure and reduces presynaptic release probability in the mouse brain. J Neurosci 33(44): 17326-17334.

  11. Hagglund, M., Dougherty, K. J., Borgius, L., Itohara, S., Iwasato, T. and Kiehn, O. (2013). Optogenetic dissection reveals multiple rhythmogenic modules underlying locomotion. Proc Natl Acad Sci U S A 110(28): 11589-11594.

  12. Yamashita, H., Chen, S., Komagata, S., Hishida, R., Iwasato, T., Itohara, S., Yagi, T., Endo, N., Shibata, M. and Shibuki, K. (2012). Restoration of contralateral representation in the mouse somatosensory cortex after crossing nerve transfer. PLoS One 7(4): e35676.

  13. Dhande, O. S., Bhatt, S., Anishchenko, A., Elstrott, J., Iwasato, T., Swindell, E. C., Xu, H. P., Jamrich, M., Itohara, S., Feller, M. B. and Crair, M. C. (2012). Role of adenylate cyclase 1 in retinofugal map development. J Comp Neurol 520(7): 1562-1583.

  14. Tanabe, Y., Hirano, A., Iwasato, T., Itohara, S., Araki, K., Yamaguchi, T., Ichikawa, T., Kumanishi, T., Aizawa, Y., Takahashi, H., Kakita, A. and Nawa, H. (2010). Molecular characterization and gene disruption of a novel zinc-finger protein, HIT-4, expressed in rodent brain. J Neurochem 112(4): 1035-1044.

  15. Takeuchi, S., Yamaki, N., Iwasato, T., Negishi, M. and Katoh, H. (2009). Beta2-chimaerin binds to EphA receptors and regulates cell migration. FEBS Lett 583(8): 1237-1242.

  16. Singer, P., Yee, B. K., Feldon, J., Iwasato, T., Itohara, S., Grampp, T., Prenosil, G., Benke, D., Mohler, H. and Boison, D. (2009). Altered mnemonic functions and resistance to N-METHYL-d-Aspartate receptor antagonism by forebrain conditional knockout of glycine transporter 1. Neuroscience 161(2): 635-654.

  17. Iwasato, T., Inan, M., Kanki, H., Erzurumlu, R. S., Itohara, S. and Crair, M. C. (2008). Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development. J Neurosci 28(23): 5931-5943.

  18. Araya, R., Kudo, M., Kawano, M., Ishii, K., Hashikawa, T., Iwasato, T., Itohara, S., Terasaki, T., Oohira, A., Mishina, Y. and Yamada, M. (2008). BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood-brain-barrier. Mol Cell Neurosci 38(3): 417-430.

  19. Zeller, A., Crestani, F., Camenisch, I., Iwasato, T., Itohara, S., Fritschy, J. M. and Rudolph, U. (2008). Cortical glutamatergic neurons mediate the motor sedative action of diazepam. Mol Pharmacol 73(2): 282-291.

  20. Li, T., Ren, G., Lusardi, T., Wilz, A., Lan, J. Q., Iwasato, T., Itohara, S., Simon, R. P. and Boison, D. (2008). Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice. J Clin Invest 118(2): 571-582.

  21. Iwasato, T., Katoh, H., Nishimaru, H., Ishikawa, Y., Inoue, H., Saito, Y. M., Ando, R., Iwama, M., Takahashi, R., Negishi, M. and Itohara, S. (2007). Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling. Cell 130(4): 742-753.

  22. Hirota, Y., Ohshima, T., Kaneko, N., Ikeda, M., Iwasato, T., Kulkarni, A. B., Mikoshiba, K., Okano, H. and Sawamoto, K. (2007). Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone. J Neurosci 27(47): 12829-12838.

  23. Earnheart, J. C., Schweizer, C., Crestani, F., Iwasato, T., Itohara, S., Mohler, H. and Luscher, B. (2007). GABAergic control of adult hippocampal neurogenesis in relation to behavior indicative of trait anxiety and depression states. J Neurosci 27(14): 3845-3854.

  24. Ohshima, T., Hirasawa, M., Tabata, H., Mutoh, T., Adachi, T., Suzuki, H., Saruta, K., Iwasato, T., Itohara, S., Hashimoto, M., Nakajima, K., Ogawa, M., Kulkarni, A. B. and Mikoshiba, K. (2007). Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex. Development 134(12): 2273-2282.

  25. Tanaka, K. F., Takebayashi, H., Yamazaki, Y., Ono, K., Naruse, M., Iwasato, T., Itohara, S., Kato, H. and Ikenaka, K. (2007). Murine model of Alexander disease: analysis of GFAP aggregate formation and its pathological significance. Glia 55(6): 617-631.

  26. Cappello, S., Attardo, A., Wu, X., Iwasato, T., Itohara, S., Wilsch-Brauninger, M., Eilken, H. M., Rieger, M. A., Schroeder, T. T., Huttner, W. B., Brakebusch, C. and Gotz, M. (2006). The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat Neurosci 9(9): 1099-1107.

  27. Gu, X., Li, C., Wei, W., Lo, V., Gong, S., Li, S. H., Iwasato, T., Itohara, S., Li, X. J., Mody, I., Heintz, N. and Yang, X. W. (2005). Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice. Neuron 46(3): 433-444.

  28. Lee, L. J., Iwasato, T., Itohara, S. and Erzurumlu, R. S. (2005). Exuberant thalamocortical axon arborization in cortex-specific NMDAR1 knockout mice. J Comp Neurol 485(4): 280-292.

Protocols by Takuji Iwasato
  1. In vitro Assay for Dendritic Spine Retraction of Hippocampal Neurons with Sparse Labeling