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Reiko Horai


Ph.D in Molecular Biology, University of Tokyo, Tokyo, Japan, 1998

Current position

Staff Scientist, Laboratory of Immunology, National Eye Institute, NIH, Bethesda, MD


  1. Horai, R., Zarate-Blades, C. R., Dillenburg-Pilla, P., Chen, J., Kielczewski, J. L., Silver, P. B., Jittayasothorn, Y., Chan, C. C., Yamane, H., Honda, K. and Caspi, R. R. (2015). Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site. Immunity 43(2): 343-353.

  2. Silver, P. B., Horai, R., Chen, J., Jittayasothorn, Y., Chan, C. C., Villasmil, R., Kesen, M. R. and Caspi, R. R. (2015). Retina-specific T regulatory cells bring about resolution and maintain remission of autoimmune uveitis. J Immunol 194(7): 3011-3019.

  3. Chong, W. P., Horai, R., Mattapallil, M. J., Silver, P. B., Chen, J., Zhou, R., Sergeev, Y., Villasmil, R., Chan, C. C. and Caspi, R. R. (2014). IL-27p28 inhibits central nervous system autoimmunity by concurrently antagonizing Th1 and Th17 responses. J Autoimmun 50: 12-22.

  4. Horai, R., Silver, P. B., Chen, J., Agarwal, R. K., Chong, W. P., Jittayasothorn, Y., Mattapallil, M. J., Nguyen, S., Natarajan, K., Villasmil, R., Wang, P., Karabekian, Z., Lytton, S. D., Chan, C. C. and Caspi, R. R. (2013). Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen. J Autoimmun 44: 21-33.

  5. Agarwal, R. K., Horai, R., Viley, A. M., Silver, P. B., Grajewski, R. S., Su, S. B., Yazdani, A. T., Zhu, W., Kronenberg, M., Murray, P. J., Rutschman, R. L., Chan, C. C. and Caspi, R. R. (2008). Abrogation of anti-retinal autoimmunity in IL-10 transgenic mice due to reduced T cell priming and inhibition of disease effector mechanisms. J Immunol 180(8): 5423-5429.

  6. Ohsugi, M., Adachi, K., Horai, R., Kakuta, S., Sudo, K., Kotaki, H., Tokai-Nishizumi, N., Sagara, H., Iwakura, Y. and Yamamoto, T. (2008). Kid-mediated chromosome compaction ensures proper nuclear envelope formation. Cell 132(5): 771-782.

  7. Horai, R., Mueller, K. L., Handon, R. A., Cannons, J. L., Anderson, S. M., Kirby, M. R. and Schwartzberg, P. L. (2007). Requirements for selection of conventional and innate T lymphocyte lineages. Immunity 27(5): 775-785.

  8. Broussard, C., Fleischacker, C., Horai, R., Chetana, M., Venegas, A. M., Sharp, L. L., Hedrick, S. M., Fowlkes, B. J. and Schwartzberg, P. L. (2006). Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity 25(1): 93-104.

  9. Matsuki, T., Isoda, K., Horai, R., Nakajima, A., Aizawa, Y., Suzuki, K., Ohsuzu, F. and Iwakura, Y. (2005). Involvement of tumor necrosis factor-alpha in the development of T cell-dependent aortitis in interleukin-1 receptor antagonist-deficient mice. Circulation 112(9): 1323-1331.

  10. Takesono, A., Horai, R., Mandai, M., Dombroski, D. and Schwartzberg, P. L. (2004). Requirement for Tec kinases in chemokine-induced migration and activation of Cdc42 and Rac. Curr Biol 14(10): 917-922.

  11. Horai, R., Nakajima, A., Habiro, K., Kotani, M., Nakae, S., Matsuki, T., Nambu, A., Saijo, S., Kotaki, H., Sudo, K., Okahara, A., Tanioka, H., Ikuse, T., Ishii, N., Schwartzberg, P. L., Abe, R. and Iwakura, Y. (2004). TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice. J Clin Invest 114(11): 1603-1611.

  12. Matsuki, T., Horai, R., Sudo, K. and Iwakura, Y. (2003). IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions. J Exp Med 198(6): 877-888.

  13. Nakae, S., Saijo, S., Horai, R., Sudo, K., Mori, S. and Iwakura, Y. (2003). IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc Natl Acad Sci U S A 100(10): 5986-5990.

  14. Horai, R., Saijo, S., Tanioka, H., Nakae, S., Sudo, K., Okahara, A., Ikuse, T., Asano, M. and Iwakura, Y. (2000). Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice. J Exp Med 191(2): 313-320.

  15. Horai, R., Asano, M., Sudo, K., Kanuka, H., Suzuki, M., Nishihara, M., Takahashi, M. and Iwakura, Y. (1998). Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion. J Exp Med 187(9): 1463-1475.

Protocols by Reiko Horai
  1. Preparation of Protein-containing Extracts from Microbiota-rich Intestinal Contents