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Phyllis B. Silver

Education

B.A. Microbiology, University of New Hampshire Durham, NH, 1975

Current position

Biologist, National Eye Institute, Laboratory of Immunology, National Institutes of Health, Bethesda, MD

Publications (since 2005)

  1. Chong, W. P., van Panhuys, N., Chen, J., Silver, P. B., Jittayasothorn, Y., Mattapallil, M. J., Germain, R. N. and Caspi, R. R. (2015). NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-gamma-IL-27 axis. J Exp Med 212(10): 1739-1752.

  2. Horai, R., Zarate-Blades, C. R., Dillenburg-Pilla, P., Chen, J., Kielczewski, J. L., Silver, P. B., Jittayasothorn, Y., Chan, C. C., Yamane, H., Honda, K. and Caspi, R. R. (2015). Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site. Immunity 43(2): 343-353.

  3. Mattapallil, M. J., Silver, P. B., Cortes, L. M., St Leger, A. J., Jittayasothorn, Y., Kielczewski, J. L., Moon, J. J., Chan, C. C. and Caspi, R. R. (2015). Characterization of a New Epitope of IRBP That Induces Moderate to Severe Uveoretinitis in Mice With H-2b Haplotype. Invest Ophthalmol Vis Sci 56(9): 5439-5449.

  4. Horai, R., Chong, W. P., Zhou, R., Chen, J., Silver, P. B., Agarwal, R. K. and Caspi, R. R. (2015). Spontaneous Ocular Autoimmunity in Mice Expressing a Transgenic T Cell Receptor Specific to Retina: A Tool to Dissect Mechanisms of Uveitis. Curr Mol Med 15(6): 511-516.

  5. Silver, P. B., Horai, R., Chen, J., Jittayasothorn, Y., Chan, C. C., Villasmil, R., Kesen, M. R. and Caspi, R. R. (2015). Retina-specific T regulatory cells bring about resolution and maintain remission of autoimmune uveitis. J Immunol 194(7): 3011-3019.

  6. Rodriguez-Pena, A. B., Gomez-Rodriguez, J., Kortum, R. L., Palmer, D. C., Yu, Z., Guittard, G. C., Wohlfert, E. A., Silver, P. B., Misplon, J. A., Sommers, C. L., Feigenbaum, L., Epstein, S. L., Caspi, R. R., Belkaid, Y., Restifo, N. P., Samelson, L. E. and Balagopalan, L. (2015). Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules. Gene Ther 22(10): 781-792.

  7. Chong, W. P., Horai, R., Mattapallil, M. J., Silver, P. B., Chen, J., Zhou, R., Sergeev, Y., Villasmil, R., Chan, C. C. and Caspi, R. R. (2014). IL-27p28 inhibits central nervous system autoimmunity by concurrently antagonizing Th1 and Th17 responses. J Autoimmun 50: 12-22.

  8. Horai, R., Silver, P. B., Chen, J., Agarwal, R. K., Chong, W. P., Jittayasothorn, Y., Mattapallil, M. J., Nguyen, S., Natarajan, K., Villasmil, R., Wang, P., Karabekian, Z., Lytton, S. D., Chan, C. C. and Caspi, R. R. (2013). Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen. J Autoimmun 44: 21-33.

  9. Agarwal, R. K., Silver, P. B. and Caspi, R. R. (2012). Rodent models of experimental autoimmune uveitis. Methods Mol Biol 900: 443-469.

  10. Zhou, R., Horai, R., Silver, P. B., Mattapallil, M. J., Zarate-Blades, C. R., Chong, W. P., Chen, J., Rigden, R. C., Villasmil, R. and Caspi, R. R. (2012). The living eye "disarms" uncommitted autoreactive T cells by converting them to Foxp3(+) regulatory cells following local antigen recognition. J Immunol 188(4): 1742-1750.

  11. Bar-Yehuda, S., Luger, D., Ochaion, A., Cohen, S., Patokaa, R., Zozulya, G., Silver, P. B., de Morales, J. M., Caspi, R. R. and Fishman, P. (2011). Inhibition of experimental auto-immune uveitis by the A3 adenosine receptor agonist CF101. Int J Mol Med 28(5): 727-731.

  12. Mattapallil, M. J., Silver, P. B., Mattapallil, J. J., Horai, R., Karabekian, Z., McDowell, J. H., Chan, C. C., James, E. A., Kwok, W. W., Sen, H. N., Nussenblatt, R. B., David, C. S. and Caspi, R. R. (2011). Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells. J Immunol 187(4): 1977-1985.

  13. Fang, J., Fang, D., Silver, P. B., Wen, F., Li, B., Ren, X., Lin, Q., Caspi, R. R. and Su, S. B. (2010). The role of TLR2, TRL3, TRL4, and TRL9 signaling in the pathogenesis of autoimmune disease in a retinal autoimmunity model. Invest Ophthalmol Vis Sci 51(6): 3092-3099.

  14. Tang, J., Zhou, R., Luger, D., Zhu, W., Silver, P. B., Grajewski, R. S., Su, S. B., Chan, C. C., Adorini, L. and Caspi, R. R. (2009). Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response. J Immunol 182(8): 4624-4632.

  15. Grajewski, R. S., Hansen, A. M., Agarwal, R. K., Kronenberg, M., Sidobre, S., Su, S. B., Silver, P. B., Tsuji, M., Franck, R. W., Lawton, A. P., Chan, C. C. and Caspi, R. R. (2008). Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-gamma production and dampening of the adaptive Th1 and Th17 responses. J Immunol 181(7): 4791-4797.

  16. Cortes, L. M., Avichezer, D., Silver, P. B., Luger, D., Mattapallil, M. J., Chan, C. C. and Caspi, R. R. (2008). Inhibitory peptide analogs derived from a major uveitogenic epitope protect from antiretinal autoimmunity by inducing type 2 and regulatory T cells. J Leukoc Biol 84(2): 577-585.

  17. Mattapallil, M. J., Sahin, A., Silver, P. B., Sun, S. H., Chan, C. C., Remmers, E. F., Hejtmancik, J. F. and Caspi, R. R. (2008). Common genetic determinants of uveitis shared with other autoimmune disorders. J Immunol 180(10): 6751-6759.

  18. Cortes, L. M., Mattapallil, M. J., Silver, P. B., Donoso, L. A., Liou, G. I., Zhu, W., Chan, C. C. and Caspi, R. R. (2008). Repertoire analysis and new pathogenic epitopes of IRBP in C57BL/6 (H-2b) and B10.RIII (H-2r) mice. Invest Ophthalmol Vis Sci 49(5): 1946-1956.

  19. Caspi, R. R., Silver, P. B., Luger, D., Tang, J., Cortes, L. M., Pennesi, G., Mattapallil, M. J. and Chan, C. C. (2008). Mouse models of experimental autoimmune uveitis. Ophthalmic Res 40(3-4): 169-174.

  20. Luger, D., Silver, P. B., Tang, J., Cua, D., Chen, Z., Iwakura, Y., Bowman, E. P., Sgambellone, N. M., Chan, C. C. and Caspi, R. R. (2008). Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med 205(4): 799-810.

  21. Agarwal, R. K., Horai, R., Viley, A. M., Silver, P. B., Grajewski, R. S., Su, S. B., Yazdani, A. T., Zhu, W., Kronenberg, M., Murray, P. J., Rutschman, R. L., Chan, C. C. and Caspi, R. R. (2008). Abrogation of anti-retinal autoimmunity in IL-10 transgenic mice due to reduced T cell priming and inhibition of disease effector mechanisms. J Immunol 180(8): 5423-5429.

  22. Silver, P. B., Agarwal, R. K., Su, S. B., Suffia, I., Grajewski, R. S., Luger, D., Chan, C. C., Mahdi, R. M., Nickerson, J. M. and Caspi, R. R. (2007). Hydrodynamic vaccination with DNA encoding an immunologically privileged retinal antigen protects from autoimmunity through induction of regulatory T cells. J Immunol 179(8): 5146-5158.

  23. Su, S. B., Grajewski, R. S., Luger, D., Agarwal, R. K., Silver, P. B., Tang, J., Tuo, J., Chan, C. C. and Caspi, R. R. (2007). Altered chemokine profile associated with exacerbated autoimmune pathology under conditions of genetic interferon-gamma deficiency. Invest Ophthalmol Vis Sci 48(10): 4616-4625.

  24. Tang, J., Zhu, W., Silver, P. B., Su, S. B., Chan, C. C. and Caspi, R. R. (2007). Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signature and is driven by unique effector mechanisms: initial encounter with autoantigen defines disease phenotype. J Immunol 178(9): 5578-5587.

  25. Grajewski, R. S., Silver, P. B., Agarwal, R. K., Su, S. B., Chan, C. C., Liou, G. I. and Caspi, R. R. (2006). Endogenous IRBP can be dispensable for generation of natural CD4+CD25+ regulatory T cells that protect from IRBP-induced retinal autoimmunity. J Exp Med 203(4): 851-856.

  26. Su, S. B., Silver, P. B., Grajewski, R. S., Agarwal, R. K., Tang, J., Chan, C. C. and Caspi, R. R. (2005). Essential role of the MyD88 pathway, but nonessential roles of TLRs 2, 4, and 9, in the adjuvant effect promoting Th1-mediated autoimmunity. J Immunol 175(10): 6303-6310.

  27. Karabekian, Z., Lytton, S. D., Silver, P. B., Sergeev, Y. V., Schneck, J. P. and Caspi, R. R. (2005). Antigen/MHC class II/Ig dimers for study of uveitogenic T cells: IRBP p161-180 presented by both IA and IE molecules. Invest Ophthalmol Vis Sci 46(10): 3769-3776.

  28. Bagenstose, L. M., Agarwal, R. K., Silver, P. B., Harlan, D. M., Hoffmann, S. C., Kampen, R. L., Chan, C. C. and Caspi, R. R. (2005). Disruption of CD40/CD40-ligand interactions in a retinal autoimmunity model results in protection without tolerance. J Immunol 175(1): 124-130.

Protocols by Phyllis B. Silver
  1. Preparation of Protein-containing Extracts from Microbiota-rich Intestinal Contents