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Fabien Marchand

Education

Ph.D in Neuropsychopharmacololgy, Faculté des Sciences Pharmaceutiques et Biologique University René Descartes, Paris V

Current position

Assistant professor in Pharmacology/Neurosciences, Inserm 1107 NeuroDol, University d’Auvergne, France

Publications (since 2005)

  1. Ferrier, J., Bayet-Robert, M., Dalmann, R., El Guerrab, A., Aissouni, Y., Graveron-Demilly, D., Chalus, M., Pinguet, J., Eschalier, A., Richard, D., Daulhac, L., Marchand, F. and Balayssac, D. (2015). Cholinergic Neurotransmission in the Posterior Insular Cortex Is Altered in Preclinical Models of Neuropathic Pain: Key Role of Muscarinic M2 Receptors in Donepezil-Induced Antinociception. J Neurosci 35(50): 16418-16430.

  2. Khairnar, A., Marchand, F., Vidal, A., Etienne, M., Miladi, I., Auzeloux, P., Cachin, F., Eschalier, A., Chezal, J. M., Ardid, D. and Miot-Noirault, E. (2015). 99mTc-NTP 15-5 Imaging for Cartilage Involvement in Experimental Rheumatoid Arthritis: Comparison with Routinely Used Molecular Imaging Methods and Sensitivity to Chronic Nonsteroidal Antiinflammatory Drug Treatment. J Nucl Med 56(5): 798-804.

  3. Gregoire, S., Wattiez, A. S., Etienne, M., Marchand, F. and Ardid, D. (2014). Monoarthritis-induced emotional and cognitive impairments in rats are sensitive to low systemic doses or intra-amygdala injections of morphine. Eur J Pharmacol 735: 1-9.

  4. Thibault, K., Calvino, B., Rivals, I., Marchand, F., Dubacq, S., McMahon, S. B. and Pezet, S. (2014). Molecular mechanisms underlying the enhanced analgesic effect of oxycodone compared to morphine in chemotherapy-induced neuropathic pain. PLoS One 9(3): e91297.

  5. Courteix, C., Ferrier, J., Marchand, F., Authier, N., Dupuis, A., Balayssac, D. and Eschalier, A. (2013). Animal Models of Toxic and Metabolic Neuropathic Pain.  In: Handwerker, H. O. and Arendt-Nielsen, L. (eds). Pain Models: Translational Relevance and Applications, IASP Press, Washington, DC©.

  6. Marchand, F., D'Mello, R., Yip, P. K., Calvo, M., Muller, E., Pezet, S., Dickenson, A. H. and McMahon, S. B. (2011). Specific involvement of atypical PKCzeta/PKMzeta in spinal persistent nociceptive processing following peripheral inflammation in rat. Mol Pain 7: 86.

  7. D'Mello, R., Marchand, F., Pezet, S., McMahon, S. B. and Dickenson, A. H. (2011). Perturbing PSD-95 interactions with NR2B-subtype receptors attenuates spinal nociceptive plasticity and neuropathic pain. Mol Ther 19(10): 1780-1792.

  8. Kaan, T. K., Yip, P. K., Patel, S., Davies, M., Marchand, F., Cockayne, D. A., Nunn, P. A., Dickenson, A. H., Ford, A. P., Zhong, Y., Malcangio, M. and McMahon, S. B. (2010). Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats. Brain 133(9): 2549-2564.

  9. Bishop, T., Marchand, F., Young, A. R., Lewin, G. R. and McMahon, S. B. (2010). Ultraviolet-B-induced mechanical hyperalgesia: A role for peripheral sensitisation. Pain 150(1): 141-152.

  10. Clark, A. K., Staniland, A. A., Marchand, F., Kaan, T. K., McMahon, S. B. and Malcangio, M. (2010). P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide. J Neurosci 30(2): 573-582.

  11. Marchand, F., Jones, N. G. and McMahon, S. B. (2009). Future treatment strategies for neuropathic pain. Handb Exp Pharmacol(194): 589-615.

  12. Authier, N., Balayssac, D., Marchand, F., Ling, B., Zangarelli, A., Descoeur, J., Coudore, F., Bourinet, E. and Eschalier, A. (2009). Animal models of chemotherapy-evoked painful peripheral neuropathies. Neurotherapeutics 6(4): 620-629.

  13. Pezet, S., Marchand, F., Thibault, K., Dauvergne, C., Grist, J., Smith, G. M., McMahon, S. B. and Calvino, B. (2009). Role of NGF in Neuronal Plasticity in the Lateral Reticular Nucleus in Chronic Inflammatory Pain. The Open Pain J.

  14. Wodarski, R., Clark, A. K., Grist, J., Marchand, F. and Malcangio, M. (2009). Gabapentin reverses microglial activation in the spinal cord of streptozotocin-induced diabetic rats. Eur J Pain 13(8): 807-811.

  15. Marchand, F., Tsantoulas, C., Singh, D., Grist, J., Clark, A. K., Bradbury, E. J. and McMahon, S. B. (2009). Effects of Etanercept and Minocycline in a rat model of spinal cord injury. Eur J Pain 13(7): 673-681.

  16. Thacker, M. A., Clark, A. K., Bishop, T., Grist, J., Yip, P. K., Moon, L. D., Thompson, S. W., Marchand, F. and McMahon, S. B. (2009). CCL2 is a key mediator of microglia activation in neuropathic pain states. Eur J Pain 13(3): 263-272.

  17. Bordet, T., Buisson, B., Michaud, M., Abitbol, J. L., Marchand, F., Grist, J., Andriambeloson, E., Malcangio, M. and Pruss, R. M. (2008). Specific antinociceptive activity of cholest-4-en-3-one, oxime (TRO19622) in experimental models of painful diabetic and chemotherapy-induced neuropathy. J Pharmacol Exp Ther 326(2): 623-632.

  18. Pezet, S., Marchand, F., D'Mello, R., Grist, J., Clark, A. K., Malcangio, M., Dickenson, A. H., Williams, R. J. and McMahon, S. B. (2008). Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions. J Neurosci 28(16): 4261-4270.

  19. Thacker, M. A., Clark, A. K., Marchand, F. and McMahon, S. B. (2007). Pathophysiology of peripheral neuropathic pain: immune cells and molecules. Anesth Analg 105(3): 838-847.

  20. Clark, A. K., Yip, P. K., Grist, J., Gentry, C., Staniland, A. A., Marchand, F., Dehvari, M., Wotherspoon, G., Winter, J., Ullah, J., Bevan, S. and Malcangio, M. (2007). Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain. Proc Natl Acad Sci U S A 104(25): 10655-10660.

  21. Barritt, A. W., Davies, M., Marchand, F., Hartley, R., Grist, J., Yip, P., McMahon, S. B. and Bradbury, E. J. (2006). Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury. J Neurosci 26(42): 10856-10867.

  22. Clark, A. K., D'Aquisto, F., Gentry, C., Marchand, F., McMahon, S. B. and Malcangio, M. (2006). Rapid co-release of interleukin 1beta and caspase 1 in spinal cord inflammation. J Neurochem 99(3): 868-880.

  23. Marchand, F., Perretti, M. and McMahon, S. B. (2005). Role of the immune system in chronic pain. Nat Rev Neurosci 6(7): 521-532.

  24. McMahon, S. B., Cafferty, W. B. and Marchand, F. (2005). Immune and glial cell factors as pain mediators and modulators. Exp Neurol 192(2): 444-462.

Protocols by Fabien Marchand
  1. Assessment of Mechanical Allodynia in Rats Using the Electronic Von Frey Test