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Ana Sevilla


Ph.D. in Cancer Biology, Centro de Investigacion del Cancer USAL-CSIC, Salamanca,Spain. 2005

Current position

Staff Scientist, New York Stem Cell Foundation Laboratory, New York, 10032, NY, USA


  1. Binda, O.*, Sevilla, A.*, LeRoy, G., Lemischka, I. R., Garcia, B. A. and Richard, S. (2013). SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal. Epigenetics 8(2): 177-183.
  2. MacArthur, B. D.*, Sevilla, A.*, Lenz, M., Muller, F. J., Schuldt, B. M., Schuppert, A. A., Ridden, S. J., Stumpf, P. S., Fidalgo, M., Ma'ayan, A., Wang, J. and Lemischka, I. R. (2012). Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity. Nat Cell Biol 14(11): 1139-1147.
  3. Lee, D. F., Su, J., Ang, Y. S., Carvajal-Vergara, X., Mulero-Navarro, S., Pereira, C. F., Gingold, J., Wang, H. L., Zhao, R., Sevilla, A., Darr, H., Williamson, A. J., Chang, B., Niu, X., Aguilo, F., Flores, E. R., Sher, Y. P., Hung, M. C., Whetton, A. D., Gelb, B. D., Moore, K. A., Snoeck, H. W., Ma'ayan, A., Schaniel, C. and Lemischka, I. R. (2012). Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell 11(2): 179-194.
  4. Sanz-Garcia, M., Monsalve, D. M., Sevilla, A. and Lazo, P. A. (2012). Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage. J Biol Chem 287(28): 23757-23768.
  5. Lee, D. F.*, Su, J.*, Sevilla*, A., Gingold, J., Schaniel, C. and Lemischka, I. R. (2012). Combining competition assays with genetic complementation strategies to dissect mouse embryonic stem cell self-renewal and pluripotency. Nat Protoc 7(4): 729-748.
  6. Ana Sevilla, Benjamin Trinite and Ihor Lemischka. Omics Era in Stem Cell Research. Data integration of a multi-regulatory layer study in mouse stem cells. A. Ma’ayan and Ben D. MacArthur (eds.), New Frontiers of Network Analysis in Systems Biology, DOI 10.1007/978-94-007-4330-4_7, Springer Science+Business Media Dordrecht 2012. Pp.119-137.
  7. Valbuena, A., Sanz-García, M., López-Sánchez, I., Vega, F. M., Sevilla, A. and Lazo, P. A. (2011). VRK1: vaccinia-related kinase 1. Encyclopedia of Signaling Molecules. Choi, S. (ed.) Springer-Verlag. In Press.
  8. Aguilo, F., Avagyan, S., Labar, A., Sevilla, A., Lee, D. F., Kumar, P., Lemischka, I. R., Zhou, B. Y. and Snoeck, H. W. (2011). Prdm16 is a physiologic regulator of hematopoietic stem cells. Blood 117(19): 5057-5066.
  9. Carvajal-Vergara, X., Sevilla, A.*, D'Souza, S. L.*, Ang, Y. S., Schaniel, C., Lee, D. F., Yang, L., Kaplan, A. D., Adler, E. D., Rozov, R., Ge, Y., Cohen, N., Edelmann, L. J., Chang, B., Waghray, A., Su, J., Pardo, S., Lichtenbelt, K. D., Tartaglia, M., Gelb, B. D. and Lemischka, I. R. (2010). Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature 465(7299): 808-812.
  10. Lazo PA, Sevilla A. ATF2 (activating transcription factor 2). Atlas Genet Cytogenet Oncol Haematol. July 2007. URL : http://AtlasGeneticsOncology.org/Genes/ATF2ID718ch2q31.html
  11. Lazo PA, Vega FM, Sevilla A, Valbuena A, Sanz-Garcia M, Lopez-Sanchez I, Blanco S. VRK1 (Vaccinia-related kinase 1). Atlas Genet Cytogenet Oncol Haematol. April 2007. URL : http://AtlasGeneticsOncology.org/Genes/VRK1ID43556ch14q32.html
  12. Valbuena, A., Lopez-Sanchez, I., Vega, F. M., Sevilla, A., Sanz-Garcia, M., Blanco, S. and Lazo, P. A. (2007). Identification of a dominant epitope in human vaccinia-related kinase 1 (VRK1) and detection of different intracellular subpopulations. Arch Biochem Biophys 465(1): 219-226.
  13. Santos, C. R., Blanco, S., Sevilla, A. and Lazo, P. A. (2006). Vaccinia virus B1R kinase interacts with JIP1 and modulates c-Jun-dependent signaling. J Virol 80(15): 7667-7675.
  14. Santos, C. R., Rodriguez-Pinilla, M., Vega, F. M., Rodriguez-Peralto, J. L., Blanco, S., Sevilla, A., Valbuena, A., Hernandez, T., van Wijnen, A. J., Li, F., de Alava, E., Sanchez-Cespedes, M. and Lazo, P. A. (2006). VRK1 signaling pathway in the context of the proliferation phenotype in head and neck squamous cell carcinoma. Mol Cancer Res 4(3): 177-185.
  15. Lazo, P.A., Blanco, S., Sevilla, A. (2004). Biología molecular y celular de la diseminación tumoral y metastasis. En: Virus y Cáncer In: Moyano, A., Gónzalez-Lahoz, J., Fernández-Munoz, R. (eds). Vol.2: Chapter V.p100-116.
  16. Vega, F. M., Sevilla, A. and Lazo, P. A. (2004). p53 Stabilization and accumulation induced by human vaccinia-related kinase 1. Mol Cell Biol 24(23): 10366-10380.
  17. Pala, T. R. and Sevilla, A. (2004). Microbial contamination of carcasses, meat, and equipment from an Iberian pork cutting plant. J Food Prot 67(8): 1624-1629.
  18. Sevilla, A., Santos, C. R., Barcia, R., Vega, F. M. and Lazo, P. A. (2004). c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK). Oncogene 23(55): 8950-8958.
  19. Sevilla, A., Santos, C. R., Vega, F. M. and Lazo, P. A. (2004). Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK. J Biol Chem 279(26): 27458-27465.
Protocols by Ana Sevilla
  1. Single-cell Gene Expression Profiling of Mouse Stem Cells With Fluidigm BiomarkTM Dynamic Array