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M. Celeste Simon


Ph.D. in The Rockefeller University Molecular Biology, 1985

Current position

Scientific Director, Abramson Family Cancer Research Institute (AFCRI)

Publications (since 2012)

  1. Yoon, C., Chang, K. K., Lee, J. H., Tap, W. D., Hart, C. P., Simon, M. C. and Yoon, S. S. (2016). Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1alpha inhibition, and hypoxia-activated chemotherapy. Oncotarget.

  2. Lee, K. E., Spata, M., Bayne, L. J., Buza, E. L., Durham, A. C., Allman, D., Vonderheide, R. H. and Simon, M. C. (2016). Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia. Cancer Discov 6(3): 256-269.

  3. Nakazawa, M. S., Eisinger-Mathason, T. S., Sadri, N., Ochocki, J. D., Gade, T. P., Amin, R. K. and Simon, M. C. (2016). Epigenetic re-expression of HIF-2alpha suppresses soft tissue sarcoma growth. Nat Commun 7: 10539.

  4. Altman, B. J., Hsieh, A. L., Sengupta, A., Krishnanaiah, S. Y., Stine, Z. E., Walton, Z. E., Gouw, A. M., Venkataraman, A., Li, B., Goraksha-Hicks, P., Diskin, S. J., Bellovin, D. I., Simon, M. C., Rathmell, J. C., Lazar, M. A., Maris, J. M., Felsher, D. W., Hogenesch, J. B., Weljie, A. M. and Dang, C. V. (2015). MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells. Cell Metab 22(6): 1009-1019.

  5. Lee, K. E. and Simon, M. C. (2015). SnapShot: Hypoxia-Inducible Factors. Cell 163(5): 1288-1288 e1281.

  6. Qiu, B. and Simon, M. C. (2015). Oncogenes strike a balance between cellular growth and homeostasis. Semin Cell Dev Biol 43: 3-10.

  7. Eisinger-Mathason, T. S., Mucaj, V., Biju, K. M., Nakazawa, M. S., Gohil, M., Cash, T. P., Yoon, S. S., Skuli, N., Park, K. M., Gerecht, S. and Simon, M. C. (2015). Deregulation of the Hippo pathway in soft-tissue sarcoma promotes FOXM1 expression and tumorigenesis. Proc Natl Acad Sci U S A 112(26): E3402-3411.

  8. Walsh, A. M., Kapoor, G. S., Buonato, J. M., Mathew, L. K., Bi, Y., Davuluri, R. V., Martinez-Lage, M., Simon, M. C., O'Rourke, D. M. and Lazzara, M. J. (2015). Sprouty2 Drives Drug Resistance and Proliferation in Glioblastoma. Mol Cancer Res 13(8): 1227-1237.

  9. Gade, T. P., Hunt, S. J., Harrison, N., Nadolski, G. J., Weber, C., Pickup, S., Furth, E. E., Schnall, M. D., Soulen, M. C. and Celeste Simon, M. (2015). Segmental Transarterial Embolization in a Translational Rat Model of Hepatocellular Carcinoma. J Vasc Interv Radiol 26(8): 1229-1237.

  10. Majmundar, A. J., Lee, D. S., Skuli, N., Mesquita, R. C., Kim, M. N., Yodh, A. G., Nguyen-McCarty, M., Li, B. and Simon, M. C. (2015). HIF modulation of Wnt signaling regulates skeletal myogenesis in vivo. Development 142(14): 2405-2412.

  11. Yoon, C., Lee, H. J., Park, D. J., Lee, Y. J., Tap, W. D., Eisinger-Mathason, T. S., Hart, C. P., Choy, E., Simon, M. C. and Yoon, S. S. (2015). Hypoxia-activated chemotherapeutic TH-302 enhances the effects of VEGF-A inhibition and radiation on sarcomas. Br J Cancer 113(1): 46-56.

  12. Krock, B. L., Eisinger-Mathason, T. S., Giannoukos, D. N., Shay, J. E., Gohil, M., Lee, D. S., Nakazawa, M. S., Sesen, J., Skuli, N. and Simon, M. C. (2015). The aryl hydrocarbon receptor nuclear translocator is an essential regulator of murine hematopoietic stem cell viability. Blood 125(21): 3263-3272.

  13. Qiu, B., Ackerman, D., Sanchez, D. J., Li, B., Ochocki, J. D., Grazioli, A., Bobrovnikova-Marjon, E., Diehl, J. A., Keith, B. and Simon, M. C. (2015). HIF2alpha-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma. Cancer Discov 5(6): 652-667.

  14. Mathew, L. K., Huangyang, P., Mucaj, V., Lee, S. S., Skuli, N., Eisinger-Mathason, T. S., Biju, K., Li, B., Venneti, S., Lal, P., Lathia, J. D., Rich, J. N., Keith, B. and Simon, M. C. (2015). Feedback circuitry between miR-218 repression and RTK activation in glioblastoma. Sci Signal 8(375): ra42.

  15. Mucaj, V., Lee, S. S., Skuli, N., Giannoukos, D. N., Qiu, B., Eisinger-Mathason, T. S., Nakazawa, M. S., Shay, J. E., Gopal, P. P., Venneti, S., Lal, P., Minn, A. J., Simon, M. C. and Mathew, L. K. (2015). MicroRNA-124 expression counteracts pro-survival stress responses in glioblastoma. Oncogene 34(17): 2204-2214.

  16. Lee, H. J., Yoon, C., Park do, J., Kim, Y. J., Schmidt, B., Lee, Y. J., Tap, W. D., Eisinger-Mathason, T. S., Choy, E., Kirsch, D. G., Simon, M. C. and Yoon, S. S. (2015). Inhibition of vascular endothelial growth factor A and hypoxia-inducible factor 1alpha maximizes the effects of radiation in sarcoma mouse models through destruction of tumor vasculature. Int J Radiat Oncol Biol Phys 91(3): 621-630.

  17. Ye, J., Fan, J., Venneti, S., Wan, Y. W., Pawel, B. R., Zhang, J., Finley, L. W., Lu, C., Lindsten, T., Cross, J. R., Qing, G., Liu, Z., Simon, M. C., Rabinowitz, J. D. and Thompson, C. B. (2014). Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov 4(12): 1406-1417.

  18. Wong, W. J., Richardson, T., Seykora, J. T., Cotsarelis, G. and Simon, M. C. (2015). Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function. J Invest Dermatol 135(2): 454-461.

  19. Villa, J. C., Chiu, D., Brandes, A. H., Escorcia, F. E., Villa, C. H., Maguire, W. F., Hu, C. J., de Stanchina, E., Simon, M. C., Sisodia, S. S., Scheinberg, D. A. and Li, Y. M. (2014). Nontranscriptional role of Hif-1alpha in activation of gamma-secretase and notch signaling in breast cancer. Cell Rep 8(4): 1077-1092.

  20. Furcht, C. M., Buonato, J. M., Skuli, N., Mathew, L. K., Munoz Rojas, A. R., Simon, M. C. and Lazzara, M. J. (2014). Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells. J Cell Sci 127(Pt 16): 3555-3567.

  21. Li, B., Qiu, B., Lee, D. S., Walton, Z. E., Ochocki, J. D., Mathew, L. K., Mancuso, A., Gade, T. P., Keith, B., Nissim, I. and Simon, M. C. (2014). Fructose-1,6-bisphosphatase opposes renal carcinoma progression. Nature 513(7517): 251-255.

  22. Ackerman, D. and Simon, M. C. (2014). Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment. Trends Cell Biol 24(8): 472-478.

  23. Shay, J. E., Imtiyaz, H. Z., Sivanand, S., Durham, A. C., Skuli, N., Hsu, S., Mucaj, V., Eisinger-Mathason, T. S., Krock, B. L., Giannoukos, D. N. and Simon, M. C. (2014). Inhibition of hypoxia-inducible factors limits tumor progression in a mouse model of colorectal cancer. Carcinogenesis 35(5): 1067-1077.

  24. Thompson, A. A., Elks, P. M., Marriott, H. M., Eamsamarng, S., Higgins, K. R., Lewis, A., Williams, L., Parmar, S., Shaw, G., McGrath, E. E., Formenti, F., Van Eeden, F. J., Kinnula, V. L., Pugh, C. W., Sabroe, I., Dockrell, D. H., Chilvers, E. R., Robbins, P. A., Percy, M. J., Simon, M. C., Johnson, R. S., Renshaw, S. A., Whyte, M. K. and Walmsley, S. R. (2014). Hypoxia-inducible factor 2alpha regulates key neutrophil functions in humans, mice, and zebrafish. Blood 123(3): 366-376.

  25. Wagage, S., John, B., Krock, B. L., Hall, A. O., Randall, L. M., Karp, C. L., Simon, M. C. and Hunter, C. A. (2014). The aryl hydrocarbon receptor promotes IL-10 production by NK cells. J Immunol 192(4): 1661-1670.

  26. Mathew, L. K., Lee, S. S., Skuli, N., Rao, S., Keith, B., Nathanson, K. L., Lal, P. and Simon, M. C. (2014). Restricted expression of miR-30c-2-3p and miR-30a-3p in clear cell renal cell carcinomas enhances HIF2alpha activity. Cancer Discov 4(1): 53-60.

  27. Mathew, L. K., Skuli, N., Mucaj, V., Lee, S. S., Zinn, P. O., Sathyan, P., Imtiyaz, H. Z., Zhang, Z., Davuluri, R. V., Rao, S., Venneti, S., Lal, P., Lathia, J. D., Rich, J. N., Keith, B., Minn, A. J. and Simon, M. C. (2014). miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma. Proc Natl Acad Sci U S A 111(1): 291-296.

  28. Arsenault, P. R., Pei, F., Lee, R., Kerestes, H., Percy, M. J., Keith, B., Simon, M. C., Lappin, T. R., Khurana, T. S. and Lee, F. S. (2013). A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism. J Biol Chem 288(47): 33571-33584.

  29. Li, B. and Simon, M. C. (2013). Molecular Pathways: Targeting MYC-induced metabolic reprogramming and oncogenic stress in cancer. Clin Cancer Res 19(21): 5835-5841.

  30. Ochocki, J. D. and Simon, M. C. (2013). Nutrient-sensing pathways and metabolic regulation in stem cells. J Cell Biol 203(1): 23-33.

  31. Eisinger-Mathason, T. S., Zhang, M., Qiu, Q., Skuli, N., Nakazawa, M. S., Karakasheva, T., Mucaj, V., Shay, J. E., Stangenberg, L., Sadri, N., Pure, E., Yoon, S. S., Kirsch, D. G. and Simon, M. C. (2013). Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis. Cancer Discov 3(10): 1190-1205.

  32. Wei, K., Piecewicz, S. M., McGinnis, L. M., Taniguchi, C. M., Wiegand, S. J., Anderson, K., Chan, C. W., Mulligan, K. X., Kuo, D., Yuan, J., Vallon, M., Morton, L. C., Lefai, E., Simon, M. C., Maher, J. J., Mithieux, G., Rajas, F., Annes, J. P., McGuinness, O. P., Thurston, G., Giaccia, A. J. and Kuo, C. J. (2013). A liver Hif-2alpha-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nat Med 19(10): 1331-1337.

  33. Licciulli, S., Avila, J. L., Hanlon, L., Troutman, S., Cesaroni, M., Kota, S., Keith, B., Simon, M. C., Pure, E., Radtke, F., Capobianco, A. J. and Kissil, J. L. (2013). Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53. Cancer Res 73(19): 5974-5984.

  34. Wong, W. J., Qiu, B., Nakazawa, M. S., Qing, G. and Simon, M. C. (2013). MYC degradation under low O2 tension promotes survival by evading hypoxia-induced cell death. Mol Cell Biol 33(17): 3494-3504.

  35. Young, R. M., Ackerman, D., Quinn, Z. L., Mancuso, A., Gruber, M., Liu, L., Giannoukos, D. N., Bobrovnikova-Marjon, E., Diehl, J. A., Keith, B. and Simon, M. C. (2013). Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress. Genes Dev 27(10): 1115-1131.

  36. Hanna, S. C., Krishnan, B., Bailey, S. T., Moschos, S. J., Kuan, P. F., Shimamura, T., Osborne, L. D., Siegel, M. B., Duncan, L. M., O'Brien, E. T., 3rd, Superfine, R., Miller, C. R., Simon, M. C., Wong, K. K. and Kim, W. Y. (2013). HIF1alpha and HIF2alpha independently activate SRC to promote melanoma metastases. J Clin Invest 123(5): 2078-2093.

  37. McClain, D. A., Abuelgasim, K. A., Nouraie, M., Salomon-Andonie, J., Niu, X., Miasnikova, G., Polyakova, L. A., Sergueeva, A., Okhotin, D. J., Cherqaoui, R., Okhotin, D., Cox, J. E., Swierczek, S., Song, J., Simon, M. C., Huang, J., Simcox, J. A., Yoon, D., Prchal, J. T. and Gordeuk, V. R. (2013). Decreased serum glucose and glycosylated hemoglobin levels in patients with Chuvash polycythemia: a role for HIF in glucose metabolism. J Mol Med (Berl) 91(1): 59-67.

  38. Kim, Y. J., Lee, H. J., Kim, T. M., Eisinger-Mathason, T. S., Zhang, A. Y., Schmidt, B., Karl, D. L., Nakazawa, M. S., Park, P. J., Simon, M. C. and Yoon, S. S. (2013). Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia-inducible factor 1alpha. Int J Cancer 132(1): 29-41.

  39. Gao, Y., Sartori, D. J., Li, C., Yu, Q. C., Kushner, J. A., Simon, M. C. and Diehl, J. A. (2012). PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis. Mol Cell Biol 32(24): 5129-5139.

  40. Qing, G., Li, B., Vu, A., Skuli, N., Walton, Z. E., Liu, X., Mayes, P. A., Wise, D. R., Thompson, C. B., Maris, J. M., Hogarty, M. D. and Simon, M. C. (2012). ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation. Cancer Cell 22(5): 631-644.

  41. Glick, D., Zhang, W., Beaton, M., Marsboom, G., Gruber, M., Simon, M. C., Hart, J., Dorn, G. W., 2nd, Brady, M. J. and Macleod, K. F. (2012). BNip3 regulates mitochondrial function and lipid metabolism in the liver. Mol Cell Biol 32(13): 2570-2584.

  42. Young, R. M. and Simon, M. C. (2012). Untuning the tumor metabolic machine: HIF-alpha: pro- and antitumorigenic? Nat Med 18(7): 1024-1025.

  43. Qi, Y., Tian, X., Liu, J., Han, Y., Graham, A. M., Simon, M. C., Penninger, J. M., Carmeliet, P. and Li, S. (2012). Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis. J Cell Biol 198(1): 103-114.

  44. Mucaj, V., Shay, J. E. and Simon, M. C. (2012). Effects of hypoxia and HIFs on cancer metabolism. Int J Hematol 95(5): 464-470.

  45. Shay, J. E. and Celeste Simon, M. (2012). Hypoxia-inducible factors: crosstalk between inflammation and metabolism. Semin Cell Dev Biol 23(4): 389-394.

  46. Skuli, N., Majmundar, A. J., Krock, B. L., Mesquita, R. C., Mathew, L. K., Quinn, Z. L., Runge, A., Liu, L., Kim, M. N., Liang, J., Schenkel, S., Yodh, A. G., Keith, B. and Simon, M. C. (2012). Endothelial HIF-2alpha regulates murine pathological angiogenesis and revascularization processes. J Clin Invest 122(4): 1427-1443.

  47. Lee, K. E. and Simon, M. C. (2012). From stem cells to cancer stem cells: HIF takes the stage. Curr Opin Cell Biol 24(2): 232-235.

  48. Dondeti, V. R., Wubbenhorst, B., Lal, P., Gordan, J. D., D'Andrea, K., Attiyeh, E. F., Simon, M. C. and Nathanson, K. L. (2012). Integrative genomic analyses of sporadic clear cell renal cell carcinoma define disease subtypes and potential new therapeutic targets. Cancer Res 72(1): 112-121.

  49. Majmundar, A. J., Skuli, N., Mesquita, R. C., Kim, M. N., Yodh, A. G., Nguyen-McCarty, M. and Simon, M. C. (2012). O(2) regulates skeletal muscle progenitor differentiation through phosphatidylinositol 3-kinase/AKT signaling. Mol Cell Biol 32(1): 36-49.

  50. Keith, B., Johnson, R. S. and Simon, M. C. (2012). HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer 12(1): 9-22.

Protocols by M. Celeste Simon
  1. BODIPY 493/503 Staining of Neutral Lipid Droplets for Microscopy and Quantification by Flow Cytometry