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Maik Stiehler

Education

Ph.D., interdisciplinary “Nanoscience and Biocompatibility Project” at the Department of Orthopaedics, Aarhus University Hospital, Denmark and at the Institute of Molecular Biology, Aarhus University, Denmark

Current position

Head of Septic Surgery Unit, Department of Orthopaedics, University Hospital Carl Gustav Carus at Technische Universität Dresden, Germany
Head of Experimental Research Group (Netzwerklabor of Sektion Grundlagenforschung DGOOC), Department of Orthopaedics and
Head of BMBF/DAAD German-Chinese junior researcher group “Modern applications of biotechnology", Department of Orthopaedics, University Hospital Carl Gustav Carus at Technische Universität Dresden, Germany
Head of Dresden Bone Bank (certified according to §21a AMG), Department of Orthopaedics, University Hospital Carl Gustav Carus at Technische Universität Dresden, Germany

Publications

  1. Stiehler, M., Goronzy, J. and Gunther, K. P. (2015). [Total hip arthroplasty in overweight osteoarthritis patients]. Orthopade 44(7): 523-530.

  2. Stiehler, M., Goronzy, J., Kirschner, S., Hartmann, A., Schafer, T. and Gunther, K. P. (2015). Effect of surgical experience on imageless computer-assisted femoral component positioning in hip resurfacing--a preclinical study. Eur J Med Res 20: 18.

  3. Tang, Y., Jacobi, A., Vater, C., Zou, L., Zou, X. and Stiehler, M. (2015). Icariin promotes angiogenic differentiation and prevents oxidative stress-induced autophagy in endothelial progenitor cells. Stem Cells 33(6): 1863-1877.

  4. Rauh, J., Jacobi, A. and Stiehler, M. (2015). Identification of stable reference genes for gene expression analysis of three-dimensional cultivated human bone marrow-derived mesenchymal stromal cells for bone tissue engineering. Tissue Eng Part C Methods 21(2): 192-206.

  5. Gunther, K. P., Stiehler, M., Goronzy, J., Schneiders, W. and Hartmann, A. (2015). [Arthroplasty for osteoarthritis secondary to hip dysplasia: Problem-oriented treatment strategies]. Orthopade 44(7): 497-498, 500-499.

  6. Wobus, M., List, C., Dittrich, T., Dhawan, A., Duryagina, R., Arabanian, L. S., Kast, K., Wimberger, P., Stiehler, M., Hofbauer, L. C., Jakob, F., Ehninger, G., Anastassiadis, K. and Bornhauser, M. (2015). Breast carcinoma cells modulate the chemoattractive activity of human bone marrow-derived mesenchymal stromal cells by interfering with CXCL12. Int J Cancer 136(1): 44-54.

  7. Tang, Y., Jacobi, A., Vater, C., Zou, X. and Stiehler, M. (2014). Salvianolic acid B protects human endothelial progenitor cells against oxidative stress-mediated dysfunction by modulating Akt/mTOR/4EBP1, p38 MAPK/ATF2, and ERK1/2 signaling pathways. Biochem Pharmacol 90(1): 34-49.

  8. Rauh, J., Despang, F., Baas, J., Liebers, C., Pruss, A., Gelinsky, M., Gunther, K. P. and Stiehler, M. (2014). Comparative biomechanical and microstructural analysis of native versus peracetic acid-ethanol treated cancellous bone graft. Biomed Res Int 2014: 784702.

  9. Tang, Y., Vater, C., Jacobi, A., Liebers, C., Zou, X. and Stiehler, M. (2014). Salidroside exerts angiogenic and cytoprotective effects on human bone marrow-derived endothelial progenitor cells via Akt/mTOR/p70S6K and MAPK signalling pathways. Br J Pharmacol 171(9): 2440-2456.

  10. Schmidt, C. P., Zwingenberger, S., Walther, A., Reuter, U., Kasten, P., Seifert, J., Gunther, K. P. and Stiehler, M. (2014). Prevalence of low back pain in adolescent athletes - an epidemiological investigation. Int J Sports Med 35(8): 684-689.

  11. Zwingenberger, S., Yao, Z., Jacobi, A., Vater, C., Valladares, R. D., Li, C., Nich, C., Rao, A. J., Christman, J. E., Antonios, J. K., Gibon, E., Schambach, A., Maetzig, T., Goodman, S. B. and Stiehler, M. (2014). Enhancement of BMP-2 induced bone regeneration by SDF-1alpha mediated stem cell recruitment. Tissue Eng Part A 20(3-4): 810-818.

  12. Bernstein, P., Beuthien-Baumann, B., Kotzerke, J., Hofheinz, F., Zessin, J., Stiehler, M. and Gunther, K. P. (2014). Periacetabular bone metabolism following hip revision surgery. PET-based evaluation of allograft osteointegration. Nuklearmedizin 53(4): 147-154.

  13. Zwingenberger, S., Valladares, R. D., Walther, A., Beck, H., Stiehler, M., Kirschner, S., Engelhardt, M. and Kasten, P. (2014). An epidemiological investigation of training and injury patterns in triathletes. J Sports Sci 32(6): 583-590.

  14. Rolfing, J. H., Baatrup, A., Stiehler, M., Jensen, J., Lysdahl, H. and Bunger, C. (2014). The osteogenic effect of erythropoietin on human mesenchymal stromal cells is dose-dependent and involves non-hematopoietic receptors and multiple intracellular signaling pathways. Stem Cell Rev 10(1): 69-78.

  15. Stiehler, M., Zobel, F., Hannemann, F., Schmitt, J., Lutzner, J., Kirschner, S., Gunther, K. P. and Hartmann, A. (2014). [Complications of metal-on-metal tribological pairing]. Orthopade 43(1): 79-91.

  16. Schildberg, T., Rauh, J., Bretschneider, H. and Stiehler, M. (2013). Identification of suitable reference genes in bone marrow stromal cells from osteoarthritic donors. Stem Cell Res 11(3): 1288-1298.

  17. Stiehler, C., Bünger, C., Overall, R. W., Royer, L., Schroeder, M., Foss, M., Besenbacher, F., Kruhoffer, M., Kassem, M., Günther, K. P. and Stiehler, M. (2013). Whole-genome expression analysis of human mesenchymal stromal cells exposed to ultrasmooth tantalum versus titanium oxide surfaces. Cell Mol Bioeng 6: 199-209.

  18. Bernstein, P., Kirschner, S. and Stiehler, M. (2013). [Academic clinical medicine in orthopedic and trauma surgery: which route will the next generation choose?]. Unfallchirurg 116(6): 563-569.

  19. Jacobi, A., Rauh, J., Bernstein, P., Liebers, C., Zou, X. and Stiehler, M. (2013). Comparative analysis of reference gene stability in human mesenchymal stromal cells during osteogenic differentiation. Biotechnol Prog 29(4): 1034-1042.

  20. Stiehler, M., Goronzy, J., Hartmann, A., Krummenauer, F. and Gunther, K. P. (2013). The First SICOT Oral Presentation Award 2011: imageless computer-assisted femoral component positioning in hip resurfacing: a prospective randomised trial. Int Orthop 37(4): 569-581.

  21. Zwingenberger, S., Yao, Z., Jacobi, A., Vater, C., Valladares, R. D., Li, C., Nich, C., Rao, A. J., Christman, J. E., Antonios, J. K., Gibon, E., Schambach, A., Matzig, T., Gunther, K. P., Goodman, S. B. and Stiehler, M. (2013). Stem cell attraction via SDF-1alpha expressing fat tissue grafts. J Biomed Mater Res A 101(7): 2067-2074.

  22. Zwingenberger, S., Niederlohmann, E., Vater, C., Rammelt, S., Matthys, R., Bernhardt, R., Valladares, R. D., Goodman, S. B. and Stiehler, M. (2013). Establishment of a femoral critical-size bone defect model in immunodeficient mice. J Surg Res 181(1): e7-e14.

  23. Ferrer, R. A., Wobus, M., List, C., Wehner, R., Schonefeldt, C., Brocard, B., Mohr, B., Rauner, M., Schmitz, M., Stiehler, M., Ehninger, G., Hofbauer, L. C., Bornhauser, M. and Platzbecker, U. (2013). Mesenchymal stromal cells from patients with myelodyplastic syndrome display distinct functional alterations that are modulated by lenalidomide. Haematologica 98(11): 1677-1685.

  24. Gunther, K. P., Lutzner, J., Hannemann, F., Schmitt, J., Kirschner, S., Goronzy, J., Stiehler, M., Lohmann, C. and Hartmann, A. (2013). [Update on metal-on-metal hip joints]. Orthopade 42(5): 373-387; quiz 388-379.

  25. Rolfing, J. H., Bendtsen, M., Jensen, J., Stiehler, M., Foldager, C. B., Hellfritzsch, M. B. and Bunger, C. (2012). Erythropoietin augments bone formation in a rabbit posterolateral spinal fusion model. J Orthop Res 30(7): 1083-1088.

  26. Zwingenberger, S., Nich, C., Valladares, R. D., Yao, Z., Stiehler, M. and Goodman, S. B. (2012). Recommendations and considerations for the use of biologics in orthopedic surgery. BioDrugs 26(4): 245-256.

  27. Rauh, J., Milan, F., Gunther, K. P. and Stiehler, M. (2011). Bioreactor systems for bone tissue engineering. Tissue Eng Part B Rev 17(4): 263-280.

  28. Vater, C., Kasten, P. and Stiehler, M. (2011). Culture media for the differentiation of mesenchymal stromal cells. Acta Biomater 7(2): 463-477.

  29. Bernstein, P., Sticht, C., Jacobi, A., Liebers, C., Manthey, S. and Stiehler, M. (2010). Expression pattern differences between osteoarthritic chondrocytes and mesenchymal stem cells during chondrogenic differentiation. Osteoarthritis Cartilage 18(12): 1596-1607.

  30. Goronzy, J., Stiehler, M., Kirschner, S. and Gunther, K. P. (2010). [Durom hip resurfacing. Short- to midterm clinical and radiological outcome]. Orthopade 39(9): 842-852.

  31. Stiehler, M., Seib, F. P., Rauh, J., Goedecke, A., Werner, C., Bornhauser, M., Gunther, K. P. and Bernstein, P. (2010). Cancellous bone allograft seeded with human mesenchymal stromal cells: a potential good manufacturing practice-grade tool for the regeneration of bone defects. Cytotherapy 12(5): 658-668.

  32. Bernstein, P., Stiehler, M. and Haasper, C. (2010). [Survey of the simultaneous management of clinical and research burdens in German University orthopaedic and trauma departments]. Z Orthop Unfall 148(2): 155-162.

  33. Stiehler, M., Bunger, C., Baatrup, A., Lind, M., Kassem, M. and Mygind, T. (2009). Effect of dynamic 3-D culture on proliferation, distribution, and osteogenic differentiation of human mesenchymal stem cells. J Biomed Mater Res A 89(1): 96-107.

  34. Thieme, S., Ryser, M., Gentsch, M., Navratiel, K., Brenner, S., Stiehler, M., Rolfing, J., Gelinsky, M. and Rosen-Wolff, A. (2009). Stromal cell-derived factor-1alpha-directed chemoattraction of transiently CXCR4-overexpressing bone marrow stromal cells into functionalized three-dimensional biomimetic scaffolds. Tissue Eng Part C Methods 15(4): 687-696.

  35. Stiehler, M., Lind, M., Mygind, T., Baatrup, A., Dolatshahi-Pirouz, A., Li, H., Foss, M., Besenbacher, F., Kassem, M. and Bunger, C. (2008). Morphology, proliferation, and osteogenic differentiation of mesenchymal stem cells cultured on titanium, tantalum, and chromium surfaces. J Biomed Mater Res A 86(2): 448-458.

  36. Mygind, T., Stiehler, M., Baatrup, A., Li, H., Zou, X., Flyvbjerg, A., Kassem, M. and Bunger, C. (2007). Mesenchymal stem cell ingrowth and differentiation on coralline hydroxyapatite scaffolds. Biomaterials 28(6): 1036-1047.

  37. Stiehler, M., Duch, M., Mygind, T., Li, H., Ulrich-Vinther, M., Modin, C., Baatrup, A., Lind, M., Pedersen, F. S. and Bunger, C. E. (2006). Optimizing viral and non-viral gene transfer methods for genetic modification of porcine mesenchymal stem cells. Adv Exp Med Biol 585: 31-48.

  38. Hertel, R., Hempfing, A., Stiehler, M. and Leunig, M. (2004). Predictors of humeral head ischemia after intracapsular fracture of the proximal humerus. J Shoulder Elbow Surg 13(4): 427-433.

  39. Behr, T. M., Behe, M., Angerstein, C., Gratz, S., Mach, R., Hagemann, L., Jenner, N., Stiehler, M., Frank-Raue, K., Raue, F. and Becker, W. (1999). Cholecystokinin-B/gastrin receptor binding peptides: preclinical development and evaluation of their diagnostic and therapeutic potential. Clin Cancer Res 5(10 Suppl): 3124s-3138s.

  40. Bernstein, P., Bornhauser, M., Gunther, K. P. and Stiehler, M. (2009). [Bone tissue engineering in clinical application : assessment of the current situation]. Orthopade 38(11): 1029-1037.

  41. Gunther, K. P., Witzleb, W. C., Stiehler, M. and Kirschner, S. (2008). [Revision surgery of hip resurfacing]. Orthopade 37(7): 685-694.

Protocols by Maik Stiehler
  1. Bone Marrow-derived Endothelial Progenitor Cell Intercellular Adhesion Assay