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Joseph Loscalzo

Education

D.Sc. (Hon.) in Elmezzi Graduate School of Molecular Medicine Hofstra University, 2008
M.A. (Hon.) in Harvard University, 2005
Ph.D. in Biochemistry, University of Pennsylvania, 1977

Current position

Hersey Professor of the Theory and Practice of Medicine, Harvard Medical School
Chairman, Department of Medicine, Brigham and Women’s Hospital
Physician-in-Chief

Publications (since 2015)

  1. Loscalzo, J. (2016). The Future of Medical Journal Publishing: The Journal Editor's Perspective: Looking Back, Looking Forward. Circulation 133(16): 1621-1624.

  2. Loscalzo, J. (2016). The blood vessel and its disorders: a brief, early history of vascular physiology and medicine in Boston.  In: Forest, Jr. J. N. (Ed). A Record of Achievement in Clinical and Biomedical Science.  New York:New York Academy of Sciences, pp.75-82.

  3. Shah, S. H., Arnett, D., Houser, S. R., Ginsburg, G. S., MacRae, C., Mital, S., Loscalzo, J. and Hall, J. L. (2016). Opportunities for the Cardiovascular Community in the Precision Medicine Initiative. Circulation 133(2): 226-231.

  4. Yang, Y., Zhao, Y., Wang, A., Zou, Y., Su, N. and Loscalzo, J. (2016). In vivo monitoring of cellular energy metabolism using a highly responsive sensor for NAD+/NADH redox state. Nature Protocols 11, 1345–1359

  5. Aghamohammadzadeh, R., Zhang, Y. Y., Stephens, T. E., Arons, E., Zaman, P., Polach, K. J., Matar, M., Yung, L. M., Yu, P. B., Bowman, F. P., Opotowsky, A. R., Waxman, A. B., Loscalzo, J., Leopold, J. A. and Maron, B. A. (2016). Up-regulation of the mammalian target of rapamycin complex 1 subunit Raptor by aldosterone induces abnormal pulmonary artery smooth muscle cell survival patterns to promote pulmonary arterial hypertension. FASEB J 30(7): 2511-2527.

  6. Wang, R. S. and Loscalzo, J. (2016). Illuminating drug action by network integration of disease genes: a case study of myocardial infarction. Mol Biosyst 12(5): 1653-1666.

  7. Garmaroudi, F. S., Handy, D. E., Liu, Y. Y. and Loscalzo, J. (2016). Systems Pharmacology and Rational Polypharmacy: Nitric Oxide-Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case. PLoS Comput Biol 12(3): e1004822.

  8. Alexander, K. M., Veillet-Chowdhury, M. R., MacIntyre, C. J., Loscalzo, J. and Bhatt, D. L. (2016). A Shocking Development in a Young Male Athlete With Chest Pain. Circulation 133(8): 756-763.

  9. Mogabgab, O. N., Osman, N. Y., Wei, K., Batal, I. and Loscalzo, J. (2016). CLINICAL PROBLEM-SOLVING. A Complementary Affair. N Engl J Med 374(1): 74-81.

  10. Maron, B. A., Stephens, T. E., Farrell, L. A., Oldham, W. M., Loscalzo, J., Leopold, J. A. and Lewis, G. D. (2016). Elevated pulmonary arterial and systemic plasma aldosterone levels associate with impaired cardiac reserve capacity during exercise in left ventricular systolic heart failure patients: A pilot study. J Heart Lung Transplant 35(3): 342-351.

  11. Michel, T. and Loscalzo, J. (2015). Nitroglycerin and Nitric Oxide--A Rondo of Themes in Cardiovascular Therapeutics. N Engl J Med 373(18): 1789.

  12. Barroso, M., Kao, D., Blom, H. J., Tavares de Almeida, I., Castro, R., Loscalzo, J. and Handy, D. E. (2016). S-adenosylhomocysteine induces inflammation through NFkB: A possible role for EZH2 in endothelial cell activation. Biochim Biophys Acta 1862(1): 82-92.

  13. Oldham, W.M. and Loscalzo, J. (2016). Pharmacology of vascular tone. In: Golan, D.E., Armstrong, E.J. and Armstrong, A.W. (Eds). Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 4th Edition.  Philadelphia, PA:Wolters Kluwer/Lippincott, Williams, and Wilkins, pp.385-402. 

  14. Rabin, A. S., Hamnvik, O. P., Robinson, E. S., Miller, A. L. and Loscalzo, J. (2015). CLINICAL PROBLEM-SOLVING. Springing a Leak. N Engl J Med 373(14): 1362-1367.

  15. Abdalla, M., Sax, P. E., Mostaghimi, A., Miller, A. L. and Loscalzo, J. (2015). CLINICAL PROBLEM-SOLVING. On the Nose. N Engl J Med 373(10): 955-961.

  16. Greka, A. and Loscalzo, J. (2015). New Approaches to the Treatment of Hyperkalemia? In: Longo, D. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., Jameson, J. L. and Loscalzo, J. (Eds). Harrison's Principles of Internal Medicine, 18th  Edition. New York, NY: McGraw-Hill.

  17. Miller, A. and Loscalzo, J. (2015). Drug-Coated Balloon versus Standard Percutaneous Transluminal Angioplasty: The IN.PACT SFA Trial. In: Longo, D. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., Jameson, J. L. and Loscalzo, J. (Eds). Harrison's Principles of Internal Medicine, 18th Edition. New York, NY:  McGraw-Hill.

  18. Steinhorn, B. S., Loscalzo, J. and Michel, T. (2015). Nitroglycerin and Nitric Oxide--A Rondo of Themes in Cardiovascular Therapeutics. N Engl J Med 373(3): 277-280.

  19. Geller, B. J., Stone, R. M., Merola, J. F., Levy, B. D. and Loscalzo, J. (2015). CLINICAL PROBLEM-SOLVING. A Man with Fever, Cough, and Rash. N Engl J Med 373(1): 74-80.

  20. Oldham, W. M., Clish, C. B., Yang, Y. and Loscalzo, J. (2015). Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress. Cell Metab 22(2): 291-303.

  21. Zhao, Y., Hu, Q., Cheng, F., Su, N., Wang, A., Zou, Y., Hu, H., Chen, X., Zhou, H. M., Huang, X., Yang, K., Zhu, Q., Wang, X., Yi, J., Zhu, L., Qian, X., Chen, L., Tang, Y., Loscalzo, J. and Yang, Y. (2015). SoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents. Cell Metab 21(5): 777-789.

  22. Waxman, A. and Loscalzo, J. (2015). Chapter 304: Pulmonary hypertension. In: Longo, D. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., Jameson, J. L. and Loscalzo, J. (Eds). Harrison's Principles of Internal Medicine, 19th Edition. New York, NY:  McGraw-Hill, pp. 1655-1660.

  23. Creager, M.A. and Loscalzo, J. (2015). Chapter 303: Chronic venous disease and lymphedema. In: Longo, D. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., Jameson, J. L. and Loscalzo, J. (Eds). Harrison's Principles of Internal Medicine, 19th Edition. New York, NY:  McGraw-Hill, pp. 1650-1655.

  24. Creager, M.A. and Loscalzo, J.  (2015). Chapter 302: Arterial diseases of the extremities. In: Longo, D. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., Jameson, J. L. and Loscalzo, J. (Eds). Harrison's Principles of Internal Medicine, 19th Edition. New York, NY:  McGraw-Hill, pp. 1643-1650.  

  25. Creager, M.A. and Loscalzo, J.  (2015). Chapter 301: Diseases of the aorta. In: Longo, D. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., Jameson, J. L. and Loscalzo, J. (Eds). Harrison's Principles of Internal Medicine, 19th Edition. New York, NY:  McGraw-Hill, pp. 1637-1643.

  26. Antman, E. and Loscalzo, J. (2015). Chapter 295: ST-Segment elevation myocardial infarction. In: Longo, D. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., Jameson, J. L. and Loscalzo, J. (Eds). Harrison's Principles of Internal Medicine, 19th Edition. New York, NY:  McGraw-Hill, pp. 1599-1611. 

  27. Antman, E. and Loscalzo, J. (2015). Chapter 293: Ischemic heart disease. In: Longo, D. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., Jameson, J. L. and Loscalzo, J. (Eds). Harrison's Principles of Internal Medicine, 19th Edition. New York, NY:  McGraw-Hill, pp. 1578-1593. 

  28. Lakdawala, N., Stevenson, L. W. and Loscalzo, J. (2015). Chapter 287: Cardiomyopathy and myocarditis. In: Longo, D. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., Jameson, J. L. and Loscalzo, J. (Eds). Harrison's Principles of Internal Medicine, 19th Edition. New York, NY:  McGraw-Hill, pp. 1553-1571.

  29. O’Gara, P. T. and Loscalzo, J. (2015). Chapter 286: Multiple and mixed valve disease. In: Longo, D. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., Jameson, J. L. and Loscalzo, J. (Eds). Harrison's Principles of Internal Medicine, 19th Edition. New York, NY:  McGraw-Hill, pp. 1550-1553.

  30. O’Gara, P. T. and Loscalzo, J. (2015). Chapter 285: Tricuspic and pulmonic valve disease. In: Longo, D. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., Jameson, J. L. and Loscalzo, J. (Eds). Harrison's Principles of Internal Medicine, 19th Edition. New York, NY:  McGraw-Hill, pp. 1547-1550.

  31. O’Gara, P. T. and Loscalzo, J. (2015). Chapter 284: Mitral valve disease. In: Longo, D. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., Jameson, J. L. and Loscalzo, J. (Eds). Harrison's Principles of Internal Medicine, 19th Edition. New York, NY:  McGraw-Hill, pp. 1539-1547.

  32. O’Gara, P. T. and Loscalzo, J. (2015). Chapter 283: Aortic valve disease. In: Longo, D. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., Jameson, J. L. and Loscalzo, J. (Eds). Harrison's Principles of Internal Medicine, 19th Edition. New York, NY:  McGraw-Hill, pp. 1528-1539.

  33. O’Gara, P. T. and Loscalzo, J. (2015). Chapter 267: Physical examination of the cardiovascular system. In: Longo, D. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., Jameson, J. L. and Loscalzo, J. (Eds). Harrison's Principles of Internal Medicine, 19th Edition. New York, NY:  McGraw-Hill, pp. 1821-1830.

  34. Loscalzo, J., Libby, P. and Epstein, J. (2015). Chapter 265e: Basic biology of the cardiovascular system. In: Longo, D. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., Jameson, J. L. and Loscalzo, J. (Eds). Harrison's Principles of Internal Medicine, 19th Edition. New York, NY:  McGraw-Hill, pp. 1441, e-chapter. 

  35. Loscalzo, J. (2015). Chapter 264: Approach to the patient with possible cardiovascular disease. In: Longo, D. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., Jameson, J. L. and Loscalzo, J. (Eds). Harrison's Principles of Internal Medicine, 19th Edition. New York, NY:  McGraw-Hill, pp. 1439-1441.

  36. Freedman, J. E. and Loscalzo, J. (2015). Chapter 142: Arterial and venous thrombosis. In: Longo, D. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., Jameson, J. L. and Loscalzo, J. (Eds). Harrison's Principles of Internal Medicine, 19th Edition. New York, NY:  McGraw-Hill, pp. 740-745.

  37. Loscalzo, J. (2015). Chapter 87e: Network medicine: systems biology in health and disease. In: Longo, D. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., Jameson, J. L. and Loscalzo, J. (Eds). Harrison's Principles of Internal Medicine, 19th Edition. New York, NY:  McGraw-Hill, pp. 451, e-chapter. 

  38. Loscalzo, J. (2015):  Chapter 52: Palpitations. In: Longo, D. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., Jameson, J. L. and Loscalzo, J. (Eds). Harrison's Principles of Internal Medicine, 19th Edition. New York, NY:  McGraw-Hill, pp. 254.

  39. O’Gara, P. T. and Loscalzo, J. (2015). Chapter 51e: Approach to the patient with a heart murmur. In: Longo, D. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., Jameson, J. L. and Loscalzo, J. (Eds). Harrison's Principles of Internal Medicine, 19th Edition. New York, NY:  McGraw-Hill, pp. 253, e-chapter. 

  40. Braunwald, E. and Loscalzo, J. (2015). Chapter 50: Edema. In: Longo, D. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., Jameson, J. L. and Loscalzo, J. (Eds). Harrison's Principles of Internal Medicine, 19th Edition. New York, NY:  McGraw-Hill, pp. 250-253.

  41. Loscalzo, J. (2015). Chapter 49: Hypoxia and cyanosis. In: Longo, D. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., Jameson, J. L. and Loscalzo, J. (Eds). Harrison's Principles of Internal Medicine, 19th Edition. New York, NY:  McGraw-Hill, pp. 247-250.

  42. Wang, R. S., Maron, B. A. and Loscalzo, J. (2015). Systems medicine: evolution of systems biology from bench to bedside. Wiley Interdiscip Rev Syst Biol Med 7(4): 141-161.

  43. Hall, K. T., Loscalzo, J. and Kaptchuk, T. J. (2015). Genetics and the placebo effect: the placebome. Trends Mol Med 21(5): 285-294.

  44. Fox, C. S., Hall, J. L., Arnett, D. K., Ashley, E. A., Delles, C., Engler, M. B., Freeman, M. W., Johnson, J. A., Lanfear, D. E., Liggett, S. B., Lusis, A. J., Loscalzo, J., MacRae, C. A., Musunuru, K., Newby, L. K., O'Donnell, C. J., Rich, S. S., Terzic, A., American Heart Association Council on Functional, G., Translational Biology, C. o. C., Stroke Nursing, C. o. C. C. C. o. Q. o. C., Outcomes, R., Council on, E. and Prevention (2015). Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association. Circulation 131(19): 1715-1736.

  45. Fox, C. S., Bonaca, M. A., Ryan, J. J., Massaro, J. M., Barry, K. and Loscalzo, J. (2015). Response to letters regarding article, "A randomized trial of social media from Circulation". Circulation 131(13): e396.

  46. Joseph, J. and Loscalzo, J. (2015). Nutri(meta)genetics and cardiovascular disease: novel concepts in the interaction of diet and genomic variation. Curr Atheroscler Rep 17(5): 505.

  47. Schaefer, L., Paik, J. M., Rennke, H., Levy, B. D. and Loscalzo, J. (2015). Clinical problem solving: Itching for a diagnosis. N Engl J Med 372(10): 964-968.

  48. Menche, J., Sharma, A., Kitsak, M., Ghiassian, S. D., Vidal, M., Loscalzo, J. and Barabasi, A. L. (2015). Disease networks. Uncovering disease-disease relationships through the incomplete interactome. Science 347(6224): 1257601.

  49. Loscalzo, J. (2015). Maintenance of certification: Good intentions gone awry. Trends Cardiovasc Med 25(4): 312-314.

  50. Keaney, J. F., Jr. and Loscalzo, J. (2015). Joseph A. Vita, MD, 1956-2014. Circulation 131(4): 432-433.

  51. Bader, A. R., Li, T., Wang, W., Kohane, D. S., Loscalzo, J. and Zhang, Y. Y. (2015). Preparation and characterization of SDF-1alpha-chitosan-dextran sulfate nanoparticles. J Vis Exp(95): 52323.

  52. Benjamin, I., Brown, N., Burke, G., Correa, A., Houser, S. R., Jones, D. W., Loscalzo, J., Vasan, R. S. and Whitman, G. R. (2015). American Heart Association Cardiovascular Genome-Phenome Study: foundational basis and program. Circulation 131(1): 100-112.

Protocols by Joseph Loscalzo
  1. Quantification of 2-Hydroxyglutarate Enantiomers by Liquid Chromatography-mass Spectrometry