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William M. Oldham


Ph.D. in Pharmacology, Department of Pharmacology, Vanderbilt University, 2006
M.D., Vanderbilt University School of Medicine, 2008

Current position

Instructor of Medicine, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
Associate Physician, Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA


  1. Oldham, W.M. and Loscalzo, J. (2016). Pharmacology of vascular tone. In: Golan, D.E., Armstrong, E.J. and Armstrong, A.W. (Eds). Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 4th Edition.  Philadelphia, PA:Wolters Kluwer/Lippincott, Williams, and Wilkins, pp.385-402. 

  2. Maron, B. A., Stephens, T. E., Farrell, L. A., Oldham, W. M., Loscalzo, J., Leopold, J. A. and Lewis, G. D. (2016). Elevated pulmonary arterial and systemic plasma aldosterone levels associate with impaired cardiac reserve capacity during exercise in left ventricular systolic heart failure patients: A pilot study. J Heart Lung Transplant 35(3): 342-351.

  3. Oldham, W. M., Lewis, G. D., Opotowsky, A. R., Waxman, A. B. and Systrom, D. M. (2016). Unexplained exertional dyspnea caused by low ventricular filling pressures: results from clinical invasive cardiopulmonary exercise testing. Pulm Circ 6(1): 55-62.

  4. Berry, N. C., Manyoo, A., Oldham, W. M., Stephens, T. E., Goldstein, R. H., Waxman, A. B., Tracy, J. A., Leary, P. J., Leopold, J. A., Kinlay, S., Opotowsky, A. R., Systrom, D. M. and Maron, B. A. (2015). Protocol for exercise hemodynamic assessment: performing an invasive cardiopulmonary exercise test in clinical practice. Pulm Circ 5(4): 610-618.

  5. Oldham, W. M., Clish, C. B., Yang, Y. and Loscalzo, J. (2015). Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress. Cell Metab 22(2): 291-303.

  6. Fessel, J. P. and Oldham, W. M. (2015). Pulmonary hypertension as a metabolic disease. In: Maron, B. A., Zamanian, R. and Waxman, A. B. (eds). Pulmonary Hypertension: Basic Science to Clinical Medicine. New York: Springer International Publishing. p. 135-146.

  7. Wang, R. S., Oldham, W. M. and Loscalzo, J. (2014). Network-based association of hypoxia-responsive genes with cardiovascular diseases. New J Phys 16(10): 105014.

  8. Maron, B. A., Oldham, W. M., Chan, S. Y., Vargas, S. O., Arons, E., Zhang, Y. Y., Loscalzo, J. and Leopold, J. A. (2014). Upregulation of steroidogenic acute regulatory protein by hypoxia stimulates aldosterone synthesis in pulmonary artery endothelial cells to promote pulmonary vascular fibrosis. Circulation 130(2): 168-179.

  9. Ciampa, E. J., Hunt, A. A., Arneson, K. O., Mordes, D. A., Oldham, W. M., Vin Woo, K., Owens, D. A., Cannon, M. D. and Dermody, T. S. (2011). A workshop on leadership for MD/PhD students. Med Educ Online 16.

  10. Oldham, W. M. and Systrom, D. M. (2010). Cardiopulmonary exercise testing in the evaluation of unexplained dyspnea. Advances in Pulmonary Hypertension 9: 101-106.

  11. Jernigan, K. K., Cselenyi, C. S., Thorne, C. A., Hanson, A. J., Tahinci, E., Hajicek, N., Oldham, W. M., Lee, L. A., Hamm, H. E., Hepler, J. R., Kozasa, T., Linder, M. E. and Lee, E. (2010). Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity. Sci Signal 3(121): ra37.

  12. Preininger, A. M., Funk, M. A., Oldham, W. M., Meier, S. M., Johnston, C. A., Adhikary, S., Kimple, A. J., Siderovski, D. P., Hamm, H. E. and Iverson, T. M. (2009). Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits. Biochemistry 48(12): 2630-2642.

  13. Oldham, W. M. and Hamm, H. E. (2008). Heterotrimeric G protein activation by G-protein-coupled receptors. Nat Rev Mol Cell Biol 9(1): 60-71.

  14. Preininger, A. M., Oldham, W. M. and Hamm, H. E. (2007). Biophysical approaches to the study of G-protein structure and function. In: Fliesler, S. J. and Kisselev, O. (eds). Signal Transduction in the Retina. New York: CRC Press; 2007. p. 3-32.

  15. Oldham, W. M. and Hamm, H. E. (2007). How do receptors activate G proteins? Adv Protein Chem 74: 67-93.

  16. Oldham, W. M., Van Eps, N., Preininger, A. M., Hubbell, W. L. and Hamm, H. E. (2007). Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins. Proc Natl Acad Sci U S A 104(19): 7927-7932.

  17. Holinstat, M., Oldham, W. M. and Hamm, H. E. (2006). G-protein-coupled receptors: evolving views on physiological signalling: symposium on G-protein-coupled receptors: evolving concepts and new techniques. EMBO Rep 7(9): 866-869.

  18. Oldham, W. M. and Hamm, H. E. (2006). Structural basis of function in heterotrimeric G proteins. Q Rev Biophys 39(2): 117-166.

  19. Van Eps, N., Oldham, W. M., Hamm, H. E. and Hubbell, W. L. (2006). Structural and dynamical changes in an alpha-subunit of a heterotrimeric G protein along the activation pathway. Proc Natl Acad Sci U S A 103(44): 16194-16199.

  20. Oldham, W. M., Van Eps, N., Preininger, A. M., Hubbell, W. L. and Hamm, H. E. (2006). Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. Nat Struct Mol Biol 13(9): 772-777.

  21. Preininger, A. M., Henage, L. G., Oldham, W. M., Yoon, E. J., Hamm, H. E. and Brown, H. A. (2006). Direct modulation of phospholipase D activity by Gbetagamma. Mol Pharmacol 70(1): 311-318.

  22. Kwong, J., Roundabush, F. L., Hutton Moore, P., Montague, M., Oldham, W., Li, Y., Chin, L. S. and Li, L. (2000). Hrs interacts with SNAP-25 and regulates Ca(2+)-dependent exocytosis. J Cell Sci 113 ( Pt 12): 2273-2284.

Protocols by William M. Oldham
  1. Quantification of 2-Hydroxyglutarate Enantiomers by Liquid Chromatography-mass Spectrometry